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BACKGROUND: Despite considerable knowledge that prenatal ethanol exposure can lead to devastating effects on the developing fetus, alcohol consumption by pregnant women remains strikingly prevalent. Both clinical and basic research has suggested that, in addition to possible physical, behavioral, and cognitive deficits, gestational exposure to alcohol may lead to an increased risk for the development of later alcohol-related use and abuse disorders. The current work sought to characterize alterations in endogenous opioid signaling peptides and gene expression produced by ethanol exposure during the last days of gestation., METHODS: Experimental subjects were 4-, 8-, and 12-day old infant rats obtained from pregnant females that were given daily intubations of 0, 1, or 2g/kg ethanol during the last few days of gestation (GDs 17-20). Using real-time RT-PCR, western blotting analysis, and enzyme immunoassays, we examined mRNA and protein for three opioid receptors and ligands in the nucleus accumbens, ventral tegmental area, and hypothalamus., RESULTS: Three main trends emerged - (1) mRNA for the majority of factors was found to upregulate across each of the three postnatal ages assessed, indicative of escalating ontogenetic expression of opioid-related genes; (2) prenatal ethanol significantly reduced many opioid peptides, suggesting a possible mechanism by which prenatal exposure can affect future responsiveness towards ethanol; and (3) the nucleus accumbens emerged as a key site for ethanol-dependent effects, suggesting a potential target for additional assessment and intervention towards understanding the ethanol's ability to program the developing brain., CONCLUSION: We provide a global assessment of relatively long-term changes in both opioid gene expression and protein following exposure to only moderate amounts of ethanol during a relatively short window in the prenatal period. These results suggest that, while continuing to undergo ontogenetic changes, the infant brain is sensitive to prenatal ethanol exposure and that such exposure may lead to relatively long-lasting changes in the endogenous opioid system within the reward circuitry. These data indicate a potential mechanism and target for additional assessments of ethanol's ability to program the brain, affecting later responsiveness towards the drug. Copyright © 2015 Elsevier Inc. All rights reserved.

Rats exhibit a sensitive period from the time of birth until postnatal day 10 during which they develop preferences for odors even if those odors are paired with a moderately aversive stimulus. It is still unknown whether pre-exposure to an odor produces alterations on intake responses of basic tastants, and on other patterns that indicate a change in the hedonic value of reward, such as nipple grasping behavior. The current study assessed the effect of pre-exposure to an odor immediately after birth on intake responses of appetitive and aversive tastants. The objectives were to assess if 3-hour-old rats adjust their behaviors to obtain different values of appetitive and aversive rewards in the presence of a familiar odor. Specifically we wanted to determine whether the intake of saccharin or quinine, administered through the artificial nipple, increases in the presence of the familiar odor. Results showed that 3-hour-old rats differentially respond to two different concentrations of saccharin and two concentrations of quinine. In the presence of the pre-exposed odor newborn rats increased intake and grasp responses to the artificial nipple containing quinine. This effect disappeared with a higher concentration of quinine. These results suggest that the pre-exposed odor generated a change in the hedonic value of the aversive reward. Copyright © 2014 Elsevier Inc. All rights reserved.

Gestational alcohol use is well documented as detrimental to both maternal and fetal health, producing an increase in offspring's tendency for alcoholism, as well as in behavioral and neuropsychological disorders. In both rodents and in humans, parental care can influence the development of offspring physiology and behavior. Animal studies that have investigated gestational alcohol use on parental care and/or their interaction mostly employ heavy alcohol use and single strains. This study aimed at investigating the effects of low gestational ethanol dose on parental behavior and its transgenerational transmission, with comparison between two rat strains. Pregnant Sprague Dawley (SD) and Long Evans (LE) progenitor dams (F0) received 1g/kg ethanol or water through gestational days 17-20 via gavage, or remained untreated in their home cages. At maturity, F1 female offspring were mated with males of the same strain and treatment and were left undisturbed through gestation. Maternal behavior was scored in both generations during the first six postnatal days. Arch-back nursing (ABN) was categorized as: 1, when the dam demonstrated minimal kyphosis; 2, when the dam demonstrated moderate kyphosis; and 3, when the dam displayed maximal kyphosis. Overall, SD showed greater amounts of ABN than LE dams and spent more time in contact with their pups. In the F0 generation, water and ethanol gavage increased ABN1 and contact with pups in SD, behaviors which decreased in treated LE. For ABN2, ethanol-treated SD dams showed more ABN2 than water-treated dams, with no effect of treatment on LE animals. In the F1 generation, prenatal exposure affected retrieval. Transgenerational transmission of LG was observed only in the untreated LE group. Strain-specific differences in maternal behavior were also observed. This study provides evidence that gestational gavage can influence maternal behavior in a strain-specific manner. Our results also suggest that the experimental procedure during gestation and genetic variations between strains may play an important role in the behavioral effects of prenatal manipulations. Copyright © 2015 Elsevier Inc. All rights reserved.

