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Distinguishing chromophobe renal cell carcinoma (chRCC) from oncocytoma on hematoxylin and eosin images may be difficult and require time-consuming ancillary procedures. Multiphoton microscopy (MPM), an optical imaging modality, was used to rapidly generate sub-cellular histological resolution images from formalin-fixed unstained tissue sections from chRCC and oncocytoma. Tissues were excited using 780nm wavelength and emission signals (including second harmonic generation and autofluorescence) were collected in different channels between 390 nm and 650 nm. Granular structure in the cell cytoplasm was observed in both chRCC and oncocytoma. Quantitative morphometric analysis was conducted to distinguish chRCC and oncocytoma. To perform the analysis, cytoplasm and granules in tumor cells were segmented from the images. Their area and fluorescence intensity were found in different channels. Multiple features were measured to quantify the morphological and fluorescence properties. Linear support vector machine (SVM) was used for classification. Re-substitution validation, cross validation and receiver operating characteristic (ROC) curve were implemented to evaluate the efficacy of the SVM classifier. A wrapper feature algorithm was used to select the optimal features which provided the best predictive performance in separating the two tissue types (classes). Statistical measures such as sensitivity, specificity, accuracy and area under curve (AUC) of ROC were calculated to evaluate the efficacy of the classification. Over 80% accuracy was achieved as the predictive performance. This method, if validated on a larger and more diverse sample set, may serve as an automated rapid diagnostic tool to differentiate between chRCC and oncocytoma. An advantage of such automated methods are that they are free from investigator bias and variability. Copyright © 2016 SPIE.

This article describes the development process for creating a digital educational mini game prototype designed to provide practice opportunities for learning fundamental principles of arterial blood gases. Mini games generally take less than an hour to play and focus on specific subject matter. An interdisciplinary team of faculty from two universities mentored student game developers to design a digital educational mini game prototype. Sixteen accelerated bachelor of science in nursing students collaborated with game development students and playtested the game prototype during the last semester of their senior year in nursing school. Playtesting is a form of feedback that supports an iterative design process that is critical to game development. A 10-question survey was coupled with group discussions addressing five broad themes of an archetypical digital educational mini game to yield feedback on game design, play, and content. Four rounds of playtesting and incorporating feedback supported the iterative process. Accelerated bachelor of science in nursing student playtester feedback suggests that the digital educational mini game prototype has potential for offering an engaging, playful game experience that will support securing the fundamental principles of arterial blood gases. Next steps are to test the digital educational mini game for teaching and learning effectiveness. (C) 2016 Elsevier Inc. All rights reserved.

Error disclosure and apology are evolving concerns for advanced practice nurses who have increased exposure to liability. Error disclosure is required by regulatory agencies and the American Nurses Association Code of Ethics for Nurses, yet barriers to disclosure exist and nurse practitioners may not be aware of state apology laws that protect some statements from use in civil lawsuits for negligence or malpractice. Two law cases that apply apology laws are reviewed to illustrate these protections. Best practices for error disclosure are presented, and nurse educators are urged to include error disclosure content in nurse practitioner curricula as part of safety and quality education.

Health disparities, especially among minorities, persist; obesity is a national concern; and the combined effect can be significant for families and populations. In an effort to address obesity at an early age, the National Association of Hispanic Nurses (NAHN), developed the Muevete USA project. Muevete USA (from the Spanish verb for to move) features five lesson plans on healthy lifestyles for children and their families. This article describes Muevete USA, the partnership with a local school of nursing, the implementation of the program at the local level and the emerging program and student outcomes of a successful partnership.

The shortage of school nurses, school nurses covering multiple buildings, and the expanded role of the school nurse has called for innovative ideas to meet the growing health care needs of youth. Partnering with local schools of nursing may be a welcomed strategy. This brief article will share the benefits of hosting student nurses as well as identify ways to begin these partnerships. © 2016 The Author(s).

