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Metastasis is the leading cause of mortalities in cancer patients due to the spreading of cancer cells to various organs. Detecting cancer and identifying its metastatic potential at the early stage is important. This may be achieved based on the quantification of the key biomolecular components within tissues and cells using recent optical spectroscopic techniques. The aim of this study was to develop a noninvasive label-free optical biopsy technique to retrieve the characteristic molecular information for detecting different metastatic potentials of prostate cancer cells. Herein we report using native fluorescence (NFL) spectroscopy along with machine learning (ML) to differentiate prostate cancer cells with different metastatic abilities. The ML algorithms including principal component analysis (PCA) and nonnegative matrix factorization (NMF) were used for dimension reduction and feature detection. The characteristic component spectra were used to identify the key biomolecules that are correlated with metastatic potentials. The relative concentrations of the molecular spectral components were retrieved and used to classify the cancer cells with different metastatic potentials. A multi-class classification was performed using support vector machines (SVMs). The NFL spectral data were collected from three prostate cancer cell lines with different levels of metastatic potentials. The key biomolecules in the prostate cancer cells were identified to be tryptophan, reduced nicotinamide adenine dinucleotide (NADH) and hypothetically lactate as well. The cancer cells with different metastatic potentials were classified with high accuracy using the relative concentrations of the key molecular components. The results suggest that the changes in the relative concentrations of these key fluorophores retrieved from NFL spectra may present potential criteria for detecting prostate cancer cells of different metastatic abilities.

We conducted speckle imaging observations of 53 stellar systems that were members of long-term radial velocity (RV) monitoring campaigns and exhibited substantial accelerations indicative of planetary or stellar companions in wide orbits. Our observations were made with blue and red filters using the Differential Speckle Survey Instrument at Gemini-South and the NN-Explore Exoplanet Stellar Speckle Imager at the WIYN telescope. The speckle imaging identifies eight luminous companions within 2" of the primary stars. In three of these systems-HD 1388, HD 87359, and HD 104304-the properties of the imaged companion are consistent with the RV measurements, suggesting that these companions may be associated with the primary and the cause of the RV variation. For all 53 stellar systems, we derive differential magnitude limits (i.e., contrast curves) from the imaging. We extend this analysis to include upper limits on companion mass in systems without imaging detections. In 25 systems, we rule out companions with masses greater than 0.2 M⊙, suggesting that the observed RV signals are caused by late-M dwarfs or substellar (potentially planetary) objects. On the other hand, the joint RV and imaging analysis almost entirely rules out planetary explanations of the RV signal for HD 19522 and suggests that the companion must have an angular separation below a few tenths of an arcsecond. This work highlights the importance of combined RV and imaging observations for characterizing the outer regions of nearby planetary systems. © 2021 Institute of Physics Publishing. All rights reserved.

We present high-resolution speckle interferometric imaging observations of TESS exoplanet host stars using the NN-EXPLORE Exoplanet and Stellar Speckle Imager instrument at the 3.5 m WIYN telescope. Eight TESS objects of interest that were originally discovered by Kepler were previously observed using the Differential Speckle Survey Instrument. Speckle observations of 186 TESS stars were carried out, and 45 (24%) likely bound companions were detected. This is approximately the number of companions we would expect to observe given the established 46% binarity rate in exoplanet host stars. For the detected binaries, the distribution of stellar mass ratio is consistent with that of the standard Raghavan distribution and may show a decrease in high-q systems as the binary separation increases. The distribution of binary orbital periods, however, is not consistent with the standard Ragahavan model, and our observations support the premise that exoplanet-hosting stars with binary companions have, in general, wider orbital separations than field binaries. We find that exoplanet-hosting binary star systems show a distribution peaking near 100 au, higher than the 40–50 au peak that is observed for field binaries. This fact led to earlier suggestions that planet formation is suppressed in close binaries.

