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Resonance Raman spectroscopy is used for rapid detection of skin BCC cancer. The cross-validated classification accuracy is achieved to be as high as 98% using nonnegative matrix factorization along with support vector machine statistical method. © OSA 2017.
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Currently, liquid biopsy method is mainly used for tumor detection based on genomic molecular alterations in vitro. Liquid biopsy is superior to traditional tissue biopsy techniques and its diagnosis time of disease and repeated diagnosis of liquid biopsy are new breakthroughs in clinical application. Liquid biopsy method can be used to detect most human disease based on genetic biomarkers from body fluids, among which, special biomarkers in blood and cerebrospinal fluid (CSF) samples are the main research objects, and have made good achievements in preliminary clinical applications. The application of optical spectroscopy in the field of liquid biopsy has aroused great interest among researchers and demonstrated the potential of its clinical application for oncology. The aim of this study is to reveal the optical spectroscopic characteristics of the main biochemical components of CSF of brain tumor using visible resonance Raman (VRR) spectroscopy ex vivo. Tumor-associated proteins, glucose, lactate and other metabolites released to CSF can be used as markers for liquid biopsy. We studied the VRR spectra of CSF samples from 7 types of brain tumor patients. The characteristic VRR modes that were found and may be used as a combination of multiple analyte biomarkers include amyloid-β and tau protein, excess neurotransmitters such as glutamic acid derived from the exchange with interstitial fluid (ISF), DNA, glucose, lactate, etc. for optical liquid biopsy analyses. Another interesting finding was that CSF of different types of tumors showed different images similar to the crystallization of water under the optical microscope. Considering our previous study, the current study on CSF provides another proof that the VRR system can provide a complete scan region of 200 - 4000cm-1 as a clinical tool for non-invasive diagnosis of brain disease. © 2024 SPIE.
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Despite their close proximity, the complex interplay between the two Magellanic Clouds, the Milky Way and the resulting tidal features, is still poorly understood. Recent studies have shown that the Large Magellanic Cloud (LMC) has a very extended disc strikingly perturbed in its outskirts.We search for recent star formation in the far outskirts of the LMC, out to ~30° from its centre.We have collected intermediate-resolution spectra of 31 young star candidates in the periphery of the LMC and measured their radial velocity, stellar parameters, distance and age. Our measurements confirm membership to the LMC of six targets, for which the radial velocity and distance values match well with those of the Cloud. These objects are all young (10-50 Myr), main-sequence stars, projected between 7° and 13° from the centre of the parent galaxy. We compare the velocities of our stars with those of a disc model, and find that our stars have low to moderate velocity differences with the disc model predictions, indicating that they were formed in situ. Our study demonstrates that recent star formation occurred in the far periphery of the LMC, where thus far only old objects were known. The spatial configuration of these newly formed stars appears ring-like with a radius of 12 kpc and a displacement of 2.6 kpc from the LMC's centre. This structure, if real, would be suggestive of a star formation episode triggered by an off-centre collision between the Small Magellanic Cloud and the LMC's disc. © 2016 The Authors.
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