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The leaves of the Mitragynine speciosia tree (also known as Kratom) have long been chewed, smoked, or brewed into a tea by people in Southeastern Asian countries, such as Malaysia and Thailand. Just this past year, the plant Kratom gained popularity in the United States as a "legal opioid" and scheduling it as a drug of abuse is currently pending. The primary alkaloid found in Kratom is a μ-opioid receptor agonist, mitragynine, whose structure contains a promising scaffold for immunopharmacological use. Although Kratom is regarded as a safe opioid alternative, here we report the LD 50 values determined for its two main psychoactive alkaloids, mitragynine and 7-hydroxymitragynine, as comparable to heroin in mice when administered intravenously. Given Kratom's recent emergence in the U.S., there is currently no diagnostic test available for law enforcement or health professionals, so we sought to design such an assay. Mitragynine was used as a starting point for hapten design, resulting in a hapten with an ether linker extending from the C9 position of the alkaloid. Bacterial flagellin (FliC) was chosen as a carrier protein for active immunization in mice, yielding 32 potential monoclonal antibodies (mAbs) for assay development. Antimitragynine mAbs in the range of micro- to nanomolar affinities were uncovered and their utility in producing a convenient lateral flow detection assay of human fluid samples was examined. Antibodies were screened for binding to mitragynine, 7-hydroxymitragynine, and performance in lateral flow assays. Two monoclonal antibodies were subcloned and further purified with 93 and 362 nM affinity to mitragynine. Test strip assays were optimized with a detection cut off of 0.5 μg/mL for mitragynine in buffer and urine (reflecting projected clinically relevant levels of drug in urine), which could be beneficial to law enforcement agencies and health professionals as the opioid epidemic in America continues to evolve. © 2018 American Chemical Society.

A growing number of organizations have difficulty scaling-up their IT infrastructure to handle their growing needs and increased resource demands. Digital Technology Platforms (DTPs) have been identified by Gartner, Inc. as one of the top 10 strategic technology trends of 2017. While DTPs may be mainstream and easily adopted by large enterprise-sized organizations, there is an opportunity for such platforms within Small and Mid-Size Businesses (SMBs). The bottom line is that computing and server hardware is expensive for SMBs. Furthermore, it may be difficult for SMBs to assess and price the labor and resources needed for a company to have acceptable performance while controlling costs. The purpose of this paper is to examine how cloud computing technologies are adopted by SMBs and the respective drivers associated with costs and capability that may reduce costs for an organization. This paper explores how four variables – Robust Capability, Limited Capability, Cost Constraint, and Resource Abundance interact to impact the adoption of DTPs within SMBs. Adopters of DTPs are classified as Efficient, Proactive, Resistive, and Reactive. With respect to adoption efficacy, a model is proposed for assessing the capability and resource readiness as correlated to SMB adoption of DTPs. A study of 12 SMBs and the implementations of DTPs is presented and posited with the proposed adoption model. Due to the extensive investments required in procuring infrastructure services –adoption enablement is imperative for SMB-sized organizations to realize a return on investment. Implications are discussed.

The primary purposes of the study were to investigate how often bullying occurs in libraries and whether bullying policies exist in libraries. The first survey questionnaire was sent to library personnel in the six New England states through statewide email distribution lists. Altogether 571 library staff members completed the survey. The second survey questionnaire was sent to large public and academic libraries in New England to see if they have anti-bullying policies in the workplace. The results of the study clearly showed there were significant reports of workplace bullying in all kinds of libraries. Nonetheless, not many libraries have policies that deal with this workplace challenge.

