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Research on the composition of the tumor micro-environment has demonstrated that membrane delimited microvesicles are shed from many types of malignant tumors, in the peripheral blood of cancer patients as well as in culture media of tumor cells propagated in vitro (Ginestra et al. Anticancer Res 18:3433-3437, 1998). Their documented effects involve the activation of signal transduction pathways by cellular cross-talk that are associated with epigenetic mechanisms that may be important in tumor progression, metastasis, and the activation of angiogenesis (Distler et al. Arthritis Rheum 52:3337-3348, 2005). Live cell imaging microscopic studies conducted in our laboratory of the formation of solid tumor spheroids in vitro show that the shedding of microvesicular structures from tumor cells occurs during this process. The observed properties of the tumor microvesicles suggest a role in solid tumor formation and intercellular communication. The tumor associated microvesicles were shown to be non-apoptotic based on the absence of fluorescent nuclear staining by acridine orange/ethidium bromide staining. Increased concentration of extracellular Ca(++) [5-20 mM] resulted in an increase in the production of tumor-derived microvesicles and also to result in the formation of tumor spheroids whose size was considerably smaller than controls. Increased extracellular [Ca(++)] was also observed to induce the rapid dissociation of solid tumor spheroids to smaller cell aggregates in the absence of significant apoptosis.

Inter-site technological variation in the archaeological record is one of the richest potential sources of information about Plio-Pleistocene hominid behavior and evolution. However, appropriate methods for describing and comparing Oldowan assemblages have yet to be agreed upon, and interpretation of the early record remains highly controversial. Particularly salient is disagreement over whether the Oldowan is a single technological phenomenon or is more accurately divided into multiple regional and/or chronological traditions, perhaps including a less developed Pre-Oldowan phase in the late Pliocene. Some of this disagreement reflects theoretical and methodological differences between research traditions and some is more directly evidential. Here we present a framework for describing and interpreting Oldowan variation and apply it to three Pliocene assemblages (EG-10, EG-12, and OGS-7) from Gona, all dated to c. 2.6 million years (Ma). Results indicate proficient knapping and a full range of Oldowan reduction strategies in these earliest known occurrences, consistent with the idea of an Oldowan “technological stasis” from 2.6–1.6Ma. Patterns of variation in raw material selection and predominant reduction strategy at each site clearly indicate the importance of cultural transmission in the Oldowan, but confounding ecological and economic variation continue to render interpretation in terms of multiple tool making traditions or species inappropriate. We propose that cultural transmission and ecological adaptation should be recognized as complementary, rather than mutually exclusive, mechanisms in future attempts to explain Oldowan technological variation.

While the four species of horseshoe crabs share many common reproductive traits with respect to their reproductive systems, they do differ with respect to their mating behavior (monogamy vs. polygynandry). Past research has attributed these differences to a number of factors including: spawning densities, operational sex ratios (OSR's), male condition (or age), environmental and/or genetic factors, or a combination thereof. Mating behaviors in the three Asian horseshoe crab species (Tachypleus gigas, T. tridentatus, and Carcinoscorpius rotundicauda) with low spawning densities and 1:1 operational sex ratios are typically monogamous. In Limulus polyphemus, mating behavior is more variable ranging from monogamy to polygynandry. Here we provide evidence, through a long term behavioral study, that variation in mating behavior is influenced by population density in L. polyphemus. Our study population on two beaches in Connecticut (Long Island Sound) have a spawning density 400 times less than that found in Delaware Bay (0.002 females/m2 vs. 0.8 females/m2) but similar operational sex ratios. Between 90%-95% of all spawning females in CT were paired with only one male, thus exhibiting monogamous behavior. In contrast, between 30 and 60% of spawning females in Delaware Bay have more than one mate and produce clutches of eggs with multiple paternities. Male condition played no role in mating behavior in CT populations. We also observed that on average 18% of the females on the spawning beaches are single. These results suggest that population density is an important condition that determines mating behavior. Also, low population density may lead to decreased mate finding ability and lost opportunities for spawning [Current Zoology 56 (5): 634-642, 2010]. © 2010 Current Zoology.