This study identified the types of caregiver stress and the caregiver and care management characteristics that are associated with this stress. 169 caregivers were recruited from a variety of community settings that cater to caregivers in a New England metropolitan area. They completed the Zarit Burden Interview (ZBI) and a questionnaire concerning their care recipient and caregiving arrangements. Principal Components Analysis on the ZBI resulted in five factors: personal strain/loss, uncertainty/inadequacy, social strain/embarrassment, anger, and dependency. The average age of the caregiver was 59.95 years (SD = 11.75) and the average age of the CR was 83.44 years (SD = 7.88). Of the 169 caregivers, 82% were women, 61.5% daughters/in-law or wives (12.9%), 34.3% were solo caregivers; 16.8% little or no burden, 39.9% reported mild to moderate burden, 35% moderate to severe burden, and 8.4% had severe burden. Dependency (22.4%) and personal strain/loss (13.7%) had the highest proportions reported as “often” to “nearly always.” The ZBI was predicted by only two caregiver characteristics, indicating that it is not sensitive to the experiences of different types of caregivers. Caregivers experience different types of burden depending on their gender, kinship roles, and levels of involvement in the care of their older relative. Solo caregiver status and age (younger) significantly predicted most if not all 5 burden types. Solo and young caregivers experienced the highest levels of caregiver burden. Social work practice must identify the caregiver’s life stage and other and self-expectations in relation to dependency, personal loss, embarrassment, anger, or uncertainty. © 2016 Taylor & Francis.

To ensure the function of wireless sensor networks (WSNs), nodes that fail to forward packets must be localized efficiently and then fixed or replaced promptly. The state-of-the-art work frames lossy node localization in WSNs as an optimal sequential testing problem guided by end-to-end data. It combines both the active and passive measurements to minimize the testing cost and the number of iterations. However, this hybrid approach has many limitations. Inspired by the success of coverage-based software debugging, and the similarity between software debugging and lossy node localization, we propose a coverage-based lossy node detection for WSNs. Supported by established statistic theories, this approach greatly boosts the performance. Experiments on randomly generated networks and deployed networks show that the proposed algorithm can significantly reduce testing cost and number of iterations, which are the two optimization goals of previous work. We expect to use this approach for other diagnostic problems in WSNs. © 2001-2012 IEEE.

Triangulations of 3-dimensional polyhedron are partitions of the polyhedron with tetrahedra in a face-to-face fashion without introducing new vertices. Schönhardt (Math. Ann. 89:309–312, 1927), Bagemihl (Amer. Math. Mon. 55:411–413, 1948), Kuperberg (Personal communication 2011) and others constructed special polyhedra in such a way that clever one line geometric reasons imply nontriangulability. Rambau (Comb. Comput. Geom. 52:501–516, 2005) proved that twisted prisms over n-gons are nontriangulable. Our approach for proving polyhedra are nontriangulable is to show that partitions with tetrahedra, which we call tilings, do not exist even if the face-to-face-restriction is relaxed. First we construct a polyhedron which is tileable but is not triangulable. Then we revisit Rambau type twisted prisms. In fact we consider a slightly different class of polyhedra, and prove that these new twisted prisms are nontileable, thus are nontriangulable. We also show that one can twist the regular dodecahedron so that it becomes nontileable, which is abstracted to a new family of nontileable polyhedra, called nonconvex twisted pentaprisms. © 2015, The Managing Editors.

We study transformations of finite modules over Noetherian local rings that attach to a module M a graded module H(x)(M) defined via partial systems of parameters x of M. Despite the generality of the process, which are called j-transforms, in numerous cases they have interesting cohomological properties. We focus on deriving the Hilbert functions of j-transforms and studying the significance of the vanishing of some of its coefficients. Copyright © 2016 Cambridge Philosophical Society.

Motor vehicle accidents (MVA) are often difficult to distinguish from non-accidental injury (NAI). This retrospective case–control study compared animals with known MVA trauma against those with known NAI. Medical records of 426 dogs and cats treated after MVA and 50 after NAI were evaluated. Injuries significantly associated with MVA were pelvic fractures, pneumothorax, pulmonary contusion, abrasions, and degloving wounds. Injuries associated with NAI were fractures of the skull, teeth, vertebrae, and ribs, scleral hemorrhage, damage to claws, and evidence of older fractures. Odds ratios are reported for these injuries. MVA rib fractures were found to occur in clusters on one side of the body, with cranial ribs more likely to fracture, while NAI rib fractures were found to occur bilaterally with no cranial–caudal pattern. Establishing evidence-based patterns of injury may help clinicians differentiate causes of trauma and may aid in the documentation and prosecution of animal abuse. © 2016 American Academy of Forensic Sciences

