Your search

Triple-negative breast cancer (TNBC) is an aggressive subset of breast cancer that is more common in African-American and Hispanic women. Early detection followed by intensive treatment is critical to improving poor survival rates. The current standard to diagnose TNBC from histopathology of biopsy samples is invasive and time-consuming. Imaging methods such as mammography and magnetic resonance (MR) imaging, while covering the entire breast, lack the spatial resolution and specificity to capture the molecular features that identify TNBC. Two nonlinear optical modalities of second harmonic generation (SHG) imaging of collagen, and resonance Raman spectroscopy (RRS) potentially offer novel rapid, label-free detection of molecular and morphological features that characterize cancerous breast tissue at subcellular resolution. In this study, we first applied MR methods to measure the whole-tumor characteristics of metastatic TNBC (4T1) and nonmetastatic estrogen receptor positive breast cancer (67NR) models, including tumor lactate concentration and vascularity. Subsequently, we employed for the first time in vivo SHG imaging of collagen and ex vivo RRS of biomolecules to detect different microenvironmental features of these two tumor models. We achieved high sensitivity and accuracy for discrimination between these two cancer types by quantitative morphometric analysis and nonnegative matrix factorization along with support vector machine. Our study proposes a new method to combine SHG and RRS together as a promising novel photonic and optical method for early detection of TNBC.

Heteronormativity, the “privileging of heterosexuality through its normalization” (Jackson, 2006, p. 109), causes confusion and anxiety for many lesbian, gay, bisexual, and asexual preservice teachers as they consider how they will talk about their lives with students. This article explores how preservice teachers have experienced the normalization of heterosexuality and the ways in which these experiences will shape their professional practices. Focus group and follow up interviews with lesbian, gay, bisexual, and asexual preservice teachers were analyzed using a constant comparison method. Findings suggest that participants’ professional vision was largely a response to heteronormativity. They wanted to be out, be role models, and create safe spaces; yet they felt unable to achieve this vision in what they perceived as heteronormative school climates. Implications for teacher preparation programs and policies include the importance of equipping all preservice teachers to identify and disrupt heteronormativity in schools.

Many radio collections within the United States are maintained in more informal program libraries and archives in hundreds of geographically dispersed broadcasting stations throughout the country. To assess the full extent of this problem and real risk posed to station-owned radio collections, this article assesses the results of a survey administered across twenty-seven nonprofit and commercial stations or corporate parent companies. Nonprofit stations, its findings suggest, are more likely to actively maintain their archives and do so in a manner that shows awareness of current archival standards, whereas commercial stations are less likely to exert active stewardship over their collections. © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

Extreme climatic events including marine heatwaves (MHWs) are becoming more frequent and severe in the Anthropocene. However, our understanding of how these events affect population dynamics of ecologically important species is limited, in part because extreme events are rare and difficult to predict. Here, we quantified the occurrence and severity of MHWs over 60 years in warm range edge kelp forests on both sides of the North Atlantic. The cumulative annual intensity of MHWs increased two- to four-fold during this period, coinciding with the disappearance of kelps. We experimentally demonstrated a relationship between strong and severe 2018 heatwaves and high kelp mortality in both regions. Patterns of kelp mortality were strongly linked to maximum temperature anomalies, which crossed lethal thresholds in both regions. Translocation and tagging experiments revealed similar kelp mortality rates on reefs dominated by healthy kelp forests and degraded sediment-laden algal ‘turfs’, indicating equal vulnerability to extreme events. These results suggest a mechanistic link between MHWs and broad-scale kelp loss, and highlight how warming can make ecosystem boundaries unstable, forcing shifts to undesirable ecosystem states under episodically extreme climatic conditions. © 2020, The Author(s).

The Early Pliocene Sagantole Fm. in the Gona Project area, Afar State, Ethiopia, is noted for discoveries of the early hominin Ardipithecus ramidus. A large series of fossil cercopithecid primates dated to between 4.8 and 4.3 Ma has also been collected from these sediments. In this paper, we use qualitative analysis and standard dental and postcranial measures to systematically describe the craniodental remains and tentatively allocate postcrania to taxa where we are able to. We then use these data to compare these specimens to fossil assemblages from contemporary sites, interpret their paleobiology, and discuss implications for the paleoecology of the Gona Sagantole Fm. We recognize three cercopithecid species in the Gona Sagantole Fm. Pliopapio alemui makes up approximately two-thirds of the identifiable specimens; nearly all of the rest are allocated to Kuseracolobus aramisi, and a single molar indicates the presence of a second, somewhat larger but morphologically distinct papionin. Among the Early Pliocene cercopithecids from Gona are also a number of postcranial elements. None of the postcranial remains are directly associated with any of the cranial material. Nonetheless, some of the distal humeri and proximal femora can be tentatively allocated to either Pl. alemui or K. aramisi based on a combination of size, as the latter is approximately 50% larger than the former, and morphology. If these assignments are correct, they suggest K. aramisi was primarily arboreal and similar to most extant colobines, whereas Pl. alemui was more mixed in its substrate use, being more terrestrially adapted than K. aramisi, but less so than extant Papio or Theropithecus. Thus, we interpret the predominance of Pl. alemui over K. aramisi is consistent with a somewhat more open environment at Gona than at Aramis. © 2020 Elsevier Ltd

