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The Busidima Formation in the Afar region, Ethiopia, spans the Quaternary and records the cultural evolution of the genus Homo. Yet, the Middle Pleistocene to Holocene fluvial environments in which early humans lived are undersampled in eastern Africa. This paper examines the stratigraphy, geochronology and paleoenvironments of the newly designated Odele Member of the uppermost Busidima Formation (<152 thousand years ago (ka)), which has received little attention despite representing a critical period in the evolution of early Homo sapiens and its migration out of Africa. The Odele Member is 40–50 m thick and is dated using tephrochronology, radiometric, luminescence, and electron spin resonance techniques. The member spans 151 to 7 ka, defined at the base by the widespread Waidedo Vitric Tuff (WAVT, 151 ± 16 ka modeled age and 95.4% credible interval - C.I.). There are two prominent erosional unconformities in the Odele Member, a lower one after the WAVT deposition with a modeled 95.4% C.I. range of 124–97 ka; and an upper one involving widespread alluvial fan incision commencing between 21.7 and 12.9 ka. The uppermost Odele Member also contains black, organic-rich mats, redox features, reed casts, and freshwater gastropods marking wetter conditions during the terminal Pleistocene and Early Holocene. A black, fine-grained relict soil coeval with the Halalalee paleosol bounds the top of the Odele Member and has mollic and vertic properties, weathering since ∼12 ka. These incision events and prominent paleosol development near/at the top of the Busidima Formation document Middle to Late Pleistocene Awash River incision to its present-day course. Paleo-rainfall estimates suggest that the Early Holocene-age Halalalee paleosol weathered under a climate with mean annual rainfall 10–15% higher than today. A compilation of radiocarbon ages from aquatic gastropods, carbonized wood and charcoal from the upper Odele Member shows wetter and possibly more vegetated conditions during late marine isotope stage (MIS) 3 and the African Humid Period (AHP) that are tightly coupled with precession-driven summer insolation maxima. These key findings suggest that periods of incision, aggregation, and landscape stability in the Odele Member have an orbital precession pacing. The Odele Member revises upward the age of the Busidima Formation to 7 ka, showing that it spans into the Holocene and now includes Middle and Later Stone Age archaeological traditions.

High-Throughput DNA and RNA sequencing are revolutionizing precision oncology, enabling personalized therapies such as cancer vaccines designed to target tumor-specific neoepitopes generated by somatic mutations expressed in cancer cells. Identification of these neoepitopes from next-generation sequencing data of clinical samples remains challenging and requires the use of complex bioinformatics pipelines. In this paper, we present GeNeo, a bioinformatics toolbox for genomics-guided neoepitope prediction. GeNeo includes a comprehensive set of tools for somatic variant calling and filtering, variant validation, and neoepitope prediction and filtering. For ease of use, GeNeo tools can be accessed via web-based interfaces deployed on a Galaxy portal publicly accessible at https://neo.engr.uconn.edu/. A virtual machine image for running GeNeo locally is also available to academic users upon request. © Copyright 2023, Mary Ann Liebert, Inc., publishers 2023.

