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We present 248 speckle observations of 43 binary and 19 trinary star systems chosen to make progress in two main areas of investigation: the fundamental properties of metal-poor stars and star formation mechanisms. The observations were taken at the Gemini North and South telescopes during the period 2015 July to 2018 April, mainly with the Differential Speckle Survey Instrument but also with a few early results from the new 'Alopeke speckle camera at Gemini North. We find that the astrometry and photometry of these observations as a whole are consistent with previous work at Gemini. We present five new visual orbits for systems important in understanding metal-poor stars, three of which have orbital periods of less than 4 yr, and we indicate the degree to which these and future observations can impact our knowledge of stellar properties and star formation. In particular, we find a decrease in mass at fixed spectral type for metal-poor stars versus their solar-metallicity analogs that is consistent with predictions that are made from current stellar models. © 2019. The American Astronomical Society. All rights reserved..

The reporting of non-Generally Accepted Accounting Principles Measures (non-GAAP) by U.S. publically traded companies is not new but it has recently come under increased scrutiny by the United States Securities and Exchange Commission (SEC). This case presents a specific example of this scrutiny in the form of Tesla, Inc.’s quarterly earnings announcements and Tesla’s subsequent correspondence with the SEC. This case requires students to answer relevant questions about GAAP vs Non GAAP reporting, generally in the form of a research memo, with references to applicable SEC regulations and guidance on the use and reporting of non-GAAP measures.

Background & Objectives: Interviewers often provide positive nonverbal feedback to reduce interviewees' anxiety. Socially anxious individuals typically harbor negative self-views discrepant with positive feedback. We examined whether nonverbal feedback and social anxiety jointly influence cortisol responses to, and performance during, interviews. Design: An experimental between-subjects design randomly assigned participants to feedback condition. Methods: Undergraduate students (N = 130) provided saliva and completed social anxiety, interview anxiety, and affective measures before a simulated interview. Following a standardized script, a confederate interviewer provided positive, ambiguous, or negative nonverbal feedback. Participants then provided saliva and completed self-focused attention and self-awareness measures. Confederate interviewers and an external rater evaluated participants' anxiety displays, assertive behavior, and performance. Results: Positive feedback decreased cortisol and improved performance for low social anxiety participants. Socially anxious participants exhibited higher cortisol but did not exhibit significant differences in performance after positive compared to negative feedback. Conclusions: Consistent with previous findings, positive feedback did not benefit socially anxious interviewees. Positive feedback increased physiological arousal relative to negative feedback but did not hinder performance among people high in social anxiety. These results provide novel information about the interactive influence of social anxiety and nonverbal interviewer feedback on arousal, self-focus, and interview performance.

Using data from the National Longitudinal Study of Adolescent Health, this study examined the impact of sexuality factors and satisfaction with partner on stress, anxiety, and depressive symptoms. Multiple regression was used to evaluate the impact of predictors such as sexuality factors and relationship satisfaction on the dependent variables: stress, anxiety, and depression. Three main results were discovered. First, sexual minority females who have lower levels of education and are dissatisfied with their relationship experience significantly higher stress, while sexual minority males do not differ from heterosexual males in terms of relationship satisfaction or stress. Second, sexual minority females who have lower levels of education and who are dissatisfied with their relationship experience significantly higher anxiety, while sexual minority males do not differ from heterosexual males in terms of relationship satisfaction or anxiety. Finally, female sexual minorities who have lower levels of education reported fluid attraction, fluid identity, dissatisfaction with their relationship, and have significantly higher depression when compared to male sexual minorities or heterosexuals. Further research should examine gender and fluidity in greater detail. © 2018, © 2018 Taylor & Francis Group, LLC.

Recovery of burn patients may be impeded by mental health problems. By gaining a better understanding of the impact that psychological factors may have on hospital length of stay, providers may be better informed to address the complex needs of burn survivors through effective and efficient practices. This systematic review summarizes existing data on the adverse psychological factors for the length of burn patients' hospitalization, and assesses the methodological quality of the extant literature on mental health conditions of burn survivors. A literature search was conducted in four electronic databases: PubMed, PsychINFO, Science Direct, and the Cumulative Index to Nursing and Allied Health Literature. Results yielded reports published between 1980 and 2016. Methodological quality was assessed by using an 11-item methodological quality score system. Seventy-four studies were identified by search; 19 articles were eligible for analysis. Findings demonstrate paucity of evidence in the area. Reports indicate longer hospital stay among burn patients with mental health problems. Substance use was the most consistent mental-health predictor of longer hospital stay. Heterogeneity in data on mental health conditions rendered impossible estimation of effect sizes of individual psychological factors on length of hospitalization. Many studies over-relied on retrospective designs, and crude indicators of psychological factors. Findings indicate that mental health problems do have an impact on the trajectory of burn recovery by increasing the length of hospital stay for burn survivors. Inpatient mental health services for burn patients are critically needed. Prospective designs, and more sensitive psychological indicators are needed for future studies.