We present the visual orbits of two long-period spectroscopic binary stars, HD 8374 and HD 24546, using interferometric observations acquired with the CHARA Array and the Palomar Testbed Interferometer. We also obtained new radial velocities from echelle spectra using the APO 3.5 m and Fairborn 2.0 m telescopes. By combining the visual and spectroscopic observations, we solve for the full, three-dimensional orbits and determine the stellar masses and distances to within 3% uncertainty. We then estimate the effective temperature and radius of each component star through Doppler tomography and spectral energy distribution analyses, in order to compare the observed stellar parameters to the predictions of stellar evolution models. For HD 8374, we find masses of M 1 = 1.636 ± 0.050M ⊙ and M 2 = 1.587 ± 0.049M ⊙, radii of R 1 = 1.84 ± 0.05R ⊙ and R 2 = 1.66 ± 0.12R ⊙, temperatures of K and K, and an estimated age of 1.0 Gyr. For HD 24546, we find masses of M 1 = 1.434 ± 0.014M ⊙ and M 2 = 1.409 ± 0.014M ⊙, radii of R 1 = 1.67 ± 0.06R ⊙ and R 2 = 1.60 ± 0.10R ⊙, temperatures of K and K, and an estimated age of 1.4 Gyr. HD 24546 is therefore too old to be a member of the Hyades cluster, despite its physical proximity to the group.

According to the CPT theorem, which states that the combined operation of charge conjugation, parity transformation and time reversal must be conserved, particles and their antiparticles should have the same mass and lifetime but opposite charge and magnetic moment. Here, we test CPT symmetry in a nucleus containing a strange quark, more specifically in the hypertriton. This hypernucleus is the lightest one yet discovered and consists of a proton, a neutron and a Λ hyperon. With data recorded by the STAR detector1–3 at the Relativistic Heavy Ion Collider, we measure the Λ hyperon binding energy BΛ for the hypertriton, and find that it differs from the widely used value4 and from predictions5–8, where the hypertriton is treated as a weakly bound system. Our results place stringent constraints on the hyperon–nucleon interaction9,10 and have implications for understanding neutron star interiors, where strange matter may be present11. A precise comparison of the masses of the hypertriton and the antihypertriton allows us to test CPT symmetry in a nucleus with strangeness, and we observe no deviation from the expected exact symmetry.

Based on Visible Resonance Raman (VRR) method, we have developed a novel label-free portable VRR LRR2000 Raman analyzer with a portable fiber-optic probe and used it for the classification of human gliomas ex vivo and for the analysis of changes in tumor chemical compositions in molecular level. The purpose of this study was to examine the performance of the LRR2000 Raman analyzer as an optical biopsy tool for detecting human brain tumors compared to the commercial laboratory HR800 and WITec300 micro confocal Raman spectroscopy instruments. As of 2018, a total 1,938 VRR spectra were collected using LRR2000, HR800 and WITec300 Raman system, ex vivo. Identification of the four grades of glioma tumors and control tissues was performed based on the characteristic native molecular fingerprints. LRR2000 demonstrated consistent diagnostic results with HR800 and WITec300 Raman systems. LRR2000 showed the advantages of high speed, convenience and low cost compared to the two confocal micro Raman systems. Using artificial intelligence (AI)-based analysis of part of the data, the cross-validated accuracy for identifying glioma tumors is ~90% compared with gold standard histopathology examination.

The STAR Collaboration at the Relativistic Heavy Ion Collider reports the first measurement of inclusive jet production in peripheral and central Au+Au collisions at √sNN=200 GeV. Jets are reconstructed with the anti-kT algorithm using charged tracks with pseudorapidity |η|<1.0 and transverse momentum 0.2<pchT,jet<30 GeV/c, with jet resolution parameter R=0.2, 0.3, and 0.4. The large background yield uncorrelated with the jet signal is observed to be dominated by statistical phase space, consistent with a previous coincidence measurement. This background is suppressed by requiring a high-transverse-momentum (high-pT) leading hadron in accepted jet candidates. The bias imposed by this requirement is assessed, and the pT region in which the bias is small is identified. Inclusive charged-particle jet distributions are reported in peripheral and central Au+Au collisions for 5<pchT,jet<25 GeV/c and 5<pchT,jet<30 GeV/c, respectively. The charged-particle jet inclusive yield is suppressed for central Au+Au collisions, compared to both the peripheral Au+Au yield from this measurement and to the pp yield calculated using the PYTHIA event generator. The magnitude of the suppression is consistent with that of inclusive hadron production at high pT and that of semi-inclusive recoil jet yield when expressed in terms of energy loss due to medium-induced energy transport. Comparison of inclusive charged-particle jet yields for different values of R exhibits no significant evidence for medium-induced broadening of the transverse jet profile for R <0.4 in central Au+Au collisions. The measured distributions are consistent with theoretical model calculations that incorporate jet quenching.

