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  • Grace, L. (2017). Using time dynamically in static intervals: Does it close the achievement gap? Learning Environments Research, 20(2), 249–267. https://doi.org/10.1007/s10984-017-9227-z

    A mixed-methods study was undertaken with 118 biology students in two urban high schools. A Student-Centered Adaptable Learning Environment (SCALE) was created to improve engagement from affective and cognitive perspectives using choice, creativity and technological allowances. Results demonstrated that fast and slow learners are generally separated by about 30 min in terms of inputting speeds, but can be as much as 65 min apart from one another. Given that traditional classrooms afford students only 45 min in which to learn, static time could have become a source of inequity in public schools. SCALE optimally allowed for the dynamic use of time in constrained periods, therefore reducing and even eliminating any negative relationships between speed of learning and resultant achievement gains in the block setting. Especially benefitting from their ability to maneuver were the slowest learners, who showed the largest achievement improvements in either time interval amongst ability groupings. As learning speed can be the most critical contributing component of resultant educational outcomes, providing students the ability to use time dynamically should be considered as a feasible solution to helping teachers reestablish equity in mixed-ability classrooms in public schools. © 2017, Springer Science+Business Media Dordrecht.

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  • Liu, X., Gao, X., Zheng, S., Wang, B., Li, Y., Zhao, C., Muftuoglu, Y., Chen, S., Li, Y., Yao, H., Sun, H., Mao, Q., You, C., Guo, G., & Wei, Y. (2017). Modified nanoparticle mediated IL-12 immunogene therapy for colon cancer. Nanomedicine : Nanotechnology, Biology, and Medicine, 13(6), 1993–2004. https://doi.org/10/gjtkwr

    For the past few years, immunotherapy has recently shown considerable clinical benefit in CRC therapy, and the application of immunologic therapies in cancer treatments continues to increase perennially. Interleukin-12, an ideal candidate for tumor immunotherapy, could activate both innate and adaptive immunities. In this study, we developed a novel gene delivery system with a self-assembly method by MPEG-PLA and DOTAP(DMP) with zeta-potential value of 38.5mV and size of 37.5nm. The supernatant of lymphocytes treated with supernatant from Ct26 transfected pIL12 with DMP could inhibit Ct26 cells growth ex vivo. Treatment of tumor-bearing mice with DMP-pIL12 complex has significantly inhibited tumor growth at both the subcutaneous and peritoneal model in vivo by inhibiting angiogenesis, promoting apoptosis and reducing proliferation. The IL-12 plasmid and DMP complex may be used to treat the colorectal cancer in clinical as a new drug. Copyright © 2017 Elsevier Inc. All rights reserved.

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Last update from database: 3/25/26, 6:13 PM (UTC)