This chapter first reviews the research and applications of nonresonance and resonance Raman spectroscopy for analysis of human brain normal and abnormal tissues. Next, special emphasis is made on our recent achievements of visible resonance Raman (VRR) technique in primary human brain tumor disease investigation and diagnosis. Visible resonance Raman (VRR) spectroscopy technique uses excitation of visible light (532 nm) to evaluate the resonant and nonresonant molecular vibrational modes in biological tissues. The VRR signal intensities are enhanced by two to three orders of magnitude for faster use in medical applications in quasi real time. VRR opens up a new stainless “molecular optics based histopathology” diagnosis approach. © 2019 Elsevier Ltd. All rights reserved.

The tactical and technical components of training become a primary emphasis, leaving less time for targeted development of physical qualities that underpin performance during the competition phase of a training program. A deemphasis on physical preparation during the in-season training phase may make athletes more susceptible to injury and decrease performance on the field. Two weeks prior to the start and one week following the conclusion of the 16-week collegiate lacrosse season, lower body force production was assessed in eight National Collegiate Athletic Association (NCAA) Division I Men’s Lacrosse athletes. Lower body force production capabilities were determined via the performance of countermovement jumps (CMJ) and drop jumps (DJ) performed on a force plate and isokinetic strength testing of the quadriceps and hamstring muscle groups across three velocities. Isokinetic strength of the hamstrings and the hamstring to quadriceps strength ratio were maintained or increased over the course of the competition phase of training. Relative peak force obtained from the CMJ and the reactive strength index from the DJ decreased significantly over the season. The maintenance of isokinetic strength and the decrease in CMJ and DJ performance may indicate the presence of neuromuscular fatigue that accumulated over the course of the season.

Dysphagia is common in hospitalized patients post-extubation and associated with poor outcomes. Laryngeal sensation is critical for airway protection and safe swallowing. However, current understanding of the relationship between laryngeal sensation and aspiration in post-extubation populations is limited. Acute respiratory failure patients requiring intensive care unit admission and mechanical ventilation received a Flexible Endoscopic Evaluation of Swallowing (FEES) within 72 h of extubation. Univariate and multivariable analyses were performed to examine the relationship between laryngeal sensation, length of intubation, and aspiration. Secondary outcomes included pharyngolaryngeal secretions, pneumonia, and diet recommendations. One-hundred and three patients met inclusion criteria. Fifty-one patients demonstrated an absent laryngeal adductor reflex (LAR). Altered laryngeal sensation correlated with the presence of secretions (p = 0.004). There was a significant interaction between the LAR, aspiration, and duration of mechanical ventilation. Altered laryngeal sensation was significantly associated with aspiration on FEES only in patients with a shorter length of intubation (p = 0.008). Patients with altered laryngeal sensation were prescribed significantly more restricted liquid (p = 0.03) and solid (p = 0.001) diets. No relationship was found between laryngeal sensation and pneumonia. There is a high prevalence of laryngeal sensory deficits in mechanically ventilated patients post-extubation. Altered laryngeal sensation was associated with secretions, aspiration, and modified diet recommendations especially in those patients with a shorter length of mechanical ventilation. These results demonstrate that laryngeal sensory abnormalities impact the development of post-extubation dysphagia.

