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The prevalence of Raynaud phenomenon (RP), defined as skin color changes on acral body segments in response to cold or stress, has been estimated to be 3-5% in population studies.1,2 In 80-90% of cases, patients are otherwise healthy and are diagnosed with primary RP.1,3
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Abstract Inhibitory Smads (I-Smads) regulate TGF-β/BMP signaling through multiple distinct mechanisms, but whether different tissues preferentially employ specific mechanisms remains unknown. To address this question, we performed structure-function analyses of the Drosophila I-Smad Dad and its vertebrate orthologs Smad6 and Smad7 in neural and wing tissues, measuring in vivo outputs of BMP signaling. We identified a critical 24-amino acid putative DNA-binding domain (DNABD) within the MH1 domain of the Drosophila I-Smad, Dad, that is essential for inhibitory function in wing tissue but unessential in neural tissue. Structural analyses revealed that ΔDNABD disrupts a beta hairpin structure homologous to R-Smad DNA-binding regions. We also found that Dad requires an intact MH1 domain to disrupt wing development, whereas either MH1 or MH2 can independently disrupt BMP signaling in motor neurons. These findings support a model where Dad functions through MH1-mediated transcriptional regulation in wing primordium, but through multiple mechanisms in neurons. Comparative analysis revealed that vertebrate I-Smad orthologs also show tissue-specific activity patterns, with structural predictions suggesting that Smad6 retains ancestral DNA-binding capacity while Smad7 has evolved enhanced MH2-mediated functions. These results reveal context-dependent mechanisms of I-Smads that further the understanding of TGF-β/BMP pathway regulation.
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How elderlies participate in social activities is a key issue in coping with aging and has an important impact on elderlies’ well-being. This paper examines the effects of different social participation patterns on the happiness of the elderlies in China. The empirical analysis was conducted based on the data from the China Household Finance Survey (CHFS) in 2015. The research results show that compared with reemployment after retirement, community governance is a more common way for retired people to be involved in social activities. We found that reemployment significantly reduces the happiness degree of the retired. Furthermore, this negative effect is more significant in samples without a formal labor contract, relatively lower education level, & senior retired people. In contrast, participating in community governance can significantly improve the happiness level of retirees, which is more essential in the sample of the medium education level and junior retirees.
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Abstract Income inequality has, in recent years, become a serious issue especially in emerging markets. This paper examines the relationship of income inequality in the Asia-Pacific and Latin America regions to several factors such as gross capital formation, corruption, and per capita gross domestic product (GDP). Using a cross-sectional dataset of 36 countries from both regions for the year 2018 and ordinary least squares regression, the paper shows that gross capital formation and the lack of corruption have a negative and significant relationship with income inequality (as represented by the Gini coefficient). In contrast, per capita GDP has a positive and significant relationship with income inequality. Policymakers who want to rein in income inequality should therefore focus on ways to reduce corruption and increase the formation of capital. This study could be of use for those who are interested in discovering and mitigating the factors that cause income inequality in the developing world.
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Abstract Bacteria in the Arthrobacter genus belong to the phylum Actinobacteria and are primarily soil-dwelling. Over 600 bacteriophages infecting Arthrobacter hosts have been isolated and sequenced, and genomic analyses show these phages to be highly diverse with mosaic genome architectures. We describe here a group of 32 Arthrobacter phages grouped in Cluster AZ, isolated on four different Arthrobacter strains all with siphoviral morphologies. The Cluster AZ phages exhibit a spectrum of diversity and can be subdivided into four subclusters. The diversity in minor tail protein and endolysin genes correlates partly with isolation host strain and may be predictive of the host range of these phages. Most of the Cluster AZ phages are temperate, form stable lysogens, and encode an integrase; however, an immunity repressor gene has not been identified. The intracluster diversity was analyzed in-depth at the whole genome level and through individual genes. As more Arthrobacter phages are isolated and analyzed they continue to provide new insights into phage evolution.
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This study aims to explore the relationship between four key elements of quality management: teamwork, feedback, motivational barriers, and need analysis, and their contribution to improve innovativeness in the Colombian educational context. Drawing on the concepts of control and learning in the quality management theory and using publicly available responses collected from the Colombian teachers who participated in the TALIS 2018 survey, this research study examines how teachers perceive these elements within their institutions and their potential impact on fostering innovativeness among teachers. The study adopts an empirical approach to analyze these relationships, employing a descriptive and inferential statistical framework to uncover patterns and correlations. By focusing on the school practices in Colombia, the research seeks to provide insights into how quality management practices can drive innovation in educational settings. Findings identify specific patterns in the implementation of these practices and their relationship with innovativeness among teachers, offering actionable recommendations for improving teaching strategies in education to improve quality. This study contributes to the broader understanding of management’s role in teaching and learning, offering valuable implications for policymakers and practitioners in developing countries. The novelty of this work lies in its analyses of TALIS data to assess quality management practices and their direct influence on fostering innovation.
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