We report on new measurements of inclusive J/ψ polarization at midrapidity in p+p collisions at √s=200 GeV by the STAR experiment at the Relativistic Heavy Ion Collider. The polarization parameters, λθ, λϕ, and λθϕ, are measured as a function of transverse momentum (pT) in both the helicity and Collins-Soper (CS) reference frames within pT<10 GeV/c. Except for λθ in the CS frame at the highest measured pT, all three polarization parameters are consistent with 0 in both reference frames without any strong pT dependence. Several model calculations are compared with data, and the one using the Color Glass Condensate effective field theory coupled with nonrelativistic QCD gives the best overall description of the experimental results, even though other models cannot be ruled out due to experimental uncertainties.

We present a measurement of the first-order azimuthal anisotropy v1 of deuterons from Au+Au collisions at √sNN=7.7, 11.5, 14.5, 19.6, 27, and 39 GeV recorded with the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The energy dependence of the v1(y) slope, dv1/dy|y=0, for deuterons, where y is the rapidity, is extracted for semicentral collisions (10%–40% centrality) and compared with that of protons. While the v1(y) slopes of protons are generally negative for √sNN>10GeV, those for deuterons are consistent with zero, a strong enhancement of the v1(y) slope of deuterons is seen at the lowest collision energy (the largest baryon density) at √sNN=7.7GeV. In addition, we report the transverse momentum dependence of v1 for protons and deuterons. The experimental results are compared with transport and coalescence models.

We present STAR measurements of strange hadron (K0S, Λ, ¯¯¯Λ, Ξ−, ¯¯¯Ξ+, Ω−, ¯¯¯Ω+, and ϕ) production at midrapidity (|y|<0.5) in Au+Au collisions at √sNN = 7.7–39 GeV from the Beam Energy Scan Program at the Relativistic Heavy Ion Collider (RHIC). Transverse-momentum spectra, averaged transverse mass, and the overall integrated yields of these strange hadrons are presented versus the centrality and collision energy. Antibaryon-to-baryon ratios (¯¯¯Λ/Λ, ¯¯¯Ξ+/Ξ−, ¯¯¯Ω+/Ω−) are presented as well and used to test a thermal statistical model and to extract the temperature normalized strangeness and baryon chemical potentials at hadronic freeze-out (μB/Tch and μS/Tch) in central collisions. Strange baryon-to-pion ratios are compared to various model predictions in central collisions for all energies. The nuclear modification factors (RCP) and antibaryon-to-meson ratios as a function of transverse momentum are presented for all collision energies. The K0S RCP shows no suppression for pT up to 3.5 GeV/c at energies of 7.7 and 11.5 GeV. The ¯¯¯Λ/K0S ratio also shows baryon-to-meson enhancement at intermediate pT (≈2.5 GeV/c) in central collisions at energies above 19.6 GeV. Both observations suggest that there is likely a change of the underlying strange quark dynamics at collision energies below 19.6 GeV.

The measurements of particle multiplicity distributions have generated considerable interest in understanding the fluctuations of conserved quantum numbers in the quantum chromodynamics (QCD) hadronization regime, in particular near a possible critical point and near the chemical freeze-out. Net-protons and net-kaons have been used as proxies for the net-baryon number and net-strangeness, respectively. We report the measurement of efficiency- and centrality-bin width-corrected cumulant ratios (C2/C1, C3/C2) of net-Λ distributions, in the context of both strangeness and baryon number conservation, as a function of collision energy, centrality, and rapidity. The results are for Au+Au collisions at five beam energies (√sNN=19.6, 27, 39, 62.4, and 200 GeV) recorded with the Solenoidal Tracker at RHIC (STAR). We compare our results to the Poisson and negative binomial (NBD) expectations, as well as to ultrarelativistic quantum molecular dynamics (UrQMD) and hadron resonance gas (HRG) model predictions. Both NBD and Poisson baselines agree with data within the statistical and systematic uncertainties. UrQMD describes the measured net-ΛC1 and C3 at 200 GeV reasonably well but deviates from C2, and the deviation increases as a function of collision energy. The ratios of the measured cumulants show no features of critical fluctuations. The chemical freeze-out temperatures extracted from a recent HRG calculation, which was successfully used to describe the net-proton, net-kaon, and net-charge data, indicate Λ freeze-out conditions similar to those of kaons. However, large deviations are found when comparing with temperatures obtained from net-proton fluctuations. The net-Λ cumulants show a weak but finite dependence on the rapidity coverage in the acceptance of the detector, which can be attributed to quantum number conservation.