We compare domestic architectural features in New England and the Maritime Peninsula to investigate the relationship between the adoption of horticulture and its relationship to social and settlement change during the Woodland Period. Horticulture was not practiced on the Maritime Peninsula until after European contact, despite cultural and environmental similarity to New England. In New England, horticulture has been implicated in profound social and settlement changes. However, aggregated villages, a unit typically investigated for evidence of social change, have proven elusive in the archaeological record. We compiled and analyzed a dataset of dwelling features instead of relying on identifiable villages. This novel quantitative approach uses dwelling feature shape and size as a proxy for social and settlement change, considering these changes at the scale of the house. We find that, during the Woodland Period, dwelling size was overall slightly larger in New England than on the Maritime Peninsula, but ranges heavily overlapped. After the introduction of horticulture, however, dwellings in New England grew in size overall and assumed bimodally distinct larger and smaller forms, which likely necessitated a restructuring of social and economic behavior. This pattern correlates maize horticulture with changes in social and economic lifestyle in Late Woodland New England. , Nous comparons des structures d'habitation domestiques de sites archéologiques de la Nouvelle-Angleterre et de la péninsule maritime afin d'explorer les conséquences de l'adoption généralisée de l'horticulture en termes de changements sociaux et de transformation des modes d’établissement en Nouvelle-Angleterre à la période Sylvicole. L'horticulture ne fut pas pratiquée dans la péninsule maritime avant la période du contact européen, malgré de fortes similarités culturelles et environnementales avec la Nouvelle-Angleterre. En Nouvelle-Angleterre, l'horticulture est présentée comme ayant été la source de changements sociaux profonds et d'une transformation des modes d’établissement. Au niveau archéologique cependant les sites de village font défaut, alors qu'ils constituent habituellement un repère pour l'identification et l’étude des changements sociaux; cette situation a provoqué des débats sur l'impact socio-économique de l'horticulture. Nous analysons ici un ensemble de données concernant des structures d'habitation individuelles en faisant fi de l'idée selon laquelle l’étude d'un village bien défini est nécessaire. Cette approche quantitative novatrice nous permet d'aborder la question des changements sociaux et de l’évolution des modes d’établissement à l’échelle de l'habitation, par l'intermédiaire de la forme et des dimensions des structures. Nous observons que durant la période sylvicole la taille des structures d'habitation était en général légèrement plus grande en Nouvelle-Angleterre que dans la péninsule maritime, malgré une fourchette de dimensions comparable pour les deux régions. Les habitations de la Nouvelle-Angleterre voient toutefois leur taille augmenter après l'introduction de l'horticulture, alors que se développe une division bimodale entre de grandes et de petites structures, changements rendus possibles par une probable réorganisation des comportements économiques et sociaux. Cette tendance met en corrélation la culture du maïs avec une transformation des modes de vie économiques et sociaux en Nouvelle-Angleterre durant le sylvicole supérieur.

Restraint stress (RS) induces neurotoxicity in the hippocampus, yet most of the studies have employed protracted RS (i.e., = 21 days). Binge ethanol can induce brain toxicity, an effect affected by age. It could be postulated that RS may facilitate ethanol-induced neurotoxicity, perhaps to a greater extent in adolescent vs. older subjects. We analyzed whether adolescent, adult or middle-aged male rats exposed to five episodes of RS followed, 72h later, by binge ethanol (i.e., two administrations of 2.5 g/kg ethanol) exhibited hippocampal neurotoxicity. Adolescents, but not adult or middle-aged rats, exhibited sensitivity to the neurotoxic effects of ethanol at dorsal CA2, ventral CA3 and ventral DG, and a neurotoxic effect of stress at dorsal CA1. Moreover, the combination of ethanol and stress exerted a synergistic effect upon cell degeneration at ventral CA1 and CA2, which was restricted to adolescents. Ethanol also increased cell degeneration, irrespective of age or stress, in dorsal CA3 and in dorsal DG; and ethanol and stress had, across all ages, a synergistic effect upon cell degeneration at the dorsal CA1. The greater neurotoxic response of adolescents to ethanol, stress, or ethanol+stress can put them at risk for the development of alcohol problems. Copyright © 2019 Elsevier B.V. All rights reserved.

Alcohol use is associated with a variety of negative consequences, including heightened likelihood of cognitive impairment, proclivity to alcohol use disorders (AUD), and alterations in the drinker's offspring. Children and rodents exposed to alcohol during pregnancy, or those whose fathers consumed alcohol prior to mating, often exhibit neurodevelopmental, physiological, and behavioral deficits. The present study assessed cognitive function and alcohol intake in male and female rats that were offspring of alcohol-exposed fathers. Adult male rats were exposed to alcohol or vehicle (0.0 or 2.0 g/kg, respectively; twice daily for 2 days followed by a rest day, for a total of eight alcohol or vehicle exposure days), or were left untreated and then mated with non-manipulated females. The offspring were assessed for alcohol intake, via intraoral infusion, followed by cognitive assessment via an alternating T-maze task. The results indicated that paternal ethanol exposure, prior to breeding, resulted in offspring that consumed significantly more ethanol than vehicle or untreated controls. Furthermore, the offspring of alcohol-exposed fathers exhibited a significant failure to initiate and complete the T-maze performance tests. Although, when they did engage in the tests they performed at the level of controls (i.e., 80% correct). The present results add to a growing body of literature suggesting that paternal pre-conception alcohol exposure can have deleterious effects on the offspring. Copyright © 2018 Elsevier Inc. All rights reserved.

Political leadership of various states in India is under tremendous pressure to provide instant relief to the farmers reeling under debt trap, resulting in suicides in several cases. Often, suicides by peasants are widely covered in the media which in turn sway the people’s perception about apparent indifference of the government towards the farming communities of the country. This certainly brings in concerns related to political economy revolving around judicious distribution of wealth and national income of the country. State governments of India are generally reluctant to waive off the farm loans as a matter of routine due to concomitant burden on exchequer that might adversely affect their fiscal balances. However, political parties tend to use farm loan waiver as tactics to come to power in spite of the fact that such populist measures are not good for the economy, nor do they offer a long-term solution to the age-old problem of higher degree of incidence of indebtedness among the farming communities. This article explores the antecedents and consequences of farm loan waivers and the way forward. Besides, it also reconnoitres whether the state takes such decisions as farm loan waiver purely on the basis of economics or any hidden political agenda.