Whalebacks, roche moutonnées, and S-forms carved on Ediacaran granitoids near Cerro de las Cuentas, Uruguay, along with overlying diamictites, siltstones, and sandstones displaying soft-sediment grooved and striated surfaces in the Pennsylvanian San Gregorio Formation, record the glacial to post-glacial transition in the linked Norte, southern Paraná and Chaco-Paraná basins of Uruguay, Brazil, and Argentina respectively. Early authors reported these features resulted from subglacial abrasion and deposition as lodgement tills and glaciotectonites. Our re-examination reveals a nuanced setting with changing ice thicknesses, subglacial kinematics, and ice proximal glaciomarine dynamics associated with advance and retreat of an ice stream, or multiple advances of the Uruguayan Ice lobe, during glaciation of the Late Paleozoic Ice Age (LPIA) in these basins. The preserved landforms indicate temperate glacial conditions. Whalebacks formed under 1.6 to 2.5 km-thick ice and likely formed when the lobe extended across the Uruguayan and Rio Grande do Sul shields into the adjacent Paraná Basin. Previously unidentified m-scale roches moutonnées cut into one whaleback developed under thinner ice where reduced basal pressure allowed for the opening of air and water-filled cavities, thus facilitating quarrying on the lee side of basement bumps. S-forms provide additional evidence for the occurrence of subglacial waters, indicating that the basal ice was at or above its pressure melting point. The lower meter of the overlying strata consists of interstratified trace fossil-bearing, laminated siltstones; thin-bedded diamictites; and current-rippled sandstones. Trace fossils belonging to the Mermia ichnofacies within the basal siltstones, as well as acritarchs in the overlying siltstones, suggest that these sediments were deposited in ice-proximal subaqueous settings with contributions from meltwater discharge. Graded siltstone laminae suggest settling from suspension likely from meltwater plumes, while thin-bedded diamictites were deposited either as debris flows or as two-component sedimentation with fines settling from suspension and coarser particles introduce as iceberg-rafted dropstones. Current-rippled sandstones indicate the occurrence of underflow currents. Soft-sediment troughs, grooves, and striations cutting these sediments display curved and sinuous paths with some features oriented perpendicular, and one oriented opposite to the overall trend. They contain marginal and terminal berms typical of iceberg scour marks suggesting transit across the area by icebergs calving from a tidewater ice front located to the SE.

Geography has engaged in insightful discussions on how to understand, analyze, criticize, and implement the blue economy. United Nations agencies, Small Island Developing States, and increased academic interest in oceans have played important roles in the global adoption of the blue economy idea, that is, the sustainable exploitation of marine and coastal resources. Geographical research on the blue economy has addressed key themes such as economic and political discourse, relational thinking and assemblage, sustainability and just transitions, and blue economy risks.

This pilot study explored the use of standardized patients in the virtual classroom in efforts to increase family nurse practitioner preparedness to engage in telemedicine care delivery. Using a mixed-methods approach, we determined this innovation significantly increased students' confidence in their ability to perform a telemedicine visit while also improving their satisfaction with the virtual classroom.

Nearly eight million American youth between the ages of 3 - 17 live with a psychiatric or behavioral health disorder. Many in grades K-12 are being unfavorably impacted in the classroom because of socioeconomic and environmental factors that include poverty, addiction, incarceration, trauma, domesti...

This article focuses on the complex interaction between trade and the environment. The first section reviews the debate among scholars on the environmental effects of trade. Next the article examines the role of the World Trade Organization and how its decisions have impacted the environment. This is followed by a discussion of climate change and its connection to trade. Finally, the article examines multilateral efforts to govern trade and control its environmental consequences as well as to encourage sustainable development. © 2022 Elsevier Inc. All rights reserved.

This study presents an original model that features the emotion of fear of COVID-19 as a direct effect on vaccination intentions. A central research question addressed in the study is what roles do the emotion of fear of contracting COVID-19 and the threat posed by uptake of the COVID-19 vaccination play in levels of vaccination intention? The study used a structural equation model (SEM) and applied the SmartPLS 3.2.6 data analysis tool for model estimation and multivariate analysis variables. A key finding is that vaccination resistance is strongest when fear of COVID-19 is lower, and vaccination threat higher. Vaccination threat appraisal and vaccination intention were found to have a negative relationship. Response costs at higher levels lessen motivation for COVID-19 vaccination. Research implications include research-based targeting of differing segments by their primary fear, either fear of COVID-19 or of the preventative vaccine.

The use of Critical Race Theory, Photovoice, and Community-Based Participatory Research has helped uncover the root causes of issues such as systemic racism in the fields of public health and health promotion. Often, we see studies using traditional research methods to investigate potential causal factors of disparities in minoritized communities report only quantitative data. While these data are imperative for understanding the severity of disparities, quantitative-only approaches cannot address nor can they improve the critical root causes of these disparities. As a team of BIPOC graduate students in public health, we conducted a community-based participatory research project using Photovoice methodology to explore inequities in Black and Brown communities exacerbated during the COVID-19 pandemic. The participatory nature of this research revealed cumulative challenges across the social determinants of health in New Haven and Bridgeport, Connecticut. It allowed us to engage in local-level advocacy to promote health equity as our findings illuminated the need for community-led and community-engaged action. Health and racial inequities cannot be effectively addressed if public health research and programming do not collaborate with the community to build community capacity, empowerment, and trust. We describe our experiences doing community-based participatory research to investigate inequities and provide reflections on their value for public health students. As responses to health inequities and disparities become more politically polarized in the United States, it is critical for public health and health education students to use research methodologies that elevate communities that have been historically marginalized and neglected. Together, we can catalyze equitable change.

