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Intrinsic fluorescence spectra of fresh normal and cancerous human breast tissues were measured using two selective excitation wavelengths including 290nm and 340nm. Dual-wavelength excitation may reveal more molecular information than single-wavelength excitation. In the meantime, it is significantly faster than the acquisition of excitation-emission (EEM) matrix. Unsupervised machine learning algorithms principal component analysis (PCA) and non-negative matrix factorization (NMF) were used to reduce the dimensionality of the spectral data. The relative concentrations of the basis spectra retrieved by PCA and NMF were considered features of the samples and used to distinguish normal and malignant tissues. The performances of classification using support vector machine (SVM) based on PCA and NMF features were compared. The classification using spectral data with dual-wavelength excitation was compared with single-wavelength excitation. Classification based on NMF-retrieved components from spectral data with dual-wavelength excitation yielded the best performance. © 2019 SPIE.

We report a new measurement of D0-meson production at mid-rapidity (|y|<1) in Au + Au collisions at sNN=200GeV utilizing the heavy flavor tracker, a high resolution silicon detector at the STAR experiment. Invariant yields of D0 mesons with transverse momentum pT9GeV/c are reported in various centrality bins (0-10%, 10-20%, 20-40%, 40-60%, and 60-80%). Blast-wave thermal models are used to fit the D0-meson pT spectra to study D0 hadron kinetic freeze-out properties. The average radial flow velocity extracted from the fit is considerably smaller than that of light hadrons (π,K, and p), but comparable to that of hadrons containing multiple strange quarks (φ,Ξ-), indicating that D0 mesons kinetically decouple from the system earlier than light hadrons. The calculated D0 nuclear modification factors reaffirm that charm quarks suffer a large amount of energy loss in the medium, similar to those of light quarks for pT>4GeV/c in central 0-10% Au + Au collisions. At low pT, the nuclear modification factors show a characteristic structure qualitatively consistent with the expectation from model predictions that charm quarks gain sizable collective motion during the medium evolution. The improved measurements are expected to offer new constraints to model calculations and help gain further insights into the hot and dense medium created in these collisions. © 2019 American Physical Society.

We report the first measurement of the inclusive jet and the dijet longitudinal double-spin asymmetries, ALL, at midrapidity in polarized pp collisions at a center-of-mass energy s=510 GeV. The inclusive jet ALL measurement is sensitive to the gluon helicity distribution down to a gluon momentum fraction of x≈0.015, while the dijet measurements, separated into four jet-pair topologies, provide constraints on the x dependence of the gluon polarization. Both results are consistent with previous measurements made at s=200 GeV in the overlapping kinematic region, x>0.05, and show good agreement with predictions from recent next-to-leading order global analyses. © 2019 authors. Published by the American Physical Society.

J/ψ suppression has long been considered a sensitive signature of the formation of the Quark-Gluon Plasma (QGP) in relativistic heavy-ion collisions. In this letter, we present the first measurement of inclusive J/ψ production at mid-rapidity through the dimuon decay channel in Au+Au collisions at sNN=200 GeV with the STAR experiment. These measurements became possible after the installation of the Muon Telescope Detector was completed in 2014. The J/ψ yields are measured in a wide transverse momentum (pT) range of 0.15 GeV/c to 12 GeV/c from central to peripheral collisions. They extend the kinematic reach of previous measurements at RHIC with improved precision. In the 0-10% most central collisions, the J/ψ yield is suppressed by a factor of approximately 3 for pT&gt;5 GeV/c relative to that in p+p collisions scaled by the number of binary nucleon-nucleon collisions. The J/ψ nuclear modification factor displays little dependence on pT in all centrality bins. Model calculations can qualitatively describe the data, providing further evidence for the color-screening effect experienced by J/ψ mesons in the QGP. © 2019 The Author(s)

We report new STAR measurements of the single-spin asymmetries AL for W+ and W- bosons produced in polarized proton-proton collisions at s=510 GeV as a function of the decay-positron and decay-electron pseudorapidity. The data were obtained in 2013 and correspond to an integrated luminosity of 250 pb-1. The results are combined with previous results obtained with 86 pb-1. A comparison with theoretical expectations based on polarized lepton-nucleon deep-inelastic scattering and prior polarized proton-proton data suggests a difference between the ū and d quark helicity distributions for 0.05<x<0.25. In addition, we report new results for the double-spin asymmetries ALL for W±, as well as AL for Z/γ∗ production and subsequent decay into electron-positron pairs. © 2019 authors. Published by the American Physical Society.