We extend and unify most known results about guarding orthogonal polygons by introducing the same-sign diagonal graphs of a convex quadrangulation and applying results about vertex covers for graphs. Our approach also yields new theorems and often guarantees two disjoint vertex guard sets of relatively small cardinality. For instance, an orthogonal polygon on n vertices has two disjoint vertex guard sets of cardinality at most (Formula presented.). We give new proofs of Aggarwal’s one-hole theorem and the orthogonal fortress theorem. We prove that an orthogonal polygon with n vertices and any number of holes can be protected by at most (Formula presented.) vertex guards, improving the best known bound of (Formula presented.). Also, an orthogonal polygon with n vertices and h holes can be protected by (Formula presented.) guarded guards, which is best possible when (Formula presented.). Moreover, for orthogonal fortresses with n vertices, (Formula presented.) guarded guards are always sufficient and sometimes necessary. © 2016, Springer Science+Business Media New York (outside the USA).

Let P be an orthogonal polygon with n vertices, and let V⁎ and E⁎ be specified sets of vertices and edges of P. We prove that P has a guard set of cardinality at most ⌊(n+3|V⁎|+2|E⁎|)/4⌋ that includes each vertex in V⁎ and at least one point of each edge in E⁎. Our bound is sharp and reduces to the orthogonal art gallery theorem of Kahn, Klawe and Kleitman when V⁎ and E⁎ are empty. © 2016 Elsevier B.V.

Software components, which are vulnerable to being exploited, need to be identified and patched. Employing any prevention techniques designed for the purpose of detecting vulnerable software components in early stages can reduce the expenses associated with the software testing process significantly and thus help building a more reliable and robust software system. Although previous studies have demonstrated the effectiveness of adapting prediction techniques in vulnerability detection, the feasibility of those techniques is limited mainly because of insufficient training data sets. This paper proposes a prediction technique targeting at early identification of potentially vulnerable software components. In the proposed scheme, the potentially vulnerable components are viewed as mislabeled data that may contain true but not yet observed vulnerabilities. The proposed hybrid technique combines the supports vector machine algorithm and ensemble learning strategy to better identify potential vulnerable components. The proposed vulnerability detection scheme is evaluated using some Java Android applications. The results demonstrated that the proposed hybrid technique could identify potentially vulnerable classes with high precision and relatively acceptable accuracy and recall.

Identity is recognized as a powerful antecedent of behavior. Social identity denotes the incorporation of culture into a person’s self-concept. A strong correspondence exists between identity with a given social unit and commitment to group values/norms, and thus, how much influence the social unit exerts on the person’s attitudes and behaviors. As a psychological construct, social identity research requires probing how individuals subjectively interpret their own affiliation with one or several collectivities. Cultures are increasingly emancipated from geography in the global era. Because contemporary consumers are continuously exposed to a variety of cultural influences, they may develop polycentric identities. As companies and markets integrate, a key international market segmentation topic relates to consumers’ mindsets about home and extraneous countries/cultures, and subsequently, the products connected with these entities. To date, no research has simultaneously examined the interrelationships of consumer ethnocentrism (bias towards products from one’s national culture), consumer xenocentrism (i.e., preference or orientation towards products from a culture other than one’s own), and cosmopolitanism (i.e., a yearning for and adeptness at mastering cultural diversity) in a single study. Employing an online survey, and drawing from a representative sample (n = 269) of American consumers drawn from all 50 states (plus D.C.), this research also examines the correspondence of these identity-relevant constructs within a nomological net of pertinent concepts (all of which are established in the marketing literature): materialism, consciousness-of-kind, external orientation (cultural open-mindedness and consumption of foreign media), global consumption orientation, and natural environment concern. The survey contained a total of 60 scales corresponding to the 8 constructs, along with a series of key demographic measures. Exploratory and confirmatory factor analyses were applied to the construct measures. Various analytical techniques were employed (tests for convergent/discriminant validity, bivariate correlations, t-tests, MANOVA, two-step clustering, as well as path analyses using structural equation modelling) to test the 19 proposed theoretical hypotheses. Most hypotheses were supported, in terms of statistical significance and magnitude, as well as directional valence. Associative network memory theory and signaling theory implicate how consumers decide from a constellation of local, foreign, and global product options. Upon activation of a brand node by way of retrieval cues (product categories, brand names, and so forth), linkages such product attributes and semantic associations (e.g., ingroups/outgroups and corresponding levels of felt identification) become salient. Firms can manipulate signals, including associations towards or away from countries/cultures, to position products and persuade consumers. Vertical segmentation, the conventional approach to adapting marketing strategies, entails developing marketing mixes for each country, from the near limitless combination of demographic, economic and psychographic variables. Due to the globalization of media and the widespread movement of products and peoples across borders a growing number of researchers instead advocate horizontal segmentation, whereby similar groups of consumers are targeted with an essentially uniform marketing strategy, irrespective of where they might live. Individuals’ inward and outward dispositions—towards their own and different countries, cultures, and products—are sound candidate constructs for designing horizontal strategies.