Environmental enrichment (EE) is one experimental manipulation that induces changes in the brain. However, it is important to distinguish between physical and social components of enrichment. To this end we established four groups of rats reared in different enriched environments during the adolescent period. Our results indicate heightened social memory and increased spine density in dentate gyrus specifically in socially enriched animals. Physical enrichment increased spine density in CA1. Dopamine D2 receptor expression in hippocampus was decreased across all enrichment conditions. Altogether, our results demonstrate differing effects of physical and social enrichment, supporting an important role for environment in synaptogenesis, behavior, and dopaminergic signaling. © 2020 The Authors

What is known on the subject?: The loss of a parent for an adult can be devastating and can impact other relationships. The adult, in absence of parental love and support, may question their own identity. What this paper adds to existing knowledge?: A narrative is used to explain the adults’ experience of parental death and their new identity of being orphaned. What are the implications for practice?: Increased awareness for adults grieving the loss of a parent(s), as to the normalcy of feeling orphaned Adults grieving the death of a parent(s) are provided resources and support in addressing their grieving process. Abstract: Introduction When a parent dies during their child's adulthood, the life of the adult is altered as the familiarity of parental love and safety changes. The isolation and loneliness penetrates deeply as the orphaned adult must now navigate their world in absence of the most significant people in their lives, their parents. Aim To assist persons affected by parental death in understanding the normalcy of feeling orphaned while grieving. Method The use of a personal narrative to provide mental health support to others. Results The resumption of a routine that existed before parental death is possible, but takes time. Intermittent periods of grief can occur throughout one's life. Discussion When grief interrupts one's ability to function daily and the affected adult has relationships impacted by their parent's death, it is recommended that the adult seek mental health treatment. Implications for Practice Narratives can be used with persons affected by parental loss, to provide an example of normal versus complicated grieving and identify when mental health treatment is needed. © 2020 John Wiley & Sons Ltd

Retention and development of ethnically diverse nursing students may be more likely to occur when nursing faculty receive training on factors that can impact academic success. By understanding complex school system dynamics in low-income areas, cultural, linguistic, gender, age, religion, and ethnic differences, students’ strengths can be readily recognized, embraced, and encouraged by nursing faculty. When the necessity of equity and diversity is recognized within nursing education, this may potentially translate to retention and completion of nursing programs by nursing students from diverse backgrounds, thereby increasing diversity within the nursing profession. © 2020 Organization for Associate Degree Nursing

Background: The National Science and Technology Council developed a 5-year plan in 2013 to ensure that science, technology, engineering, and mathematics (STEM) experienced sustained growth within the United States (US). Nursing is comprised of multiple sciences that include chemistry, physics, biology, microbiology, anatomy and physiology, pharmacology, and the social and behavioral sciences of sociology, developmental lifespan psychology, and psychology. Science, technology, engineering, and math constitute the traditional STEM acronym. Nursing programs graduate nurses with both the rigorous academic coursework and diverse clinical skills necessary to provide patient care. These skills employed by nurses in the clinical setting can serve as the basis for the inclusion of the nursing profession as a STEM-designated profession by the federal government and educational institutions within the US. Problem: Currently, the US government does not acknowledge the profession of nursing as a STEM-designated profession. Acknowledgment of nursing as a STEM profession could potentially make more funding available for nursing education within the US and address nursing shortages both in clinical and academic settings. As well as position professional nurses for careers not only within the health sector but that of business and industry because of nurses’ STEM knowledge. Hence, enhancing the growth of STEM within the US and creating global market economic competitiveness with new innovation development. Approach: In the practice of nursing, nurses apply the sciences, math, and innovative technology in the assessments, diagnoses, and planning of patients’ care. Nurses implement scientifically-based interventions to treat illness and sustain human life and to ultimately evaluate the outcomes of the care provided to patients. Outcomes: Methodologies of evaluation of outcomes of patient care status post nursing interventions (ie, administration of intravenous antibiotics to treat pneumonia) are based upon rationales that have been derived from evidenced-based practice and nursing research; both originating from applied STEM knowledge. Conclusion: The formal designation by the US federal government, for nursing to be recognized as a STEM profession, can increase funding to the nursing profession and enhance the diversity of employment opportunities for nurses in industry and business. Thereby potentially decreasing nursing shortages and bringing national and worldwide recognition to nursing in both academia, industry, business, and clinical settings, as a profession contributing to the science of improvement of the health of all people through STEM knowledge. © 2019 The Authors. Nursing Forum published by Wiley Periodicals, Inc.

Schools and education in general have made an implicit and, we would assert, explicit promise to society to educate all the children in their care. Unfortunately, there are achievement gaps that illustrate how schools have broken this promise. Teacher evaluation and other accountability measures have been heralded as the answer to this problem. Educator ego threat impedes the implementation of goal-driven teacher evaluation models and, thus, ethical questions arise. To realize the noble goals of educator evaluation, leaders must attend to ethical concerns and to the human aspects of ego threat.