We present measurements of the differential cross sections of inclusive J/ψ meson production as a function of transverse momentum (pTJ/ψ) using the μ+μ- and e+e- decay channels in proton+proton collisions at center-of-mass energies of 510 and 500 GeV, respectively, recorded by the STAR detector at the Relativistic Heavy Ion Collider. The measurement from the μ+μ- channel is for 0<pTJ/ψ<9 GeV/c and rapidity range |yJ/ψ|<0.4, and that from the e+e- channel is for 4<pTJ/ψ<20 GeV/c and |yJ/ψ|<1.0. The ψ(2S) to J/ψ ratio is also measured for 4<pTmeson<12 GeV/c through the e+e- decay channel. Model calculations, which incorporate different approaches toward the J/ψ production mechanism, are compared with experimental results and show reasonable agreement within uncertainties. © 2019 authors. Published by the American Physical Society.

We present the discovery from Transiting Exoplanet Survey Satellite (TESS) data of LTT 1445Ab. At a distance of 6.9 pc, it is the second nearest transiting exoplanet system found to date, and the closest one known for which the primary is an M dwarf. The host stellar system consists of three mid-to-late M dwarfs in a hierarchical configuration, which are blended in one TESS pixel. We use MEarth data and results from the Science Processing Operations Center data validation report to determine that the planet transits the primary star in the system. The planet has a radius of, an orbital period of days, and an equilibrium temperature of K. With radial velocities from the High Accuracy Radial Velocity Planet Searcher, we place a 3σ upper mass limit of 8.4 on the planet. LTT 1445Ab provides one of the best opportunities to date for the spectroscopic study of the atmosphere of a terrestrial world. We also present a detailed characterization of the host stellar system. We use high-resolution spectroscopy and imaging to rule out the presence of any other close stellar or brown dwarf companions. Nineteen years of photometric monitoring of A and BC indicate a moderate amount of variability, in agreement with that observed in the TESS light-curve data. We derive a preliminary astrometric orbit for the BC pair that reveals an edge-on and eccentric configuration. The presence of a transiting planet in this system hints that the entire system may be co-planar, implying that the system may have formed from the early fragmentation of an individual protostellar core. © 2019. The American Astronomical Society. All rights reserved..

Laser-induced fluorescence (LIF) technique was used to generate spectral signatures of endogenous fluorophores relevant to the tissue molecular composition changes in human brain glioma tumors. The goal is to study the changes of fluorescence emission spectra from endogenous fluorophores in human brain glioma of different grades, and to find new biomarkers for prognostic optical molecular pathological diagnosis. Two hundred and thirty-seven (237) native fluorescence spectra from 61 subjects were measured using LabRAM HR Evolution micro photoluminescence (PL) system for four grades of glioma tumors in ex-vivo. The differences of four grades of glioma tumors were identified by the characteristic fluorophores fingerprints under the excitation laser wavelength at UV 325nm. To our best knowledge, this is the first report for human brain study using this technique. The fluorescence peaks of biomarkers with major contribution were found, including tryptophan, collagen, elastin, reduced nicotinamide adenine dinucleotide (NADH), flavin adenine dinucleotide (FAD) and phospholipids that play important roles in the cellular energy metabolism and glycolysis pathway. The ratios of peak intensities and the peak positions in fluorescence spectra of may be used to diagnose human brain diseases or to guide biopsy during surgical resection. © 2019 SPIE.

A VRR-LRR analyzer with handheld fiber‐optic probe is reported for the first time for diagnosis of brain GBM in vivo. The sensitivity for identification is 80% compared with histopathology examination. © OSA 2019. The Author(s).

