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Prior exposure of isolated perifused rat islets to the monokine interleukin-1 (IL-1) amplifies their subsequent insulin secretory response to 10 mM glucose. This potentiating effect of the monokine is dose dependent, lasts for at least 45 min after IL-1 removal from the medium, and is not confined to glucose; IL-1 also potentiates the insulin secretory responses to tolbutamide and glyceraldehyde. IL-1 exposure of islets incubated with myo-[2†3H]inositol to label their phosphoinositides (PI) results in an increase in [3H]inositol efflux, an event that persists long after removal of IL-1 from the medium. Direct measurements of labeled inositol phosphate accumulation substantiate the concept that this sustained [3H] inositol efflux response is the direct result of a sustained increase in PI hydrolysis. These results expand the list of compounds that induce time-dependent potentiation in islets to include IL-1. This action of the monokine, mediated at least in part by Pi-derived second messenger molecules, may contribute to its postulated effects on insulin and glucose homeostasis. © 1989 by The Endocrine Society.
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Little research has been done to document the value of using nursing diagnosis in home care and the impact that increased acuity levels have had in diagnostic selection. Nursing diagnosis documentation in home care was examined to see whether it had a relation to select client and visit pattern variables. This retrospective chart audit, which piloted a newly developed instrument called the Home Care Audit Tool, utilized a sample of 199 closed records of a large midwestem Visiting Nurse Association. The mean age of the client population was 76 years, with 64% female. There were 269 initial nursing diagnoses cited in the sample records, averaging 1.75 diagnoses per case. The number of recorded visits increased when select nursing diagnoses were cited together in a single case. © 1994, Taylor & Francis Group, LLC. All rights reserved.
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When establishing Nursing Ethics Committees (NECs), statewide nursing organizations play an important role in developing and disseminating resources. The Connecticut Nurses Association Ethics and Human Rights Committee surveyed 85 healthcare facilities to identify active NECs. Representatives facilitated other committees by providing guidelines and assistance to those agencies developing NECs — the ultimate goal. © 1994 by Springhouse Corporation.
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Meeting students’ learning needs in acute care settings is challenging. The authors discuss dual assignment in the pediatric setting with beginning nursing students. © 1992 Lippincott-Raven Publishers.
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Data from an open-ended questionnaire and the comments section of a structured questionnaire were combined and ana-lyzed to determine the challenges faced and alterations in usual daily activities required by mothers caring for a young child at home in a body cast. The sample consisted of 35 mothers who identified themselves as the primary care givers of a child in a body cast. The challenges of caring for a child in a body cast required major adjustments in almost every aspect of the mothers' lives, including household activities, social and community activities, child care activities, personal care activities, occupational activities, and educational activities. © 1995 National Association of Orthopaedic Nurses.
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Technologic advances are changing hospice home care. A case study explores the clinical dilemmas and illustrates the educational and research agendas required to resolve them.
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Hospice providers and policy makers are currently evaluating the emerging patterns of hospice care, especially regarding cost containment considerations. This study compared patterns of care for two groups of hospice homecare clients–one group, which received only homecare services for the duration of the hospice career; the other, which received both hospice homecare and inpatient services. The groups were significantly different on clinical parameters, number of homecare episodes, survival rate, and place of death. The impact of policy structures on continuity of care and service equity are discussed. Copyright © 1986, Wiley Blackwell. All rights reserved
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