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With the continuously increasing number of new confirmed COVID-19 cases, many health experts worried about the possibility of a ‘second wave’ outbreak, which might cause more deaths and hit economies even worse. This article looks at the experiences of fighting COVID-19 from three Asia-Pacific countries and discusses whether it is a wise decision to open up America again at this time.

This paper will discuss the correlation between the SAT and the Math Inventory Test. Many school districts adopted the Math Inventory as a tool to measure student growth from grades kindergarten through high school. The Math Inventory is a computer-administered test that gives students math problems spanning from counting to high school level math. When completed, the students are given a quantile measure, much like a Lexile score for reading skill. The purpose of this study is to figure out if success on the Math Inventory is a good indicator for performing well on the SAT. For most high schools around the United States, objectives and lessons are aligned with those of the SAT. The goal of high school teachers is for students to excel on the SAT so that they can go to college, which means the tests used in middle school should be aligned with that goal. If the Math Inventory is not, then it might not be a very good use of school time and resources. Data was analyzed from the 2017-2018 school year from ten different high schools in an urban school district to determine the correlation between Math Inventory score, and the math score/sub scores of SAT/PSAT. The value of the Pearson’s correlation coefficient is used to suggest a fairly moderate positive relationship between these two variables. © 2021, International Journal of Information and Education Technology. All rights reserved.

The primary goals of this study are to determine if the datasets of positive COVID-19 test cases and CO2 emissions from Connecticut over the span of March 24th, 2020-October 31, 2021 are in any ways correlated. With climate change a prominent issue facing the entire world today, it is important to explore methods of providing records of past patterns of greenhouse gas emissions in order to inform decision making that could reduce future ones. Autoregressive integrated moving average (ARIMA) modeling is also implemented in this paper to provide forecasting based on CO2 emissions in CT starting from 2019. The most significant results from this paper are as follows: the CO2 emission data of transportation sectors including ground transportation, domestics aviation, and international aviation and weekly COVID-19 positive test cases data has a strong relationship during the first 28 weeks of the pandemic with a correlation of -86.34%. The CO2 emissions experienced on average a -22.96% change of pre-pandemic vs during initial quarantine conditions and at most a - 44.48% change when comparing the pre-pandemic mean to the during initial quarantine minimum value. Lastly, the ARIMA model found to have the lowest Akaike information criterion (AIC) was ARIMA (4,0,4). In conclusion, in the event of a collective global pandemic and lockdown conditions, less traveling resulting in a correlated decrease of CO2 emissions. This means that perhaps concentrated efforts on reducing unnecessary travel could help mitigate the levels of carbon dioxide emissions as a more long-term solution to climate change opposed to the pandemic’s short-term example.

Agriculture ranks as one of the top contributors to global warming and nutrient pollution. Quantifying life cycle environmental impacts from agricultural production serves as a scientific foundation for forming effective remediation strategies. However, methods capable of accurately and efficiently calculating spatially explicit life cycle global warming (GW) and eutrophication (EU) impacts at the county scale over a geographic region are lacking. The objective of this study was to determine the most efficient and accurate model for estimating spatially explicit life cycle GW and EU impacts at the county scale, with corn production in the U.S.’s Midwest region as a case study. This study compared the predictive accuracies and efficiencies of five distinct supervised machine learning (ML) algorithms, testing various sample sizes and feature selections. The results indicated that the gradient boosting regression tree model built with approximately 4000 records of monthly weather features yielded the highest predictive accuracy with cross-validation (CV) values of 0.8 for the life cycle GW impacts. The gradient boosting regression tree model built with nearly 6000 records of monthly weather features showed the highest predictive accuracy with CV values of 0.87 for the life cycle EU impacts based on all modeling scenarios. Moreover, predictive accuracy was improved at the cost of simulation time. The gradient boosting regression tree model required the longest training time. ML algorithms demonstrated to be one million times faster than the traditional process-based model with high predictive accuracy. This indicates that ML can serve as an alternative surrogate of process-based models to estimate life-cycle environmental impacts, capturing large geographic areas and timeframes.

Life Cycle Assessment (LCA) is a foundational method for quantitative assessment of sustainability. Increasing data availability and rapid development of machine learning (ML) approaches offer new opportunities to advance LCA. Here, we review current progress and knowledge gaps in applying ML techniques to support LCA, and identify future research directions for LCAs to better harness the power of ML. This review analyzes forty studies reporting quantitative assessment with a combination of LCA and ML methods. We found that ML approaches have been used for generating life cycle inventories, computing characterization factors, estimating life cycle impacts, and supporting life cycle interpretation. Most of the reviewed studies employed a single ML method, with artificial neural networks (ANNs) as the most frequently applied approach. Both supervised and unsupervised ML techniques were used in LCA studies. For studies using supervised ML, training datasets were derived from diverse sources, such as literature, lab experiments, existing databases, and model simulations. Over 70 % of these reviewed studies trained ML models with less than 1500 sample datasets. Although these reviewed studies showed that ML approaches help improve prediction accuracy, pattern discovery and computational efficiency, multiple areas deserve further research. First, continuous data collection and compilation is needed to support more reliable ML and LCA modeling. Second, future studies should report sufficient details regarding the selection criteria for ML models and present model uncertainty analysis. Third, incorporating deep learning models into LCA holds promise to further improve life cycle inventory and impact assessment. Finally, the complexity of current environmental challenges calls for interdisciplinary collaborative research to achieve deep integration of ML into LCA to support sustainable development.