Discrete variation in reproductive behavior and physiology is observed in diverse taxa. Although it is known that most within-sex alternative reproductive tactics arise as a consequence of phenotypic plasticity, relatively little is known about differential neural gene expression among plastic alternative reproductive phenotypes. In the ocellated wrasse Symphodus ocellatus, males exhibit one of three alternative tactics (nesting, satellite, and sneaker) within a reproductive season, but switch tactics between years. Satellites and sneakers spawn parasitically in dominant (nesting) males' nests, but only nesting males provide parental care. Nesting and satellite males show transient cooperative defense of nests against sneakers. Here, we analyze circulating sex steroid hormone levels and neural gene expression profiles in these three male phenotypes and in females. 11-ketotestosterone (but not testosterone) was highest in nesting males, while estradiol was highest in females. Brain transcriptomes of satellites and females were most similar to each other and intermediate to nesting and sneaker males. Sneakers showed more total expression differences, whereas nesting males showed higher magnitude expression differences. Our findings reveal the surprising extent to which neural gene expression patterns vary across reproductive tactics that vary in a number of social traits, including aggression, territoriality, and cooperation, providing important insights into the molecular mechanisms that may underlie variation in cooperative and reproductive behavior. © 2014 Blackwell Verlag GmbH.

Four rats responded on concurrent variable-interval schedules that delivered token stimuli (stimulus lights arranged vertically above each of two side levers). During exchange periods, each token could be exchanged for one food pellet by responding on a center lever, with one response required for each pellet delivery. In different conditions, the exchange requirements (number of tokens that had to be earned before they could be exchanged for food) varied between one and four for the two response levers. The experiments were closely patterned after research with pigeons by Mazur and Biondi (), and the results from the rats in the present experiment were similar. Response percentages on the two levers changed as each additional token was earned, and these patterns indicated that choice was controlled by both the time to the exchange periods and the number of food pellets that were delivered in the exchange period. In some conditions, the exchange requirement was three tokens for each lever, but the token lights were not turned on as they were earned for one of the two keys. The rats showed a slight preference for the lever without the token lights, which may indicate that the token lights were not serving as conditioned reinforcers (a result also found by Mazur and Biondi with pigeons). Overall, these results suggest that, in this choice procedure, the token stimuli served primarily as discriminative stimuli that signaled the temporal proximity and quantity of the primary reinforcer, food.

This correlational study examined the relationships among ego strengths and career identity. Self-report data were collected from a sample of university undergraduates (N = 239). Participants completed the Psychosocial Inventory of Ego Strengths and the Vocational Identity Status Assessment. The results revealed gender differences, primarily in career identity. The findings also showed that the unique variance explained in career identity by each ego strength was modest, indicating that the best predictor of career identity is the overall level of ego strengths. Suggestions for future research, such as longitudinal designs to establish ego strengths as developmental precursors of career identity, are provided. © 2014 Copyright Taylor & Francis Group, LLC.

Agreement on the causes of sexual offending has eluded scholars because of an emphasis on studying proximate causes—as with crime in general, there are numerous variables that correlate with sexual offending. A more consilient view of sexual offending includes an evolutionary approach that attempts to answer ultimately why such behavior exists. To guide this research, Camilleri (The Oxford handbook of evolutionary perspectives on violence, homicide, and war, New York, 173–196) proposed a typology of sexual offenders that classifies offending based on two dimensions: (1) whether the behavior is an adaptation, by-product, or disorder and (2) if the mechanism is obligate or facultative. Categories resulting from this typology seem to capture the variability of sexual offending behavior. This chapter mostly reviews evidence of how sexual offending could function as an adaptation, draws links from nonhuman behavior literature, and briefly reviews alternative explanations, including by-products and disorders.