This new work is currently the only book devoted to the teaching of one of the most canonical and frequently taught American authors.In addition to a Preface by the noted Hawthorne scholar Larry J. Reynolds [University Distinguished Professor and Thomas Franklin Mayo Professor of Liberal Arts Department of English Texas A&M University] the contributors include well-known and rising teacher-scholars who offer theoretical and pedagogical approaches to Hawthorne's four published novels and a wide range of his short stories.The specially commissioned essays are designed to help teachers meet students at points of genuine interest and need. They incorporate biographical, literary, historical, and multidisciplinary scholarship. The studies are further grounded in specific contexts such as literature surveys, interdisciplinary humanities courses, upper division literature seminars, and study abroad courses.Special emphasis is given to the issues of gender, science, and visual culture (including film adaptations). Offering both theoretical and practical classroom resources, this anthology confirms the continued vitality of Hawthorne's work - his critiques of religious and moral authority are more relevant than ever in today's global political environment - even as it showcases how today's "Hawthorne" is more of a diverse amalgam of texts and perspectives than ever before. Given its diversity of approaches and authors (including essayists from Germany, Israel, and Sweden), Nathaniel Hawthorne in the College Classroom charts new paths for reading and teaching Hawthorne in the 21st century.

Since 2014, NASA's K2 mission has observed large portions of the ecliptic plane in search of transiting planets and has detected hundreds of planet candidates. With observations planned until at least early 2018, K2 will continue to identify more planet candidates. We present here 275 planet candidates observed during Campaigns 0-10 of the K2 mission that are orbiting stars brighter than 13 mag (in Kepler band) and for which we have obtained high-resolution spectra (R = 44,000). These candidates are analyzed using the vespa package in order to calculate their false-positive probabilities (FPP). We find that 149 candidates are validated with an FPP lower than 0.1%, 39 of which were previously only candidates and 56 of which were previously undetected. The processes of data reduction, candidate identification, and statistical validation are described, and the demographics of the candidates and newly validated planets are explored. We show tentative evidence of a gap in the planet radius distribution of our candidate sample. Comparing our sample to the Kepler candidate sample investigated by Fulton et al., we conclude that more planets are required to quantitatively confirm the gap with K2 candidates or validated planets. This work, in addition to increasing the population of validated K2 planets by nearly 50% and providing new targets for follow-up observations, will also serve as a framework for validating candidates from upcoming K2 campaigns and the Transiting Exoplanet Survey Satellite, expected to launch in 2018. © 2018. The American Astronomical Society. All rights reserved.

Research on college substance use and mental illness is limited and inconsistent. Measures of substance use, and anxiety and depressive symptoms, were completed by 1,316 undergraduates within a major drug transportation corridor. Hierarchical linear regressions were used to test associations between anxious and depressive symptoms and substance use (i.e., alcohol, cannabis, tobacco, cocaine, other amphetamines, sedatives, hallucinogens, and designer drugs). Depressive symptoms were associated with use of cannabis, tobacco, amphetamines, cocaine, sedatives, and hallucinogens. Anxiety symptoms were unrelated to substance use. These findings support the need for education and prevention at universities, emphasizing tobacco, cannabis, and certain “harder” drugs.

In this study, the literature in disability and higher education was examined, with a specific focus on assessment instruments. Published articles (n = 203) on development of new or refinement of existing instruments were reviewed for traits measured and psychometric rigor reported. Findings showed instruments are intended for professionals and students, and of the student instruments, broad categories are academic, nonacademic, and specific to a disability diagnosis. Not all instruments are limited to students with disabilities; many of the reviewed instruments can be utilized in higher-education settings on all students, faculty, and staff, regardless of disability. The implications of the findings undergird the urgency to prioritize disability as a facet of diversity within higher-education scholarship, and furthermore aid this prioritization by providing a catalogue of robust instruments to researchers and practitioners.