Global hyperon polarization, P¯H, in Au+Au collisions over a large range of collision energy, sNN, was recently measured and successfully reproduced by hydrodynamic and transport models with intense fluid vorticity of the quark-gluon plasma. While naïve extrapolation of data trends suggests a large P¯H as the collision energy is reduced, the behavior of P¯H at small sNN¡7.7 GeV is unknown. Operating the STAR experiment in fixed-target mode, we measured the polarization of Λ hyperons along the direction of global angular momentum in Au+Au collisions at sNN=3 GeV. The observation of substantial polarization of 4.91±0.81(stat.)±0.15(syst.)% in these collisions may require a reexamination of the viscosity of any fluid created in the collision, of the thermalization timescale of rotational modes, and of hadronic mechanisms to produce global polarization. © 2021 American Physical Society.

According to first-principle lattice QCD calculations, the transition from quark-gluon plasma to hadronic matter is a smooth crossover in the region μB≤Tc. In this range the ratio, C6/C2, of net-baryon distributions are predicted to be negative. In this Letter, we report the first measurement of the midrapidity net-proton C6/C2 from 27, 54.4, and 200 GeV Au+Au collisions at the Relativistic Heavy Ion Collider (RHIC). The dependence on collision centrality and kinematic acceptance in (pT, y) are analyzed. While for 27 and 54.4 GeV collisions the C6/C2 values are close to zero within uncertainties, it is observed that for 200 GeV collisions, the C6/C2 ratio becomes progressively negative from peripheral to central collisions. Transport model calculations without critical dynamics predict mostly positive values except for the most central collisions within uncertainties. These observations seem to favor a smooth crossover in the high-energy nuclear collisions at top RHIC energy. © 2021 American Physical Society.

Reentrance, the return of a system from an ordered phase to a previously encountered less-ordered one as a controlled parameter is continuously varied, is a recurring theme found in disparate physical systems, yet its microscopic cause is often not investigated thoroughly. Here, through detailed characterization and theoretical modeling, we uncover the microscopic mechanism behind reentrance in the strongly frustrated pyrochlore antiferromagnet Er2Sn2O7. We use single crystal heat capacity measurements to expose that Er2Sn2O7 exhibits multiple instances of reentrance in its magnetic field B vs temperature T phase diagram for magnetic fields along three cubic high symmetry directions. Through classical Monte Carlo simulations, mean field theory, and classical linear spin-wave expansions, we argue that the origins of the multiple occurrences of reentrance observed in Er2Sn2O7 are linked to soft modes. These soft modes arise from phase competition and enhance thermal fluctuations that entropically stabilize a specific ordered phase, resulting in an increased transition temperature for certain field values and thus the reentrant behavior. Our work represents a detailed examination into the mechanisms responsible for reentrance in a frustrated magnet and may serve as a template for the interpretation of reentrant phenomena in other physical systems. © 2021 American Physical Society.

We measure the absolute proper motion of Leo I using a WFPC2/HST data set that spans up to 10 yr to date the longest time baseline utilized for this satellite. The measurement relies on ∼2300 Leo I stars located near the center of light of the galaxy; the correction to absolute proper motion is based on 174 Gaia EDR3 stars and 10 galaxies. Having generated highly precise, relative proper motions for all Gaia EDR3 stars in our WFPC2 field of study, our correction to the absolute EDR3 system does not rely on these Gaia stars being Leo I members. This new determination also benefits from a recently improved astrometric calibration of WFPC2. The resulting proper-motion value, (μ α , μ δ ) = (-0.007 0.035, - 0.119 0.026) mas yr-1 is in agreement with recent, large-area, Gaia EDR3-based determinations. We discuss all the recent measurements of Leo I's proper motion and adopt a combined, multistudy average of (μ α 3 meas,μ δ 3 meas)=(-0.036±0.016,-0.130±0.010) mas yr-1. This value of absolute proper motion for Leo I indicates its orbital pole is well aligned with that of the vast polar structure, defined by the majority of the brightest dwarf spheroidal satellites of the Milky Way. © 2021. The Author(s). Published by the American Astronomical Society.