Background: Approximately 10 to 15% of women consume alcohol (ethanol [EtOH]) during pregnancy in the United States. Even low amounts of EtOH consumption during pregnancy can elicit long-term consequences. Prenatal experience with as few as 3 drinks has been associated with increase problem drinking in adulthood. Such effects are corroborated in rodents; however, the underlying neural adaptations contributing to this effect are not clear. In the current set of experiments, we investigated whether changes in EtOH responding following prenatal EtOH exposure involved kappa opioid receptor activation and expression. Methods: Sprague-Dawley rats were prenatally exposed to low levels of alcohol (1.0 g/kg) during late gestation (gestational days 17 to 20 [GD17-20]) via intragastric intubation of pregnant dams. Following birth, EtOH intake, kappa- and mu-opioid-induced place conditioning, and kappa opioid receptor expression in mesolimbic brain regions were assessed in infant rats (postnatal days 14 to 15 [PD14-15]) that were offspring of dams given EtOH, vehicle, or untreated, during pregnancy. Results: Animals exposed to prenatal alcohol drank more alcohol later in life and exhibited significant changes in the kappa opioid system. While control subjects found kappa opioid activation aversive, animals exposed to EtOH prenatally exhibited either no aversion or appetitive responding. Further analysis revealed that synaptosomal kappa opioid receptor expression was significantly decreased in brain areas implicated in responding to EtOH. Conclusions: Overall, these data suggest that prenatal EtOH affects kappa opioid function and expression and that these changes may be involved in increased drinking later in life. © 2014 by the Research Society on Alcoholism.

By 12months, children grasp that a phonetic change to a word can change its identity (phonological distinctiveness). However, they must also grasp that some phonetic changes do not (phonological constancy). To test development of phonological constancy, sixteen 15-month-olds and sixteen 19-month-olds completed an eye-tracking task that tracked their gaze to named versus unnamed images for familiar words spoken in their native (Australian) and an unfamiliar non-native (Jamaican) regional accent of English. Both groups looked longer at named than unnamed images for Australian pronunciations, but only 19-month-olds did so for Jamaican pronunciations, indicating that phonological constancy emerges by 19months. Vocabulary size predicted 15-month-olds' identifications for the Jamaican pronunciations, suggesting vocabulary growth is a viable predictor for phonological constancy development.

Twelve pigeons responded on concurrent variable-interval schedules that delivered token stimuli (stimulus lights for some pigeons, and white circles on the response keys for others). During exchange periods, each token could be exchanged for food on a fixed-ratio 1 schedule. Across conditions, the exchange requirements ( number of tokens that had to be earned before they could be exchanged for food) varied between one and four for the two response keys. The main findings were that the pigeons' response percentages varied as a function of the number of tokens earned at any given moment, and they were determined by both the delays to food and by the number of food deliveries in the exchange periods. In some conditions, tokens had to be earned but were not visible during the variable-interval schedules for one or both keys. When one key had visible tokens and the other did not, the pigeons showed a preference for the key without visible tokens. A model based on the matching law and a hyperbolic delay-discounting equation could account for the main patterns of choice responding, and for how response percentages changed as successive tokens were earned. The results are consistent with the view that the token stimuli served as discriminative stimuli that signaled the current delays to food.

The present chapter details the historical and conceptual evolution of a new paradigm in statement analysis that has developed over the past 20 years. There has been an increasing awareness of the importance of interviewing designed to facilitate the detection of deception as a necessary component of statement analysis (Colwell, Hiscock, & Memon, 2002; Hartwig & Bond, 2011; Hernández-Fernaud & Alonso-Quecuty, 1997; Koehnken, Schimossek, Ascherman, & Hofer, 1995; Vrij, Fisher, Mann, & Leal, 2006). Subsequently, the work of multiple researchers has created a zeitgeist that has nurtured and informed the development of this new paradigm. This chapter begins by providing a quick overview of the various lines of research that comprise this paradigm. Attention is then given to credibility assessment and statement content criteria that discriminate honest from deceptive responding. Then, the focus is on strategies of impression management and the subjective experience of respondents during an investigative interview. This sets the stage for a discussion of investigative interviewing structure and techniques that facilitate the detection of deception through the process of differential recall enhancement (DRE: Colwell et al., 2012). Finally, this chapter considers in detail an approach to interviewing and assessment that is representative of the new paradigm.