Purpose - A first objective is to add insight into how constructs of ethnocentrism, xenocentrism and cosmopolitanism relate to each other. Knowledge of how these constructs overlap or work together in affecting consumer preferences will offer global marketers insights for designing appropriate marketing strategies. The second objective is to extend this knowledge by examining the correspondence of these three constructs to a nomological network of dispositional concepts pertinent for product positioning and market segmentation. The third objective is to empirically examine the extent to which the measures, construct structure and associative relationships are robust in different national research settings. The paper aims to discuss these issues. Design/methodology/approach - Surveying British and American consumers, this study examines and analyzes the correspondence of these identity-relevant constructs within a nomological net of pertinent concepts: consciousness-of-kind, global consumption orientation, materialism and natural environment concern. Findings - The hypothesized negative links between CET-XEN and CET-COS, and the predicted positive connection between XEN-COS were all confirmed on the latent factor results for the combined data set. The negative correlation between CET-XEN was of a considerably lower magnitude than that for CET-COS. Originality/value - To date, no research has used an identity theory framework and simultaneously examined in a cross-cultural context the interrelationships of consumer ethnocentrism consumer xenocentrism and cosmopolitanism - and their differentiating linkages to a multiplicity of consumer dispositions.

Purpose: Problems of relationship quality and interfirm conflict in business-to-business settings are serious concerns that need to be addressed. Thus, the authors have engaged in an extensive review to promote an understanding of these complex issues. This article develops an integrated framework for analyzing wide-ranging relations between individual representatives and patterns of interfirm incompatibility for managerial control.Methodology/approach: The review involves numerous sources that include articles and monographs. A theoretical framework is constructed to integrate fragmented empirical data. In particular, social identity and commitment-trust theories are mobilized for this framework.Findings: The review of studies has a substantial consistency with the theoretical framework. The article outlines a causal chain from interpersonal agent dissimilarities to dysfunctional buyer-supplier relations, culminating in interfirm pathological conflict. Moderating factors in the causal chain are: agent identity differentiation (for interpersonal dissimilarity), supplier relations mismanagement (for buyer-supplier relationship quality), and interfirm opportunism (for interfirm pathological conflict). Buyer-supplier interfirm incompatibility mediates the causal link between interpersonal dissimilarity and buyer-supplier relationship quality. Identity differentiation, the validation of one's self-image, is introduced as a process that determines buyer-supplier agent interpersonal dissimilarity judgments. This framework uses a contextual perspective. It describes interactions between observations of micro-level phenomena of interpersonal dissimilarities and macro-level models of interfirm fit. From a managerial perspective, interpersonal relations between individual buyer and supplier agents may be further strengthened by such strategies as expanding the scope of the interpersonal relationship, relaxation of role responsibilities, and volunteering business-related contact referrals.Originality/value: A new theoretical framework has been devised to predict and explain relationship quality and interfirm pathological conflict in the business-to-business context. The framework contributes to the value of the knowledge base by serving as a means for building new diagnostic tools for assessment of interfirm behavioral issues affecting exchanges. New concepts are introduced to enhance current literature on business-to-business marketing. The framework provides concreteindicators that operationally define ideas and enable or improve measurement for empirical modeling.

Six women faculty came together to research their peers asking other women in COAMFTE-accredited programs about their personal and professional identities. The goal of this research was to develop recommendations for the field of Couple/Marriage and Family Therapy to support the engagement and advancement of women faculty. The research collaboration itself became a heuristic, feminist praxis, a co-creation of insight, support network, and professional relationships which had liberating results for the collaborators. We intended to create a research project that would be collaborative, empowering, and transformative for participants; in the process, the collaboration became empowering and transformative for ourselves. This article will reflect on our experiences and provide recommendations for future feminist research teams. Copyright © Taylor & Francis Group, LLC.