Particle production sensitive to nonfactorizable and nonperturbative processes that contribute to the underlying event associated with a high transverse momentum (pT) jet in proton+proton collisions at √s=200 GeV is studied with the STAR detector. Each event is divided into three regions based on the azimuthal angle with respect to the highest-pT jet direction: in the leading jet direction (“Toward”), opposite to the leading jet (“Away”), and perpendicular to the leading jet (“Transverse”). In the Transverse region, the average charged particle density is found to be between 0.4 and 0.6 and the mean transverse momentum, ⟨pT⟩, between 0.5 and 0.7 GeV/c for particles with pT>0.2 GeV/c at mid-pseudorapidity (|η|<1) and jet pT>15 GeV/c. Both average particle density and ⟨pT⟩ depend weakly on the leading jet pT. Closer inspection of the Transverse region hints that contributions to the underlying event from initial- and final-state radiation are significantly smaller in these collisions than at the higher energies, up to 13 TeV, recorded at the LHC. Underlying event measurements associated with a high-pT jet will contribute to our understanding of QCD processes at hard and soft scales at RHIC energies, as well as provide constraints to modeling of underlying event dynamics.

We report systematic measurements of bulk properties of the system created in Au+Au collisions at √sNN=14.5 GeV recorded by the STAR detector at the Relativistic Heavy Ion Collider (RHIC). The transverse momentum spectra of π±, K±, and p(¯p) are studied at midrapidity (|y|<0.1) for nine centrality intervals. The centrality, transverse momentum (pT), and pseudorapidity (η) dependence of inclusive charged particle elliptic flow (v2), and rapidity-odd charged particles directed flow (v1) results near midrapidity are also presented. These measurements are compared with the published results from Au+Au collisions at other energies, and from Pb+Pb collisions at √sNN=2.76 TeV. The results at √sNN=14.5 GeV show similar behavior as established at other energies and fit well in the energy dependence trend. These results are important as the 14.5-GeV energy fills the gap in μB, which is of the order of 100 MeV, between √sNN=11.5 and 19.6 GeV. Comparisons of the data with UrQMD and AMPT models show poor agreement in general.

In this letter, measurements of the shared momentum fraction (zg) and the groomed jet radius (Rg), as defined in the SoftDrop algorithm, are reported in p+p collisions at s=200 GeV collected by the STAR experiment. These substructure observables are differentially measured for jets of varying resolution parameters from R=0.2−0.6 in the transverse momentum range 15<pT,jet<60 GeV/c. These studies show that, in the pT,jet range accessible at s=200 GeV and with increasing jet resolution parameter and jet transverse momentum, the zg distribution asymptotically converges to the DGLAP splitting kernel for a quark radiating a gluon. The groomed jet radius measurements reflect a momentum-dependent narrowing of the jet structure for jets of a given resolution parameter, i.e., the larger the pT,jet, the narrower the first splitting. For the first time, these fully corrected measurements are compared to Monte Carlo generators with leading order QCD matrix elements and leading log in the parton shower, and to state-of-the-art theoretical calculations at next-to-leading-log accuracy. We observe that PYTHIA 6 with parameters tuned to reproduce RHIC measurements is able to quantitatively describe data, whereas PYTHIA 8 and HERWIG 7, tuned to reproduce LHC data, are unable to provide a simultaneous description of both zg and Rg, resulting in opportunities for fine parameter tuning of these models for p+p collisions at RHIC energies. We also find that the theoretical calculations without non-perturbative corrections are able to qualitatively describe the trend in data for jets of large resolution parameters at high pT,jet, but fail at small jet resolution parameters and low jet transverse momenta.

Flow harmonics (vn) of the Fourier expansion for the azimuthal distributions of hadrons are commonly employed to quantify the azimuthal anisotropy of particle production relative to the collision symmetry planes. While lower order Fourier coefficients (v2 and v3) are more directly related to the corresponding eccentricities of the initial state, the higher-order flow harmonics (vn>3) can be induced by a mode-coupled response to the lower-order anisotropies, in addition to a linear response to the same-order anisotropies. These higher-order flow harmonics and their linear and mode-coupled contributions can be used to more precisely constrain the initial conditions and the transport properties of the medium in theoretical models. The multiparticle azimuthal cumulant method is used to measure the linear and mode-coupled contributions in the higher-order anisotropic flow, the mode-coupled response coefficients, and the correlations of the event plane angles for charged particles as functions of centrality and transverse momentum in Au+Au collisions at nucleon-nucleon center-of-mass energy sNN= 200 GeV. The results are compared to similar LHC measurements as well as to several viscous hydrodynamic calculations with varying initial conditions.