Ongoing racism, structural inequity, dehumanizing institutional bureaucracies, unresponsive service delivery systems, and gaps in services for emerging needs are just some of the pervasive challenges in need of social work leadership. The multidisciplinary nature of social work practice also requires value-based leadership processes on multiple ecological levels to address the challenges inherent within social delivery systems. Social work encourages all social workers to lead these change efforts, but research on front-line social work leadership is lacking. Constructionist conceptualizations of leadership as social influence processes provide a unit of analysis to examine front-line leadership. A secondary analysis of qualitative data examining social work practice that promotes well-being and social justice revealed leadership processes in multiple social work practice settings. Findings Front-line social workers demonstrate three overarching leadership processes in their practice: challenging injustice and changing mindsets, conduit for change, and organizing resources and relationships. Applications Conceptualizing leadership as social influence processes identifies and acknowledges the leadership of front-line social workers, expanding the profession's capacity to collectively articulate and initiate change with a range of social problems and systemic challenges in organizations and communities.

This paper examines to what extent the 129 members of the Urban Public Libraries Council meet the Section 508 standards for accessibility under the Rehabilitation Act, the minimum acceptable standard for accessibility under the Americans with Disabilities Act. Using an HTML evaluation tool, WAVE, the HTML coding of the libraries’ homepages was evaluated according to the Section 508 criteria for accessibility. After one-to-one deep examination to determine the accessibility of the library websites, the results tended to mirror other studies showing that most library websites have some coding deficiencies that limit the accessibility of the websites. Notably, only 7 of the 122 libraries that were surveyed had no Section 508 errors present with their homepages.

Individuals with autism spectrum disorder (ASD) often have co-morbid anxiety and depression. Alexithymia and emotion regulation difficulties are commonly seen in individuals with ASD and in mood disorders. We hypothesized that alexithymia and emotional regulation would mediate the relationship between autistic features and anxiety/depression symptom severity. We collected data about emotional regulation, alexithymia, autistic symptoms and depression/anxiety in a sample of 64 young adults with ASD. We constructed two serial multiple mediator models, using autistic features as the independent variable and anxiety/depression symptoms as outcome variables. The serial relationship between alexithymia and emotional regulation mediated associations between autistic features and depression and anxiety, separately. The findings suggest that targeting alexithymia may benefit therapies designed to alleviate mood disorders in ASD.

Background: Increased death due to the opioid epidemic in the United States has necessitated the development of new strategies to treat addiction. Monoclonal antibodies and antidrug vaccines provide a tool that both aids addiction management and reduces the potential for overdose. Dual drug vaccines formulated by successive conjugation or by mixture have certain drawbacks. The current study examines an approach for combatting the dangers of fentanyl-laced heroin, by using a hapten with one epitope that has domains for both fentanyl and heroin. Results: We evaluated a series of nine vaccines developed from chemically contiguous haptens composed of both heroin- and fentanyl-like domains. Analysis of the results obtained by SPR and ELISA revealed trends in antibody affinity and titers for heroin and fentanyl based on epitope size and linker location. In antinociception studies, the best performing vaccines offered comparable protection against heroin as our benchmark heroin vaccine, but exhibited attenuated protection against fentanyl compared to our fentanyl vaccine. Conclusion: After thorough investigation of this strategy, we have identified key considerations for the development of a chemically contiguous heroin-fentanyl vaccine. Importantly, this is the first report of such a strategy in the opioid-drug-vaccine field.

The search for an ethical vendor who is honest and trustworthy in the exchange process is conceptualized as the Diogenes Effect, an innovative concept. In the light of this effect, the theoretical framework of the current study's model involved retail buyer responses to vendor persuasive communications. The model was tested by having a sample of retailer buyers complete a survey of information processing in the search for a product and vendor. This study innovatively links vendor communication effects to retailer buyer decision-making and evaluations by incorporating and integrating elements of Elaboration Likelihood Theory. Contributing to theory-building, it was found that when retailer buyers searched for a vendor with an ethical orientation, the result was intensified central processing of information and decreased peripheral information processing. This was especially salient when retailer buyers had greater longevity of professional experience. The next stage, information processing, led to feedback that enabled assessment of vendor trustworthiness. Finally, the research measured the level of fulfillment in the post-purchase phase. In the end, typical outcomes included the generation of favorable expectations of vendor performance, as well as the positive impact of those heightened favorable expectations on greater satisfaction with the value ultimately received from the vendor.