Purpose: The purpose of this paper is to identify the measures employed in the provision of patron services in Chinese academic libraries responding to the COVID-19 pandemic, noting the challenges and issues inherent in providing substantial services while undergoing a public health emergency. Design/methodology/approach: This paper uses an analytical survey study of 137 Chinese academic libraries using data collected through a combination of website investigation, social media access and direct correspondences. Findings: Over 94% of Chinese academic libraries released COVID-19-related information through their websites; the majority switched their service focus to partly or solely remotely online, including remote access, free electronic resources, virtual references reachable 24/7 and research support services deliverable online; services of print materials were altered to e-books for conveniences. Research limitations/implications: It should be noted that the survey was conducted from February 12 to April 5, 2020; because of the rapid updates to the library's website and social media channels, the status of their patron services are in the process of dynamic changes and that there should be many libraries that have adopted some patron service methods, but this study is difficult to cover comprehensively. In addition, patron services carried out offline by the surveyed libraries but not disclosed on the online platform could not be analyzed in a way that would be consistent with the data provided by the survey. Originality/value: By providing evidence of the current status of patron services in Chinese academic libraries during the COVID-19 pandemic, this study helps fulfill the scant empirical attention given to the impact of nationwide public health crises on academic libraries and offers new data of the best practices that help library administrators enhance the impact, efficiency and value of library services to their target community users. © 2020, Emerald Publishing Limited.

The two major impetuses to improve STEM education are the shift to online learning and increasing active learning and engagement. Although the COVID-19 pandemic necessitated a rapid shift to online learning, this shift came at the cost of losing on-ground active learning strategies. This study provides descriptive analytical information on the impact of COVID-19 as it relates to student engagement, attendance, and viewership of video-recorded lectures for a nonmajors chemistry course. After the shift online, lecture video views significantly increased and weekly attendance significantly decreased. Prior to the pandemic, on-ground engagement via an active learning activity (i.e., Plickers) was significantly associated with on-ground achievement (i.e., exam 1). However, no significant association was found between online engagement (i.e., written responses/feedback submitted via a learning management system, referred to as LMS student feedback) and online achievement (i.e., final exam), potentially because the engagement resembled a formative assessment more than an active learning activity. Nonetheless, there was tremendous value in soliciting LMS student feedback for directing the course. Throughout the online period, there was an average of 112 responses per assignment, for a total of 1,344 responses, representing roughly a third of the students. Finally, analyses revealed no significant association of on-ground and online engagement, which suggests a different subset of students engaged while on-ground vs online. Instructors should highly consider soliciting weekly feedback through low-stakes assignments to gauge student learning and improve their courses while online. Copyright © 2020 American Chemical Society and Division of Chemical Education, Inc.

To investigate if athletes’ attitudes toward athletic trainers and sport psychology consultants differ considering nature of athletic ability beliefs and previous experiences with these professionals; collegiate student-athletes (n = 114 male, n = 81 female, M age = 19.77, SD = 1.43) completed the Conceptions of the Nature of Athletic Ability Questionnaire-2 (Biddle, Wang, Chatzisarantis, & Spray, 2003), Attitudes Toward Athletic Trainers-Form (modified from the Attitudes toward Physiotherapist-Form; Arvinen-Barrow, Clement, & Bayes, 2012), and the Sport Psychology Attitudes Revised-Form (Martin, Kellman, Lavallee, & Page, 2002). Multiple analyses of variance revealed small statistically significant mean differences in attitudes considering ability beliefs, previous athletic training, and sport psychology experiences. Athletes with previous athletic training experience were less confident in their athletic trainer than those without such experience. In contrast, athletes with previous sport psychology experience were more confident in their consultant than those without such experiences. Results suggest athletes’ attitudes towards helping professionals may be partially influenced by subjective norms and expectations about the nature of such relationships.

The bacteriophage population is vast, dynamic, old, and genetically diverse. The genomics of phages that infect bacterial hosts in the phylum Actinobacteria show them to not only be diverse but also pervasively mosaic, and replete with genes of unknown function. To further explore this broad group of bacteriophages, we describe here the isolation and genomic characterization of 116 phages that infect Microbacterium spp. Most of the phages are lytic, and can be grouped into twelve clusters according to their overall relatedness; seven of the phages are singletons with no close relatives. Genome sizes vary from 17.3 kbp to 97.7 kbp, and their G+C% content ranges from 51.4% to 71.4%, compared to ~67% for their Microbacterium hosts. The phages were isolated on five different Microbacterium species, but typically do not efficiently infect strains beyond the one on which they were isolated. These Microbacterium phages contain many novel features, including very large viral genes (13.5 kbp) and unusual fusions of structural proteins, including a fusion of VIP2 toxin and a MuF-like protein into a single gene. These phages and their genetic components such as integration systems, recombineering tools, and phage-mediated delivery systems, will be useful resources for advancing Microbacterium genetics.