The Leading Arm (LA) of the Magellanic Stream is a vast debris field of H i clouds connecting the Milky Way and the Magellanic Clouds. It represents an example of active gas accretion onto the Galaxy. Previously, only one chemical abundance measurement had been made in the LA. Here we present chemical abundance measurements using Hubble Space Telescope/Cosmic Origins Spectrograph and Green Bank Telescope spectra of four AGN sightlines passing through the LA and three nearby sightlines that may trace outer fragments of the LA. We find low oxygen abundances, ranging from 4.0-2.0+2.0% solar to 12.6-4.16.0% solar, in the confirmed LA directions, with the lowest values found in the region known as LA III, farthest from the LMC. These abundances are substantially lower than the single previous measurement, S/H =35 ±7% solar, but are in agreement with those reported in the SMC filament of the trailing Stream, supporting a common origin in the SMC (not the LMC) for the majority of the LA and trailing Stream. This provides important constraints for models of the formation of the Magellanic System. Finally, two of the three nearby sightlines show high-velocity clouds with H i columns, kinematics, and oxygen abundances consistent with LA membership. This suggests that the LA is larger than traditionally thought, extending at least 20° further to the Galactic northwest. © 2018. The American Astronomical Society. All rights reserved.

Scholars have offered at least four distinct but interrelated conceptual frameworks for examining the relationship between militaries and the natural world.

The goal of the research is to determine the prognostic molecular pathological changes in components and composition, for human brain glioma gradings in comparison with normal tissues in three-dimensional Raman imaging profiles by visible Resonance Raman (VRR) imaging. <p> </p>VRR images from twenty-five specimens including three healthy tissues, one normal control, and twenty-one glioma tissues of grades II, II-III and III-IV with histology examination were measured and investigated using WITec300R confocal micro Raman imaging system with laser excitation of 532nm. <p> </p>Two-dimensional RR spectral mappings performed in 20&mu;m x 20&mu;m generated 400 images which integrated the intensity of the specific biochemical bonds as the third dimension. The three-dimension (3D) map demonstrated the spatial distributions of three selected sets of RR spectra of molecular biomarkers, and revealed significant differences in the spectra between normal and glioma tissues of different grades due to the composition changes in key molimageecules. These RR molecular spectral fingerprints have displayed: a clear enhancement of RR vibrational modes at 1129-1131cm^-1 and 2934cm^-1 which are supposed to be arising from lipoproteins; evident decreased RR vibrational modes at 1442cm^-1 and 2854cm^-1 which are from saturated fatty acids bonds in all-grades of glioma brain tissues compared with normal tissues; and the enhanced RR spectral modes of 1129 cm^-1 and 2938cm^-1 which suggest contribution from lactate. These findings may provide a novel proof for anaerobic glycolysis metabolic process in brain glioma cancer tissues that has been explained by Warburg effects.

Analyzing spectral or imaging data collected with various optical biopsy methods is often times difficult due to the complexity of the biological basis. Robust methods that can utilize the spectral or imaging data and detect the characteristic spectral or spatial signatures for different types of tissue is challenging but highly desired. In this study, we used various machine learning algorithms to analyze a spectral dataset acquired from human skin normal and cancerous tissue samples using resonance Raman spectroscopy with 532nm excitation. The algorithms including principal component analysis, nonnegative matrix factorization, and autoencoder artificial neural network are used to reduce dimension of the dataset and detect features. A support vector machine with a linear kernel is used to classify the normal tissue and cancerous tissue samples. The efficacies of the methods are compared.

Worldwide breast cancer incidence has increased by more than twenty percent in the past decade. It is also known that in that time, mortality due to the affliction has increased by fourteen percent. Using optical-based diagnostic techniques, such as Raman spectroscopy, has been explored in order to increase diagnostic accuracy in a more objective way along with significantly decreasing diagnostic wait-times. In this study, Raman spectroscopy with 532-nm excitation was used in order to incite resonance effects to enhance Stokes Raman scattering from unique biomolecular vibrational modes. Seventy-two Raman spectra (41 cancerous, 31 normal) were collected from nine breast tissue samples by performing a ten-spectra average using a 500-ms acquisition time at each acquisition location. The raw spectral data was subsequently prepared for analysis with background correction and normalization. The spectral data in the Raman Shift range of 750- 2000 cm-1 was used for analysis since the detector has highest sensitivity around in this range. The matrix decomposition technique nonnegative matrix factorization (NMF) was then performed on this processed data. The resulting leave-oneout cross-validation using two selective feature components resulted in sensitivity, specificity and accuracy of 92.6%, 100% and 96.0% respectively. The performance of NMF was also compared to that using principal component analysis (PCA), and NMF was shown be to be superior to PCA in this study. This study shows that coupling the resonance Raman spectroscopy technique with subsequent NMF decomposition method shows potential for high characterization accuracy in breast cancer detection.