The rhizosphere in terrestrial systems is the region of soil surrounding plant roots where there is increased microbial activity; in aquatic plants, this definition may be less clear because of diffusion of nutrients in water, but there is still a zone of influence by plant roots in this environment [1]. Within that zone chemical conditions differ from those of the surrounding environment as a consequence of a range of processes that were induced either directly by the activity of plant roots or by the activity of rhizosphere microflora. Recently, there are a number of new studies related to rhizospheres of aquatic plants and specifically their increased potential for remediation of contaminants, especially remediation of metals through aquatic plant-microbial interaction. Copyright 2010 Elsevier Ltd. All rights reserved.

The adaptation of traditional, face-to-face courses to the online format presents both challenges and opportunities. Many pedagogical practices need to be rethought when designing online courses. A successful online course needs to be intellectually stimulating and engaging. The chapter demonstrates how to create an engaging learning environment without any additional budget. The author describes approaches that she has developed, experimented with, and found to be effective in asynchronous online art history courses, as well as learner engagement strategies she has implemented in the eLearning environment. Advantages of scenario-based discussions board assignments and the effects of role playing in discussion forums are discussed. The author shares examples of personalized discussion board assignments aimed to motivate online learners, create a collaborative learning environment, improve peer-to-peer interaction, and prevent plagiarism.

"Frans Hals and the Vernacular" published on 01 Jan 2012 by Brill.

"Medieval renaissance Baroque" celebrates Marilyn Aronberg Lavin's breakthrough achievements in both the print and digital realms of art and cultural history. Fifteen friends and colleagues present tributes and essays that reflect every facet of this renowned scholar's brilliant career. Tribute presenters include Ellen Burstyn, Langdon Hammer, Phyllis Lambert, and James Marrow. Contributors include Kirk Alexander, Horst Bredekamp, Nicola Courtright, David Freedberg, Jack Freiberg, Marc Fumaroli, David A. Levine, Daniel T. Michaels, Elizabeth Pilliod, Debra Pincus, and Gary Schwartz. 79 illustrations, bibliography of Marilyn Lavin's works, index.

"Reflects Marilyn Aronberg Lavin's innovative work in art and cultural history in both the print and digital realms. Contributors: Kirk Alexander, Horst Bredekamp, Nicola Courtright, David Freedberg, Jack Freiberg, Marc Fumaroli, David A. Levine, Daniel T. Michaels, Elizabeth Pilliod, Debra Pincus, Gary Schwartz. Seventy-seven illustrations, bibliography of Lavin's works, index"--Provided by publisher.

Since 2000, significant collections of Latest Miocene hominin fossils have been recovered from Chad, Kenya, and Ethiopia. These fossils have provided a better understanding of earliest hominin biology and context. Here, we describe five hominin teeth from two periods (ca. 5.4 Million-years-ago and ca. 6.3 Ma) that were recovered from the Adu-Asa Formation in the Gona Paleoanthropological Research Project area in the Afar, Ethiopia that we assign to either Hominina, gen. et sp. indet. or Ardipithecus kadabba. These specimens are compared with extant African ape and other Latest Miocene and Early Pliocene hominin teeth. The derived morphology of the large, non-sectorial maxillary canine and mandibular third premolar links them with later hominins and they are phenetically distinguishable and thus phyletically distinct from extant apes. Copyright © 2014 Elsevier Ltd. All rights reserved.

This article argues that the Acheulean is perhaps the longest lasting cultural–technological tradition in human history, dating from around 1.7 to 0.3 Mya and roughly corresponding to the time during which H. Erectus and H. Heidelbergensis lived in Africa. Unlike earlier Oldowan technology, Acheulean cores — handaxes, cleavers, and picks — were standardised, of predetermined shape and made on large cobbles and flakes. The extensive Acheulean archaeological record throughout Africa over 1.4 million years described is testimony to the success of this technology’s makers in different habitats, altitudes, and settings, but also to its apparent conservative cultural nature: a learned tradition passed on through thousands of generations of highly mobile hominin groups with small population sizes. Although there are differences between Early and Late Acheulean technology, the makers of these tools may have undergone more significant changes with respect to the use of other technologies, strategic land use, and social life.

In this article, I examine the statements and actions of two key informants, both of whom direct welfare programs in a district of the former East Berlin. I argue that this evidence points to a particular modality of political rationalization, which I dub organizational discourse. The entanglement of organizational discourse and governmentality are explored, as is the place of organizational discourse within both the liberal welfare state and the bygone state socialist regime.