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The effect of vasopressin on memory of a brightness discrimination reward task was investigated in 20 male Sprague-Dawley rats. Two measures of retention were used: resistance to extinction and savings scores on a reacquisition task given 45 days after the completion of extinction training. The effect of the peptide on both memory consolidation and retrieval was assessed. There were two major findings: (a) The peptide enhanced memory consolidation of the task whether measured after a short time interval (6 days) or after a long time interval (45 days after completion of extinction training) using a measure of trials to relearn the task, and (b) the peptide had no effect on memory retrieval. These results were compared to those of other studies designed to access memory consolidation and retrieval on appetitive tasks. The mechanisms of the peptide's effect on memory was briefly discussed with respect to three theories on the subject. This study extends the vasopressin research on memory consolidation by suggesting that it pertains to appetitive as well as to aversive tasks.
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The study compared 71 patients diagnosed as schizophrenic or within the schizophrenia spectrum according to the second edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-II) with 66 patients who received similar diagnoses according to the third edition of the same manual (DSM-III). On measures of premorbid competence and role orientation, DSM-II and DSM-III schizophrenic patients obtained comparable scores. The DSM-III patients with schizophrenic versus schizophrenia spectrum diagnoses also obtained comparable scores on these measures. The gender differences in premorbid competence and role orientation that have consistently characterized DSM-II schizophrenics continued to characterize DSM-III schizophrenic and schizophrenia spectrum patients. The results suggest that findings previously obtained with DSM-II schizophrenics concerning premorbid competence and role orientation can be generalized to DSM-III schizophrenics. © 1987 American Psychological Association.
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The Mini‐Mult and MMPI were administered in random order to 60 blind male veterans admitted to a residential rehabilitation program. Mini‐Mult scores predicted the presence or absence of MMPI pathology in 81.7% of the cases. Correlations between the individual Mini‐Mult and MMPI scales were significant at the p < .01 level, but not of sufficient magnitude to permit their interchangeability or to allow for profile diagnosis on the basis of Mini‐Mult scores. Analysis of the false negatives raises questions about the clinical significance of an abnormal MMPI in the population studied. The results support the value of the Mini‐Mult as a screening device, but not as a substitute for a detailed psychological assessment of the blind. Copyright © 1986 Wiley Periodicals, Inc., A Wiley Company
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The relation between premorbid social competence and outcome was examined in 448 (228 male and 220 female) first-admission, nonschizophrenic, state-hospital patients. For both sexes, higher social competence was related to more favorable outcome as reflected in shorter initial hospitalizations and shorter rehospitalizations. Consistent with a developmental formulation, these results provide further evidence that the relation between premorbid competence and outcome is not unique to schizophrenia but can be found for patients of both sexes across a range of diagnoses. © 1986 American Psychological Association.
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Age at first hospitalization, premorbid social competence, and developmental categorizations of symptomatology were examined in 228 male and 220 female patients in three diagnostic categories: Major affective disorder, neuroses, and personality disorder. High social competence patients were older at first hospitalization than low competence individuals. Younger first admission patients showed more symptoms in the action category and in the role orientation of turning against others. Older patients more frequently displayed symptoms of the thought variety and of turning against the self. Gender differences in age at first hospitalization were not found. With respect to all developmental variables examined, the results suggest that a broader view of prognosis proposed in research with schizophrenic patients is applicable to nonschizophrenic groups. © 1985 by The Williams & Wilkins Co.
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The relation between premorbid social competence and length of initial hospitalization was examined in 381 male state hospital patients in four diagnostic categories: Schizophrenic, affective reaction, psychoneurotic, and personality disorder. A significant relation was discovered between diagnosis and outcome, with schizophrenic patients having the longest and personality disorder patients the shortest lengths of initial hospitalization. Premorbid social competence was related to outcome, as assessed both by length of initial hospitalization, and by whether the patient was rehospitalized. These two outcome measures were found to be positively related, thus supporting the developmental formulation that premorbid social competence is indicative generally of prognosis. The findings were employed to generate the inference that patients at differing levels of premorbid social competence require different treatment modalities. © 1981 by The Williams & Wilkins Co.
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In a diagnostically heterogeneous sample of 381 first admission male state hospital patients, no consistent correlations appeared among three commonly employed hospitalization measures of outcome. The possibility that psychiatric hospitalization may be a multidimensional criterion is considered and the implications for outcome research are discussed. © 1980 by The Williams & Wilkins Co.
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