The Sarbanes Oxley Act of 2002 (SOX) is documented to curb executive risk-taking and firm risk. Utilizing SOX as an exogenous shock on firm risk, we find that proxy fight threats are positively related to a firm’s total risk and idiosyncratic risk. Specifically, although firm risk generally decreases post-SOX, high proxy fight threats mitigate this change in firm risk. We also find that although firms adopt more conservative policies such as decreasing their leverage and payout post-SOX, these changes are mitigated by proxy fight threats. In sum, our findings indicate that proxy fights act as an external disciplinary mechanism, encourage executive risk-taking, and increase firm risk.

ACSM’S Exercise Testing and Prescription adapts and expands upon the assessment and exercise prescription-related content from ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription, 7th Edition, to create a true classroom resource. Fully aligned with the latest edition of ACSM’s flagship title, ACSM’s Guidelines for Exercise Testing and Prescription , this practical resource walks students through the process of selecting and administering fitness assessments, using Guidelines to interpret results, and drafting an exercise prescription that is in line with Guidelines parameters .Designed for today’s learners, the text is written in a clear, concise style, and enriched by visuals that promote student engagement. As an American College of Sports Medicine publication, the book offers the unsurpassed quality and excellence that has become synonymous with titles by the leading exercise science organization in the world.The nuances of fitness assessment and the particulars of crafting exercise prescriptions are explored in expansive sections throughout the book.A full section devoted to Special Populations prepares students to meet the needs of the full range of both typically healthy and special needs clients they’ll see in practice.Comprehensive case studies written by experts to reinforce practical applications of concepts.A wide range of online resources includes laboratory materials and activities that provide opportunities for hands-on learning, and a library of journal articles that helps students connect research to practice.100% alignment with the most up-to-date version of the ACSM’s Guidelines for Exercise Testing and Prescription enhances the learning experience, making it easy to go back and forth between Guidelines and the text.eBook available. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and much more.

ACSM’S Exercise Testing and Prescription adapts and expands upon the assessment and exercise prescription-related content from ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription, 7th Edition, to create a true classroom resource. Fully aligned with the latest edition of ACSM’s flagship title, ACSM’s Guidelines for Exercise Testing and Prescription , this practical resource walks students through the process of selecting and administering fitness assessments, using Guidelines to interpret results, and drafting an exercise prescription that is in line with Guidelines parameters .Designed for today’s learners, the text is written in a clear, concise style, and enriched by visuals that promote student engagement. As an American College of Sports Medicine publication, the book offers the unsurpassed quality and excellence that has become synonymous with titles by the leading exercise science organization in the world.The nuances of fitness assessment and the particulars of crafting exercise prescriptions are explored in expansive sections throughout the book.A full section devoted to Special Populations prepares students to meet the needs of the full range of both typically healthy and special needs clients they’ll see in practice.Comprehensive case studies written by experts to reinforce practical applications of concepts.A wide range of online resources includes laboratory materials and activities that provide opportunities for hands-on learning, and a library of journal articles that helps students connect research to practice.100% alignment with the most up-to-date version of the ACSM’s Guidelines for Exercise Testing and Prescription enhances the learning experience, making it easy to go back and forth between Guidelines and the text.eBook available. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and much more.