When reproductive competitors tolerate or cooperate with one another, they may gain particular benefits, such as collectively guarding resources or attracting mates. Shared resources may be those essential to reproduction, such as a breeding site or nest. Using the tessellated darter, a species where males but not females compete over potential nest sites, we examined site use and sharing under controlled conditions of differing competitor density. Sharing was observed even when competitor density was low and individuals could have each occupied a potential nest site without same-sex sharing. Males were more likely to share a nest site with one other when the difference in size between them was larger rather than smaller. There was no evidence that female sharing was dependent on their relative size. Fish were generally more likely to use and share larger sites, in accordance with the greater relative surface area they offered. We discuss how one or both sharing males may potentially benefit, and how male sharing of potential nest sites could relate to female mating preferences. Tessellated darter males are known to provide alloparental care for eggs but this occurs without any social contact between the alloparent and the genetic father of the young. Thus, the suggestion that they may also share sites and maintain social contact with reproductive competitors highlights the importance of increased focus on the potential complexity of reproductive systems.

Child neglect is the most prevalent form of child maltreatment in the United States, and poses a serious public health concern. Children who survive such episodes go on to experience long-lasting psychological and behavioral problems, including higher rates of post-traumatic stress disorder symptoms, depression, alcohol and drug abuse, attention-deficit/hyperactivity disorder, and cognitive deficits. To date, most research into the causes of these life-long problems has focused on well-established targets such as stress responsive systems, including the hypothalamus-pituitary-adrenal axis. Using the maternal separation and early weaning model, we have attempted to provide comprehensive molecular profiling of a model of early-life neglect in an organism amenable to genomic manipulation: the mouse. In this article, we report new findings generated with this model using chromatin immunoprecipitation sequencing, diffuse tensor magnetic resonance imaging, and behavioral analyses. We also review the validity of the maternal separation and early weaning model, which reflects behavioral deficits observed in neglected humans including hyperactivity, anxiety, and attentional deficits. Finally, we summarize the molecular characterization of these animals, including RNA profiling and label-free proteomics, which highlight protein translation and myelination as novel pathways of interest.

In the Monty Hall dilemma, an individual chooses between three options, only one of which will deliver a prize. After the initial choice, one of the nonchosen options is revealed as a losing option, and the individual can choose to stay with the original choice or switch to the other remaining option. Previous studies have found that most adults stay with their initial choice, although the chances of winning are 2/3 for switching and 1/3 for staying. Pigeons, college students, and preschool children were given many trials on this task to examine how their choices might change with experience. The college students began to switch on a majority of trials much sooner than the pigeons, contrary to the findings by Herbranson and Schroeder (2010) that pigeons perform better than people on this task. In all three groups, some individuals approximated the optimal strategy of switching on every trial, but most did not. Many of the preschoolers immediately showed a pattern of always switching or always staying and continued this pattern throughout the experiment. In a condition where the probability of winning was 90% after a switch, all college students and all but one pigeon learned to switch on nearly every trial. The results suggest that one main impediment to learning the optimal strategy in the Monty Hall task, even after repeated trials, is the difficulty in discriminating the different reinforcement probabilities for switching versus staying.

The lexical decision (LD) and naming (NAM) tasks are ubiquitous paradigms that employ printed word identification. They are major tools for investigating how factors like morphology, semantic information, lexical neighborhood and others affect identification. Although use of the tasks is widespread, there has been little research into how performance in LD or NAM relates to reading ability, a deficiency that limits the translation of research with these tasks to the understanding of individual differences in reading. The present research was designed to provide a link from LD and NAM to the specific variables that characterize reading ability (e.g., decoding, sight word recognition, fluency, vocabulary, and comprehension) as well as to important reading-related abilities (phonological awareness and rapid naming). We studied 99 adults with a wide range of reading abilities. LD and NAM strongly predicted individual differences in word identification, less strongly predicted vocabulary size and did not predict comprehension. Fluency was predicted but with differences that depended on the way fluency was defined. Finally, although the tasks did not predict individual differences in rapid naming or phonological awareness, the failures nevertheless assisted in understanding the cognitive mechanisms behind these reading-related abilities. The results demonstrate that LD and NAM are important tools for the study of individual differences in reading.