The James Webb Space Telescope will be able to probe the atmospheres and surface properties of hot, terrestrial planets via emission spectroscopy. We identify 18 potentially terrestrial planet candidates detected by the Transiting Exoplanet Survey Satellite (TESS) that would make ideal targets for these observations. These planet candidates cover a broad range of planet radii (R p ∼0.6-2.0R ) and orbit stars of various magnitudes (K s = 5.78-10.78, V = 8.4-15.69) and effective temperatures (T eff ∼3000-6000 K). We use ground-based observations collected through the TESS Follow-up Observing Program (TFOP) and two vetting tools - DAVE and TRICERATOPS - to assess the reliabilities of these candidates as planets. We validate 13 planets: TOI-206 b, TOI-500 b, TOI-544 b, TOI-833 b, TOI-1075 b, TOI-1411 b, TOI-1442 b, TOI-1693 b, TOI-1860 b, TOI-2260 b, TOI-2411 b, TOI-2427 b, and TOI-2445 b. Seven of these planets (TOI-206 b, TOI-500 b, TOI-1075 b, TOI-1442 b, TOI-2260 b, TOI-2411 b, and TOI-2445 b) are ultra-short-period planets. TOI-1860 is the youngest (133 ± 26 Myr) solar twin with a known planet to date. TOI-2260 is a young (321 ± 96 Myr) G dwarf that is among the most metal-rich ([Fe/H] = 0.22 ± 0.06 dex) stars to host an ultra-short-period planet. With an estimated equilibrium temperature of 1/42600 K, TOI-2260 b is also the fourth hottest known planet with R p ¡ 2 R . © 2022. The Author(s). Published by the American Astronomical Society.

We discuss the design, construction, and operation of a new intensity interferometer, based on the campus of Southern Connecticut State University in New Haven, Connecticut. While this paper will focus on observations taken with an original two-telescope configuration, the current instrumentation consists of three portable 0.6 m Dobsonian telescopes with single-photon avalanche diode detectors located at the Newtonian focus of each telescope. Photons detected at each station are time stamped and read out with timing correlators that can give cross-correlations in timing to a precision of 48 ps. We detail our observations to date with the system, which has now been successfully used at our university in 16 nights of observing. Components of the instrument were also deployed on one occasion at Lowell Observatory, where the Perkins and Hall telescopes were made to function as an intensity interferometer. We characterize the performance of the instrument in detail. In total, the observations indicate the detection of a correlation peak at the level of 6.76σ when observing unresolved stars, and consistency with partial or no detection when observing at a baseline sufficient to resolve the star. Using these measurements, we conclude that the angular diameter of Arcturus is larger than 15 mas and that of Vega is between 0.8 and 17 mas. While the uncertainties are large at this point, both results are consistent with measures from amplitude-based long baseline optical interferometers. © 2022. The American Astronomical Society. All rights reserved.

We report on the measurements of directed flow v1 and elliptic flow v2 for hadrons (π±, K±, KS0, p, ϕ, Λ and Ξ−) from Au+Au collisions at sNN=3 GeV and v2 for (π±, K±, p and p‾) at 27 and 54.4 GeV with the STAR experiment. While at the two higher energy midcentral collisions the number-of-constituent-quark (NCQ) scaling holds, at 3 GeV the v2 at midrapidity is negative for all hadrons and the NCQ scaling is absent. In addition, the v1 slopes at midrapidity for almost all observed hadrons are found to be positive, implying dominant repulsive baryonic interactions. The features of negative v2 and positive v1 slope at 3 GeV can be reproduced with a baryonic mean-field in transport model calculations. These results imply that the medium in such collisions is likely characterized by baryonic interactions. © 2022 The Author(s)

In high-energy heavy-ion collisions, partonic collectivity is evidenced by the constituent quark number scaling of elliptic flow anisotropy for identified hadrons. A breaking of this scaling and dominance of baryonic interactions is found for identified hadron collective flow measurements in sNN = 3 GeV Au+Au collisions. In this paper, we report measurements of the first- and second-order azimuthal anisotropic parameters, v1 and v2, of light nuclei (d, t, 3He, 4He) produced in sNN = 3 GeV Au+Au collisions at the STAR experiment. An atomic mass number scaling is found in the measured v1 slopes of light nuclei at mid-rapidity. For the measured v2 magnitude, a strong rapidity dependence is observed. Unlike v2 at higher collision energies, the v2 values at mid-rapidity for all light nuclei are negative and no scaling is observed with the atomic mass number. Calculations by the Jet AA Microscopic Transport Model (JAM), with baryonic mean-field plus nucleon coalescence, are in good agreement with our observations, implying baryonic interactions dominate the collective dynamics in 3 GeV Au+Au collisions at RHIC. © 2022 The Author