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This article works to unsettle the use of transcription in qualitative inquiry by troubling the truth claims of transcribed text. Building on the hermeneutic phenomenology of Van Manen, it explores the way the researcher might “write through” transcribed text to return to the two-dimensional text space a more honest reading of lived experience. It also draws on Deleuze and Guattari’s rhizomatic thinking to explore the “gruesome multiplicities” present in reality—and the ways we might honor that multiplicity in research texts. Excerpts from an inquiry into the phenomenon of “reading as not a reader” are used to illustrate.

We investigate if CEO characteristics determine the choice of Political Action Committee (PAC) contributions by firms and if such participation leads to better firm performance. Using a unique, hand-collected database, we also focus on the identity of the politicians receiving PAC contributions to examine the impact of the value-relevance of such contributions. Examining data on corporate contributions made to candidates seeking federal office during the 2002, 2004, and 2006 election cycles, we find that CEO dominance and interest alignment influence strategic choices of firms with regards to establishing PACs. Our analysis of value-relevant contributions shows that firms prefer to donate to politicians representing the state of a firm's headquarters, validating the truth to the adage that all politics is local. However, these targeted political contributions do not have a discernible impact on firm performance.

Purpose: Austerity approaches in higher education require choosing the highest leverage strategies of increasing student satisfaction. Attending to student perceptions of program/service quality (SERVQUAL) is a means to identify areas that have the greatest return on investment. The paper aims to discuss these issues. Design/methodology/approach: This study explores how a program has applied the SERVQUAL model and survey to identify areas for growth. Findings: The survey of 57 students in a cohort-based doctoral program demonstrated the smallest gaps (highest satisfaction) with the domains of empathy (1.33) and responsiveness (1.30) and the lowest with reliability (2.03), tangibles (1.97) and assurance (1.90). Practical implications: While not all of the five dimensions are within the purview of a program to address (some may require funding that is determined at a college or university level), many of the gaps can be addressed by adopting procedures and policies that increase transparency so that students can moderate their expectations and faculty and staff can provide reliable information. Additionally, the use of the SERVQUAL model provided this program with specific, actionable information that could be used to improve the program. Originality/value: The study includes a review of studies that have applied the SERVQUAL model in higher education. The application of SERVQUAL to a cohort-based doctoral program to identify program improvements and steward program image fits into a gap in the extant literature. © 2019, Emerald Publishing Limited.

Heroin is a highly abused opioid that has reached epidemic status within the United States. Yet, existing therapies to treat addiction are inadequate and frequently result into rates of high recidivism. Vaccination against heroin offers a promising alternative therapeutic option but requires further development to enhance the vaccine’s performance. Hsp70 is a conserved protein with known immunomodulatory properties and is considered an excellent immunodominant antigen. Within an antidrug vaccine context, we envisioned Hsp70 as a potential dual carrier-adjuvant, wherein immunogenicity would be increased by co-localization of adjuvant and antigenic drug hapten. Recombinant Mycobacterium tuberculosis Hsp70 was appended with heroin haptens and the resulting immunoconjugate granted anti-heroin antibody production and blunted heroin-induced antinociception. Moreover, Hsp70 as a carrier protein surpassed our benchmark Her-KLH cocktail through antibody-mediated blockade of 6-acetylmorphine, the main mediator of heroin’s psychoactivity. The work presents a new avenue for exploration in the use of hapten-Hsp70 conjugates to elicit anti-drug immune responses.

Swearing is prevalent in our society, but the influence of such language choices on judgments of others is not well understood. This study examines how the composition of conversational dyads, speaker's gender, and use of profanity influence impressions. Participants (N = 138) were randomly assigned to read two conversations and rate target speakers (one male, one female). The conversations had neither, one, or both speakers using profanity and consisted of same- or mixed-gender dyads. The result is a 2 (target speaker, male/female) x 2 (dyad composition) x 3 (profanity) mixed design with speaker gender as the repeated measure. Speakers using profanity had poorer impression ratings on several variables, including overall impression, intelligence, and trustworthiness. Speakers swearing in mixed-gender dyads were rated as less sociable, and males swearing in mixed-gender dyads were rated as more offensive. Language choices matter, and more research is needed to understand the unconscious biases held against those who use profanity.

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Background: Few studies have explored changing patterns of alcohol consumption among young females and differences based on race/ethnicity. Objective: This study examined differences in alcohol consumption between black and white undergraduate females and compared trends in three different measures of alcohol consumption over a 10-year period from 2004 to 2014. Methods: The CORE Alcohol and Drug Survey was used to collect data from female undergraduates attending a public university in the northeastern USA. Classes were randomly selected into the sample; class acceptance was 68% and student participation was 96%. The chi-square test examined differences between groups and the Cochrane Armitage Test for Trend assessed changes over time. Results: In 2014, for every measure of alcohol consumption examined, a significantly larger percentage of white females engaged in the behavior compared to black females. Trend analysis from 2004 to 2014 demonstrated a narrowing of this gap. Controlling for age, any alcohol use in past 30 days and binge drinking in the past 2 weeks increased significantly for black females 21 years or older. Any alcohol use in the past 30 days decreased significantly for white females under 21 years. Conclusion: These findings introduce many questions which should be explored through additional research.