We introduce the notion of residual intersections of modules and prove their existence. We show that projective dimension one modules have Cohen-Macaulay residual intersections, namely they satisfy the relevant Artin-Nagata property. We then establish a formula for the core of orientable modules satisfying certain homological conditions, extending previous results of Corso, Polini, and Ulrich on the core of projective one modules. Finally, we provide examples of classes of modules that satisfy our assumptions.

An examination of the lessons learned from William James’s oration on the dedication of the Civil War Monument memorialization Colonel Robert Shaw and the Fifty-Fourth Regiment Massachusetts Infantry, an all-Black unit. The role of monuments in making visible the values of a society is explored in the context of promoting a nation’s historical narrative, in particular in their propagation of the South’s Lost Cause narrative. The genocidal violence against Armenians in the Caucasus by the Azerbaijani regime serves as the second illustration of the abuse of historical narratives. © 2022 Central European Pragmatist Forum. All rights reserved.

With the increasing use of AI in marketing, ethical repercussions are beginning to emerge. From privacy issues, through discrimination of marginalized groups, to emergent systemic social distortions, AI is changing the marketing ethical landscape. In this paper we conduct a structured literature review of the emerging ethical issues posed by AI in the domains of marketing and consumer behavior. We identify three clusters of ethical issues (algorithm, society and existential) and map these to the marketing domains of systems, brands, and consumers. We conclude that the field of ethical marketing AI is still very much in its infancy, but such is the rate of development ethical marketing AI is likely to become an important field for academics and practitioners alike. © 2023 IEEE Computer Society. All rights reserved.

Background. Food insecurity, affecting approximately 10% of the U.S. population, with up to 40% or higher in some communities, is associated with higher rates of chronic conditions and inversely associated with diet quality. Nutrition interventions implemented at food pantries are an effective strategy to increase healthy food choices and improve health outcomes for people experiencing food and nutrition insecurity. Supporting Wellness at Pantries (SWAP), a stoplight nutrition ranking system, can facilitate healthy food procurement and distribution at pantries. Purpose. Guided by the RE-AIM Framework, this study assesses the implementation and outcomes of SWAP as nutritional guidance and institutional policy intervention, to increase procurement and distribution of healthy foods in pantries. Method. Mixed-methods evaluation included observations, process forms, and in-depth interviews. Food inventory assessments were conducted at baseline and 2-year follow-up. Results. Two large pantries in New Haven, Connecticut, collectively reaching more than 12,200 individuals yearly, implemented SWAP in 2019. Implementation was consistent prepandemic at both pantries. Due to COVID-mandated distribution changes, pantries adapted SWAP implementation during the pandemic while still maintaining the ?spirit of SWAP.? One pantry increased the percentage of Green foods offered. Challenges to healthy food distribution are considered. Discussion. This study has implications for policy, systems, and environmental changes. It shows the potential for SWAP adoption at pantries, which can serve as a guide for continued healthy food procurement and advocacy. Maintaining the ?spirit of SWAP? shows promising results for food pantries looking to implement nutrition interventions when standard practice may not be possible.

This investigation assessed the effect of side-lying position on infant oropharyngeal swallow physiology. Infant modified barium swallow studies (MBS) recordings were retrospectively examined in matched-pairs comparing at-risk infants swallowing in both an upright/cradled position and a side-lying position. Swallow parameters were measured independently and through a consensus coding approach. Infants fed in side-lying position showed a decrease in airway invasion severity as compared with when those same infants were fed in an upright/cradled position (P = .009). Bolus location at the time of swallow initiation was higher when infants were fed in side-lying position as compared with cradle position (P = .024), representing decreased risk of airway invasion. Infants fed in side-lying position demonstrated fewer swallows per breaths (P = .032). This pilot study validates the need for additional research to further define the mechanisms related to this improvement, and to determine how diagnosis and medical stability moderate these findings.

