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Autism spectrum disorder (ASD) is a neurodevelopmental disorder that manifests during the early developmental period of childhood. Behaviourally characterized by impairments in social interaction and communication, in combination with stereotyped and restricted patterns of behaviour and/or interest, it is currently believed that ASD occurs in approximately 1–2% of individuals. ASD is more prevalent among males than females (4–5:1), but the mechanisms resulting in this discrepancy are still unclear. This chapter will serve as an introduction to ASD, covering the topics of disorder history, prevalence rates, demographics, diagnostic criteria, differential diagnosis, and discussions on current and future diagnostic classification systems. The remaining chapters within Section 4 will then provide detailed discussions on more specific topics related to ASD, including current understandings of treatment planning, prevention and epidemiology, genetics, imaging, and disorder management.
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Individuals with autism spectrum disorder (ASD) often have co-morbid anxiety and depression. Alexithymia and emotion regulation difficulties are commonly seen in individuals with ASD and in mood disorders. We hypothesized that alexithymia and emotional regulation would mediate the relationship between autistic features and anxiety/depression symptom severity. We collected data about emotional regulation, alexithymia, autistic symptoms and depression/anxiety in a sample of 64 young adults with ASD. We constructed two serial multiple mediator models, using autistic features as the independent variable and anxiety/depression symptoms as outcome variables. The serial relationship between alexithymia and emotional regulation mediated associations between autistic features and depression and anxiety, separately. The findings suggest that targeting alexithymia may benefit therapies designed to alleviate mood disorders in ASD.
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There has been a heightened awareness of an increased risk of suicidality among individuals with autism spectrum disorder (ASD) due to high rates of suicidal ideation (SI) in this population (11–66%). The current study investigated the rate of parent-endorsed SI and associated clinical features in 48 youths with ASD (Age; M: 12.97 years, SD: 2.33). SI was endorsed in 18.75% of participants. Youth with SI exhibited significantly higher levels of affective problems, externalizing problems, feelings of humiliation and rejection, and symptoms related to perfectionism. Results indicate that co-occurring mental health problems are associated with suicidal ideation and provide relevant targets for psychotherapeutic intervention. This preliminary study in a modest sample suggests the value of further research in larger samples to replicate and generalize these findings.
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The syndrome of infantile autism was identified in 1943 (although cases clearly were present earlier). Very quickly there began to be a debate about the nature of autism and the boundaries of the autism phenotype. In the 1970s multiple lines of evidence emerged to suggest that autism should be recognized as a disorder in its own right and this happened in 1980. Since that time there has been an explosion of research and the debate about the boundaries of the diagnostic concept has continued. It does appear that individuals on the autism spectrum present special issues and challenges in terms of their interactions with the legal system at all levels. In this chapter we summarize the state of scientific knowledge and highlight some important areas relevant to those who deal with individuals with autism in legal settings.
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Autism spectrum disorder (ASD) affects approximately 1 in 59 children, but there are currently no biomedical treatments available that target the core symptoms (1). Preliminary evidence suggests that repetitive transcranial magnetic stimulation (rTMS) may have the potential to alleviate difficulties experienced by individuals with ASD (2). The evidence supporting the use of rTMS for ASD has led researchers in the field to form a consensus group that has met annually since 2014. Here we summarize discussions from the most recent meeting in May 2017, including recommendations for future research directions.
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