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  • We assessed the beliefs of 49 college students regarding the acquired immunodeficiency syndrome (AIDS), condom use, and sexual behaviors related to AIDS prevention. Roy's modes of self-concept, interdependence, and role function were used as a framework to find psychosocial determinants that influence safer sex practices. Interdependence was measured by a sexual regard scale. Beliefs regarding both AIDS beliefs and condom were very positive. Students were selectively using safer sex practices; most reported avoiding high-risk partners, but only 39% were using condoms. No significant associations were found among the four independent measures of AIDS beliefs, condom beliefs, self-esteem, and sexual regard or with the dependent measure, AIDS safer sex practices. A two-hour safer sex educational module did change several beliefs but did not increase safer sex practices. Most participating students stated they had a good understanding of how AIDS was spread, they knew how to use condoms correctly, and they discussed AIDS with friends and parents.

  • Background. The objective of this study was to identify factors that categorize patients with epithelial ovarian carcinoma into favorable and unfavorable prognostic groups at the time of initial treatment. Methods. Data were analyzed from 51 women who were treated at Yale University, had an evaluable CA 125 half-life (t 0.5), and were followed for disease recurrence for at least 2 years. Results. Grade, maximum level of CA 125, and histology did not provide useful prognostic information. Stage, residual disease, minimum CA 125, and CA 125 t 0.5 individually were predictive of persistent disease or recurrence within 3 years of diagnosis with sensitivities of 97, 70, 34, and 49%, respectively, and specificities of 33, 83, 100, and 83%, respectively. When these factors are combined, defining an unfavorable prognostic group as those patients having residual disease greater than 1 cm, CA 125 t 0.5 greater than 12 days, or minimum CA 125 never falling below 35 U/ml, sensitivity and specificity were 96 and 65%, respectively, at 1 year of follow-up and 91 and 75%, respectively, at 3 years of follow-up. Conclusions. In those patients in whom residual small volume disease after primary surgery indicates a good prognosis, minimum CA 125 and CA 125 t 0.5 during chemotherapy can further categorize patients into favorable and unfavorable prognostic groups.

  • Objectives: This study examined the clinical significance of non-complexed (free) prostate-specific antigen (PSA) in the differential diagnosis of prostate cancer with an emphasis on patients with total PSA values between 4.0 and 10.0 ng/mL (the diagnostic gray zone). Methods: Serum samples were obtained from three specimen banks. Patient samples consisted of 55 untreated historically confirmed primary cancer, 62 men with untreated benign prostatic disease histologically confirmed by 6 negative sextant biopsies, and 64 asymptomatic healthy male controls with normal digital rectal examinations and PSA values less than 4.0 ng/mL. All patients were between the ages of 50 and 75 years. Total PSA levels were determined using the PA immunoassay performed on the TOSOH AIA-1200 automated immunoassay instrument. Free PSA levels were determined using a monoclonal-polyclonal antibody sandwich radioimmunoassay. The proportion of free to total PSA was calculated by dividing the patient's free PSA value by the total PSA value. Results: When all subjects were included, both total PSA and the proportion of free to total PSA significantly differentiated between patients with prostate cancer and patients with benign histologic conditions (P< 0.0001). However, in men with total PSA values between 4.0 and 10.0 ng/mL, the proportion of free to total PSA significantly differentiated between patients with benign and malignant histologic conditions (P = 0.0004), whereas the total PSA did not (P = 0.13). Among this subgroup of patients, the analysis of sensitivity and specificity showed that the proportion of free to total PSA had a clearly higher specificity compared with that of the total PSA at the same level of sensitivity. Conclusions: Measurement of the free PSA level in a patient's serum and calculation of the proportion of free to total PSA enhances the ability to distinguish benign histologic conditions from cancer while retaining high sensitivity for detecting cancer in men who present with total PSA levels between 4.0 and 10.0 ng/mL. A large-scale population-based study is currently in progress to confirm this preliminary finding. © 1995.

Last update from database: 3/13/26, 4:15 PM (UTC)

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