We report results on the total and elastic cross sections in proton-proton collisions at s=200 GeV obtained with the Roman Pot setup of the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The elastic differential cross section was measured in the squared four-momentum transfer range 0.045≤−t≤0.135 GeV2. The value of the exponential slope parameter B of the elastic differential cross section dσ/dt∼e−Bt in the measured −t range was found to be B=14.32±0.09(stat.)−0.28+0.13(syst.) GeV−2. The total cross section σtot, obtained from extrapolation of the dσ/dt to the optical point at −t=0, is σtot=54.67±0.21(stat.)−1.38+1.28(syst.) mb. We also present the values of the elastic cross section σel=10.85±0.03(stat.)−0.41+0.49(syst.) mb, the elastic cross section integrated within the STAR t-range σeldet=4.05±0.01(stat.)−0.17+0.18(syst.) mb, and the inelastic cross section σinel=43.82±0.21(stat.)−1.44+1.37(syst.) mb. The results are compared with the world data.

The Kepler mission and subsequent ground-based follow-up observations have revealed a number of exoplanet host stars with nearby stellar companions. This study presents speckle observations of 57 Kepler objects of interest (KOIs) that are also double stars, each observed over a 3-8 yr period, which has allowed us to track their relative motions with high precision. Measuring the position angle and separation of the companion with respect to the primary can help determine if the pair exhibits common proper motion, indicating it is likely to be a bound binary system. We report on the motions of 34 KOIs that have close stellar companions, three of which are triple stars, for a total of 37 companions studied. Eighteen of the 34 systems are confirmed exoplanet hosts, including one triple star, while four other systems have been subsequently judged to be false positives and twelve are yet to be confirmed as planet hosts. We find that 21 are most likely to be common proper motion pairs, 4 are line-of-sight companions, and 12 are of an uncertain disposition at present. The fraction of the confirmed exoplanet host systems that are common proper motion pairs is approximately 86% in this sample. In this subsample, the planets are exclusively found with periods of less than 110 days, so that in all cases the stellar companion is found at a much larger separation from the planet host star than the planet itself. A preliminary period-radius relation for the confirmed planets in our sample suggests no obvious differences at this stage with the full sample of known exoplanets. © 2020. The American Astronomical Society. All rights reserved.

We report the discovery by the ground-based Hungarian-made Automated Telescope Network (HATNet) survey of the transiting exoplanet HAT-P-68b, which has a mass of 0.724 ± 0.043 MJ, and radius of 1.072 ± 0.012 RJ. The planet is in a circular P = 2.2984 day orbit around a moderately bright V = 13.937 ± 0.030 magnitude K-dwarf star of mass ${0.673}_{-0.014}^{+0.020}$ M⊙, and radius 0.6726 ± 0.0069 R⊙. The planetary nature of this system is confirmed through follow-up transit photometry obtained with the Fred L. Whipple Observatory (FLWO) 1.2 m telescope, high-precision radial velocities measured using Keck I/High Resolution Echelle Spectrometer (HIRES), FLWO 1.5 m/Tillinghast Reflector Echelle Spectrograph (TRES), and Observatoire de Haute-Provence (OHP) 1.9 m/Sophie, and high-spatial-resolution speckle imaging from WIYN 3.5 m/DSSI. HAT-P-68 is at an ecliptic latitude of +3° and outside the field of view of both the NASA Transiting Exoplanet Survey Satellite primary mission and the K2 mission. The large transit depth of 0.036 mag (r band) makes HAT-P-68b a promising target for atmospheric characterization via transmission spectroscopy.

Machine learning algorithms were used to classify and analyze spectral data collected by visible resonance Raman spectroscopy to distinguish normal human brain tissue and glioma tumor tissues at different grades and show promising results. © OSA 2020 © 2020 The Author(s)

High transverse momentum ( ) particle production is suppressed owing to the parton (jet) energy loss in the hot dense medium created in relativistic heavy-ion collisions. Redistribution of energy at low-to-modest has been difficult to measure, owing to large anisotropic backgrounds. We report a data-driven method for background evaluation and subtraction, exploiting the away-side pseudorapidity gaps, to measure the jetlike correlation shape in Au+Au collisions at GeV in the STAR experiment. The correlation shapes, for trigger particles and various associated particle ranges within , are consistent with Gaussians, and their widths increase with centrality. The results indicate jet broadening in the medium created in central heavy-ion collisions.