This study examined cognitive-affective styles associated with position on the Iraq war by analyzing responses posted on an online discussion forum using a computerized text-analysis program (Linguistic Inquiry and Word Count). Overall, the results were consistent with those obtained in narrative-coding studies. The pro-war group was associated with an external focus and a simplistic style of information processing. The anti-war group was associated with an internal focus and high levels of cognitive processing and negative emotion words. The “neither” group scored the highest on cognitive complexity and positive emotion words, and it was also the most balanced in terms of internal and external focus.

This study analyzed distributions of Euclidean displacements in gaze (i.e. “gaze steps”) to evaluate the degree of componential cognitive constraints on audio-visual speech perception tasks. Children performing these tasks exhibited distributions of gaze steps that were closest to power-law or lognormal distributions, suggesting a multiplicatively interactive, flexible, self-organizing cognitive system rather than a component-dominant stipulated cognitive structure. Younger children and children diagnosed with an autism spectrum disorder (ASD) exhibited distributions that were closer to power-law than lognormal, indicating a reduced degree of self-organized structure. The relative goodness of lognormal fit was also a significant predictor of ASD, suggesting that this type of analysis may point towards a promising diagnostic tool. These results lend further support to an interaction-dominant framework that casts cognitive processing and development in terms of self-organization instead of fixed components and show that these analytical methods are sensitive to important developmental and neuropsychological differences.

Despite the importance of credibility assessments in forensic settings, research shows that forensic professionals are mediocre at this task. This study tested the efficacy of a 2.5-hour training workshop on Assessment Criteria Indicative of Deception (ACID), a system of investigative interviewing and credibility assessment using verbal content analysis, in a sample of 99 forensic professionals at a maximum-security forensic hospital in the United States. Accuracy in detecting deception was assessed before and after training via written transcripts. Results showed that training improved participants' accuracy, with accuracy rates increasing from 61% to 70%. Implications of the findings and recommendations for future research are discussed.

Background: Adolescent and adult samples have shown that the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) abuse and dependence criteria lie on a continuum of alcohol problem severity, but information on criteria functioning in college students is lacking. Prior factor analyses in a college sample (Beseler et al., 2010) indicated that a 2-factor solution fit the data better than a single-factor solution after a binge drinking criterion was included. The second dimension may indicate a clustering of criteria related to excessive alcohol use in this college sample. Methods: The present study was an analysis of data from an anonymous, online survey of undergraduates (N = 361) that included items pertaining to the DSM-IV alcohol use disorder (AUD) diagnostic criteria and binge drinking. Latent class analysis (LCA) was used to determine whether the criteria best fit a categorical model, with and without a binge drinking criterion. Results: In an LCA including the AUD criteria only, a 3-class solution was the best fit. Binge drinking worsened the fit of the models. The largest class (class 1, n = 217) primarily endorsed tolerance (18.4%); none were alcohol dependent. The middle class (class 2, n = 114) endorsed primarily tolerance (81.6%) and drinking more than intended (74.6%); 34.2% met criteria for dependence. The smallest class (class 3, n = 30) endorsed all criteria with high probabilities (30 to 100%); all met criteria for dependence. Alcohol consumption patterns did not differ significantly between classes 2 and 3. Class 3 was characterized by higher levels on several variables thought to predict risk of alcohol-related problems (e. g., enhancement motives for drinking, impulsivity, and aggression). Conclusions: Two classes of heavy-drinking college students were identified, one of which appeared to be at higher risk than the other. The highest risk group may be less likely to “mature out” of high-risk drinking after college.

The current study examined relationships among online quiz parameters and students' classroom exam scores. The authors analyzed data from undergraduate courses across four semesters. The results revealed that regardless of the different parameters set for the online quizzes, the number of attempts that students made on quizzes was unrelated to their classroom exam scores, yet the amount of time they spent on quizzes was correlated negatively with their classroom exam scores. The results also revealed that students' scores on the online quizzes predicted their classroom exam scores, above and beyond the number of attempts, length of time allowed on quizzes, as well as their SAT Reading and SAT Math scores. The implications of these results are discussed subsequently. Future researchers may wish to provide empirical evidence on how not counting all of students' online quiz scores toward their final grade may influence students' quiz performance, given the anxiety that time limits can foster.