Boron compounds have been used extensively in organic synthesis for more than sixty years. Some of the best known reactions in synthesis, such as the Suzuki-Miyaura cross-coupling and the hydroboration reaction, involve boron compounds. Several natural products containing boron have been isolated in the last fifty years, including ionophoric macrodiolide antibiotics boromycin, borophycin, aplasmomycins A, B, and C, and tartrolons B, C, and E, as well as autoinducer-2. The study of compounds containing boronic acids for application in pharmaceuticals and materials science has grown tremendously over the last few decades. These include bortezomib, ixazomib, and tavaborole. Several more boron-based drugs are currently in clinical trials. Boron neutron capture therapy has the potential to provide a treatment for various cancers. In addition, materials bearing boronic acids are been studied as potential sensors for biological molecules, such as saccharides and glycoproteins that possess cis-1,2- or cis-1,3-diols.

We report the first measurements of transverse single-spin asymmetries for inclusive jet and jet+π± production at midrapidity from transversely polarized proton-proton collisions at √s=500 GeV. The data were collected in 2011 with the STAR detector sampled from 23 pb−1 integrated luminosity with an average beam polarization of 53%. Asymmetries are reported for jets with transverse momenta 6<pT<55 GeV/c and pseudorapidity |η|<1. Presented are measurements of the inclusive-jet azimuthal transverse single-spin asymmetry, sensitive to twist-3 initial-state quark-gluon correlators; the Collins asymmetry, sensitive to quark transversity coupled to the polarized Collins fragmentation function; and the first measurement of the “Collins-like” asymmetry, sensitive to linearly polarized gluons. Within the present statistical precision, inclusive-jet and Collins-like asymmetries are small, with the latter allowing the first experimental constraints on gluon linear polarization in a polarized proton. At higher values of jet transverse momenta, we observe the first nonzero Collins asymmetries in polarized-proton collisions, with a statistical significance of greater than 5σ. The results span a range of x similar to results from semi-inclusive deep-inelastic scattering but at much higher Q2. The Collins results enable tests of universality and factorization breaking in the transverse momentum-dependent formulation of perturbative quantum chromodynamics.

There can be no doubt that mobile technologies are here to stay. Global mobile traffic grew 74 percent in 2015 alone, with 563 million devices and connections added -- most of them tablets and Smartphones. This growth has been 4000-fold in the past 10 years and 400 million-fold in the past 15 years (Cisco, 2016). Mobile technologies permeate the lives of 21st century citizens as mainstays of organizational and institutional day-to-day operations, commerce, and communication and as tools used to support individuals' personal, social, and career responsibilities. In both the corporate and educational worlds, e- and m-learning and marketing with mobile technologies are moving forward at breakneck speed with, in many cases, a blurring of traditional sector boundaries. As neither the technology nor the uses are static, exploring practices and policies that underpin this quickly shifting mobile technology context is crucial for ensuring its intelligent, purposeful, and equitable use. This edited book provides a venue for researchers to share their work on mobile learning with a focus on uses for mobiles in informal settings and PK-20 classrooms, language learning, mobile gaming, leadership and policy issues, and what mobile learning in the future may be. It assists researchers and educators to consider and answer questions such as: What is "mobilelearning" today How can mobiles be used to enable learning How is mobile learning crossing or connecting economic, social, and/or cultural sectors How do specific cultural practices with media influence mobile learning (e.g

Workplace incivility remains a problem within the nursing profession. As nurse leaders, we must recognize and not ignore the complexity of cultures that have adapted incivility into the work environment. Nursing education is a discipline that requires collaborative team work, independent drive, and commitment. New nursing faculty experiencing incivility can use mindfulness-based meditation approaches to cope with uncivil behaviors experienced within the workplace. Nurse educators applying the concepts of mindfulness can learn how to provide themselves self-care by reducing stress, as enhanced daily awareness of peace and calm are incorporated into their lifestyle. Mindfulness provides a realization that control can only be given to other persons when an individual allows or accepts another's negative behaviors. Awareness of the value and importance of oneself can assist the nurse educator experiencing incivility to maintain his or her emotional, physical, and spiritual health despite the volatility of the work environment.