This paper analyzes the concept of think tanks and concludes that think tanks have three basic characteristics. Firstly, they are based on academic research, relatively independent operation, and aim to serve scientific decision-making. Taking Ivy League think tanks as an example, this paper provides a preliminary discussion of ways for think tanks to maintain the scientific nature of their research, maintain the independence of their operations, and disseminate research results to enhance their influence. It covers institutional mission, research team construction, institutional governance, fundraising, achievements and activities, and alumni networks. This paper proposes a framework of university think tank generation paths associated with the essential characteristics of think tanks. The paper points out that, as a research consulting organization grown out of universities, university think tanks must maintain the scientific nature and independence of research while providing support and services for decision-making. Only in this way can they truly serve scientific and democratic decision-making, gain the trust of the public and have a real lasting influence.

Several proposals for moral enhancement would use AI to augment (auxiliary enhancement) or even supplant (exhaustive enhancement) human moral reasoning or judgment. Exhaustive enhancement proposals conceive AI as some self-contained oracle whose superiority to our own moral abilities is manifest in its ability to reliably deliver the ‘right’ answers to all our moral problems. We think this is a mistaken way to frame the project, as it presumes that we already know many things that we are still in the process of working out, and reflecting on this fact reveals challenges even for auxiliary proposals that eschew the oracular approach. We argue there is nonetheless a substantial role that ‘AI mentors’ could play in our moral education and training. Expanding on the idea of an AI Socratic Interlocutor, we propose a modular system of multiple AI interlocutors with their own distinct points of view reflecting their training in a diversity of concrete wisdom traditions. This approach minimizes any risk of moral disengagement, while the existence of multiple modules from a diversity of traditions ensures pluralism is preserved. We conclude with reflections on how all this relates to the broader notion of moral transcendence implicated in the project of AI moral enhancement, contending it is precisely the whole concrete socio-technical system of moral engagement that we need to model if we are to pursue moral enhancement.

There is still a lack of reliable intraoperative tools for glioma diagnosis and to guide the maximal safe resection of glioma. We report continuing work on the optical biopsy method to detect glioma grades and assess glioma boundaries intraoperatively using the VRR-LRRTM Raman analyzer, which is based on the visible resonance Raman spectroscopy (VRR) technique. A total of 2220 VRR spectra were collected during surgeries from 63 unprocessed fresh glioma tissues using the VRR-LRRTM Raman analyzer. After the VRR spectral analysis, we found differences in the native molecules in the fingerprint region and in the high-wavenumber region, and differences between normal (control) and different grades of glioma tissues. A principal component analysis–support vector machine (PCA-SVM) machine learning method was used to distinguish glioma tissues from normal tissues and different glioma grades. The accuracy in identifying glioma from normal tissue was over 80%, compared with the gold standard of histopathology reports of glioma. The VRR-LRRTM Raman analyzer may be a new label-free, real-time optical molecular pathology tool aiding in the intraoperative detection of glioma and identification of tumor boundaries, thus helping to guide maximal safe glioma removal and adjacent healthy tissue preservation.

Libraries are adapting to the changing times by providing mobile services. One hundred fifty-one libraries were chosen based on circulation, with at least one library or library system from each state, to explore the diverse services provided to mobile users across the United States. According to the data, mobile apps, mobile reference services, mobile library catalogs, and mobile printing are among public libraries’ most-frequently offered services, as determined by mobile visits, content analysis, and librarian survey responses. Every library examined had at least one mobile website, mobile catalog, mobile app, or webpage adapted for a mobile device. Following the COVID-19 outbreak, services such as mobile renewal, subscriber database access, mobile reservations, and the ability to interact with a librarian were expanded to allow better communication with customers—all from the comfort and safety of their own homes. Libraries are continually looking for innovative methods to assist their mobile customers as the world changes.