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Di-2-ethylhexyl phthalate (DEHP) exposure is widespread in the general population and previous research has suggested that it contains endocrine-disrupting properties that can adversely affect the reproductive health system. The objective of this study was to use the 2013–2016 National Health and Nutrition Examination Survey (NHANES) data to assess the potential association between DEHP exposure and infertility in women. Using a nationally representative, cross-sectional study design, we used multiple logistic regression to measure the association of urinary metabolites of DEHP with self-reported history of infertility among women. Four metabolites of DEHP were examined: mono(2-ethylhexyl)phthalate (MEHP), mono(2-ethyl-5-hydroxy-hexyl)phthalate (MEHHP), mono(2-ethyl-5-oxy-hexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxy-pentyl)phthalate (MECPP). These metabolites were calculated into a molar sum of DEHP (∑DEHP) and split into quartiles for analysis. After adjusting for age and race, ∑DEHP was associated with increased odds of infertility for the second quartile (AOR = 2.35, 95% CI [1.24,4.44], p = 0.01) and third quartile (AOR = 2.83, 95% CI [1.57, 5.10], p ¡ 0.01) when compared to the first quartile (reference). The adjusted OR for the highest quartile of ∑DEHP found no association and it was not statistically significant (AOR = 0.99, 95 %CI [0.57, 1.73], p = 0.98). The findings of this study add to the already complex existing literature on phthalate exposure and infertility. These findings warrant further population-based cohort studies on phthalate exposure and their relationship to infertility in humans. © 2021 Elsevier Inc.
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Objective: Even healthy college students are vulnerable to severe complications associated with seasonal influenza (flu). Despite national directives to increase influenza vaccination compliance, college campuses remain woefully below national goals. This study aimed to identify factors correlated with the decision to voluntarily receive an influenza vaccine. Additionally, students’ reasons for non-vaccination were also examined. Participants: 1021 undergraduate students across four professional schools. Methods: A representative cross-sectional survey was conducted at a public, urban university. Results: The survey measured self-reported influenza vaccination: an overall influenza vaccination rate of 38% was identified. Student characteristics associated with increased influenza vaccination included students’ enrollment in academic health disciplines; being female; human papillomavirus (HPV) vaccination; and no marijuana use in the last month. Barriers to influenza vaccination included contraindications, mistrust issues, and personal reasons. Conclusion: Universities that can identify facilitators and barriers to voluntary influenza vaccination can assist with program initiatives to improve influenza vaccination compliance rates. © 2021 Taylor & Francis Group, LLC.