Evolutionary biologists tend to approach the study of the natural world within a framework of adaptation, inspired perhaps by the power of natural selection to produce fitness advantages that drive population persistence and biological diversity. In contrast, evolution has rarely been studied through the lens of adaptation's complement, maladaptation. This contrast is surprising because maladaptation is a prevalent feature of evolution: population trait values are rarely distributed optimally; local populations often have lower fitness than imported ones; populations decline; and local and global extinctions are common. Yet we lack a general framework for understanding maladaptation; for instance in terms of distribution, severity, and dynamics. Similar uncertainties apply to the causes of maladaptation. We suggest that incorporating maladaptation-based perspectives into evolutionary biology would facilitate better understanding of the natural world. Approaches within a maladaptation framework might be especially profitable in applied evolution contexts - where reductions in fitness are common. Toward advancing a more balanced study of evolution, here we present a conceptual framework describing causes of maladaptation. As the introductory article for a Special Feature on maladaptation, we also summarize the studies in this Issue, highlighting the causes of maladaptation in each study. We hope that our framework and the papers in this Special Issue will help catalyze the study of maladaptation in applied evolution, supporting greater understanding of evolutionary dynamics in our rapidly changing world.

Human-modified habitats rarely yield outcomes that are aligned with conservation ideals. Landscapes that are subdivided by roads are no exception, precipitating negative impacts on populations due to fragmentation, pollution, and road kill. Although many populations in human-modified habitats show evidence for local adaptation, rarely does environmental change yield outright benefits for populations of conservation interest. Contrary to expectations, we report surprising benefits experienced by amphibian populations breeding and dwelling in proximity to roads. We show that roadside populations of the wood frog, Rana sylvatica, exhibit better locomotor performance and higher measures of traits related to fitness compared with frogs from less disturbed environments located further away from roads. These results contrast previous evidence for maladaptation in roadside populations of wood frogs studied elsewhere. Our results indicate that altered habitats might not be unequivocally detrimental and at times might contribute to metapopulation success. While the frequency of such beneficial outcomes remains unknown, their occurrence underscores the complexity of inferring consequences of environmental change.

The neuromuscular junction (NMJ) of larval Drosophila is widely used as a genetic model for basic neuroscience research. The presynaptic side of the NMJ is formed by axon terminals of motor neurons, the soma of which reside in the ventral ganglion of the central nervous system (CNS). Here we describe a streamlined protocol for dissection and immunostaining of the Drosophila CNS and NMJ that allows processing of multiple genotypes within a single staining tube. We also present a computer script called Automated Image Analysis with Background Subtraction which facilitates identification of motor nuclei, quantification of pixel intensity, and background subtraction. Together, these techniques provide a pipeline for neuroscientists to compare levels of different biomolecules in motor nuclei. We conclude that these methods should be adaptable to a variety of different cell and tissue types for the improvement of efficiency, reproducibility, and throughput during data quantification. © 2019 The Author(s) 2019. Published by Oxford University Press.

Mantle plumes provide an attractive mechanism for generating short-duration, voluminous magmas in large igneous provinces (LIPs) while at the same time providing an explanation for the frequently associated break-up of supercontinents. This model has also been invoked for the Ferrar large igneous province (FLIP) in Antarctica, which zircon and baddeleyite U–Pb dating shows was emplaced over a short duration at 182.7 ± 0.5 Ma, contemporaneously with fragmentation of the supercontinent Gondwanaland. Here, we present platinum-group-element (PGE) and Os-isotopic data for the Basement Sill in the McMurdo Dry Valleys – a part of the FLIP – that challenge the plume interpretation. The Basement Sill samples studied are cumulate-textured gabbro to norite, and pyroxenite with minor ferro- or leuco-lithofacies with MgO ranging from 2 to 19 wt%. The 187Os/188Os values range from 0.1609 ± 0.003 (2σ) to 8.100 ± 1.600 (2σ); the minimum value overlaps with a previously published estimated initial 187Os/188Os ratio for Ferrar magmas of 0.145 ± 0.049 (2σ). The PGE abundance patterns for the Basement Sill define positive, convex-shaped slopes between the IPGE (Os, Ir and Ru) and PPGE (Pt, Pd and Rh). The most significant feature of the entire data set is the extreme sub-chondritic Os/Ir ratios (<0.33), values which are atypical of plume-derived magmas. These low Os/Ir ratios are more consistent with the alternative view that FLIP resulted from the decompression melting of mantle with a fossil subduction zone signature along the proto-Pacific margin of Gondwanaland, disaggregated by rifting related to plate rearrangements during supercontinent break-up. We propose that hydrated fossil subduction zones elsewhere on Earth might account for other short-lived voluminous magmatic events that form LIPs. The remarkably short duration of these events may be due to rapid decompression of hydrated mantle allowing instantaneous large-volume melting which then peters out quickly (<1 Myr) as H2O is expelled from the source rocks and into the melt. © 2018 Elsevier B.V.