Human mesenchymal stem cells (hMSCs) are multipotent progenitor cells with the potential to differentiate into various cell types, including osteoblasts, chondrocytes, and adipocytes. These cells have been extensively employed in the field of cell-based therapies and regenerative medicine due to their inherent attributes of self-renewal and multipotency. Traditional approaches for assessing hMSCs differentiation capacity have relied heavily on labor-intensive techniques, such as RT-PCR, immunostaining, and Western blot, to identify specific biomarkers. However, these methods are not only time-consuming and economically demanding, but also require the fixation of cells, resulting in the loss of temporal data. Consequently, there is an emerging need for a more efficient and precise approach to predict hMSCs differentiation in live cells, particularly for osteogenic and adipogenic differentiation. In response to this need, we developed innovative approaches that combine live-cell imaging with cutting-edge deep learning techniques, specifically employing a convolutional neural network (CNN) to meticulously classify osteogenic and adipogenic differentiation. Specifically, four notable pre-trained CNN models, VGG 19, Inception V3, ResNet 18, and ResNet 50, were developed and tested for identifying adipogenic and osteogenic differentiated cells based on cell morphology changes. We rigorously evaluated the performance of these four models concerning binary and multi-class classification of differentiated cells at various time intervals, focusing on pivotal metrics such as accuracy, the area under the receiver operating characteristic curve (AUC), sensitivity, precision, and F1-score. Among these four different models, ResNet 50 has proven to be the most effective choice with the highest accuracy (0.9572 for binary, 0.9474 for multi-class) and AUC (0.9958 for binary, 0.9836 for multi-class) in both multi-class and binary classification tasks. Although VGG 19 matched the accuracy of ResNet 50 in both tasks, ResNet 50 consistently outperformed it in terms of AUC, underscoring its superior effectiveness in identifying differentiated cells. Overall, our study demonstrated the capability to use a CNN approach to predict stem cell fate based on morphology changes, which will potentially provide insights for the application of cell-based therapy and advance our understanding of regenerative medicine.

Background: Attenuation correction (AC) using CT transmission scanning enables the accurate quantitative analysis of dedicated cardiac SPECT. However, AC is challenging for SPECT-only scanners. We developed a deep learning-based approach to generate synthetic AC images from SPECT images without AC. Methods: CT-free AC was implemented using our customized Dual Squeeze-and-Excitation Residual Dense Network (DuRDN). 172 anonymized clinical hybrid SPECT/CT stress/rest myocardial perfusion studies were used in training, validation, and testing. Additional body mass index (BMI), gender, and scatter-window information were encoded as channel-wise input to further improve the network performance. Results: Quantitative and qualitative analysis based on image voxels and 17-segment polar map showed the potential of our approach to generate consistent SPECT AC images. Our customized DuRDN showed superior performance to conventional network design such as U-Net. The averaged voxel-wise normalized mean square error (NMSE) between the predicted AC images by DuRDN and the ground-truth AC images was 2.01 ± 1.01%, as compared to 2.23 ± 1.20% by U-Net. Conclusions: Our customized DuRDN facilitates dedicated cardiac SPECT AC without CT scanning. DuRDN can efficiently incorporate additional patient information and may achieve better performance compared to conventional U-Net. © 2021, American Society of Nuclear Cardiology.

Whole-body dynamic fluoro-D-glucose (FDG)-positron emission tomography (PET) imaging through continuous-bed-motion (CBM) mode multi-pass acquisition protocol is a promising metabolism measurement. However, inter-pass misalignment originating from body movement could degrade parametric quantification. We aim to apply a non-rigid registration method for inter-pass motion correction in whole-body dynamic PET. 27 subjects underwent a 90-min whole-body FDG CBM PET scan on a Biograph mCT (Siemens Healthineers), acquiring 9 over-the-heart single-bed passes and subsequently 19 CBM passes (frames). The inter-pass motion correction was executed using non-rigid image registration with multi-resolution, B-spline free-form deformations. The parametric images were then generated by Patlak analysis. The overlaid Patlak slope K_i and y-intercept V_b images were visualized to qualitatively evaluate motion impact and correction effect. The normalized weighted mean-squared Patlak fitting errors (NFEs) were compared in the whole body, head, and hypermetabolic regions of interest (ROIs). In K_i images, ROI statistics were collected and malignancy discrimination capacity was estimated by the area under the receiver operating characteristic curve (AUC). After the inter-pass motion correction was applied, the spatial misalignment appearance between K_i and V_b images was successfully reduced. Voxel-wise normalized fitting error maps showed global error reduction after motion correction. The NFE in the whole body ( p \,\,= 0.0013), head ( p \,\,= 0.0021), and ROIs ( p \,\,= 0.0377) significantly decreased. The visual performance of each hypermetabolic ROI in K_i images was enhanced, while 3.59% and 3.67% average absolute percentage changes were observed in mean and maximum K_i values, respectively, across all evaluated ROIs. The estimated mean K_i values had substantial changes with motion correction ( p \,\,= 0.0021). The AUC of both mean K_i and maximum K_i after motion correction increased, possibly suggesting the potential of enhancing oncological discrimination capacity through inter-pass motion correction.