Search

Context.-Distinguishing chromophobe renal cell carcinoma (chRCC), especially in the presence of eosinophilic cytoplasm, from oncocytoma on hematoxylin-eosin can be difficult and often requires time-consuming ancillary procedures that ultimately may not be informative. Objective.-To explore the potential of multiphoton microscopy (MPM) as an alternative and rapid diagnostic tool in differentiating oncocytoma from chRCC at subcellular resolution without tissue processing. Design.-Unstained, deparaffinized tissue sections from 27 tumors (oncocytoma [n = 12], chRCC [n = 12], eosinophilic variant of chRCC [n = 1], and atypical oncocytic renal neoplasm [n = 2]) were imaged with MPM. Morphologic evaluation and automated quantitative morphometric analysis were conducted to distinguish between chRCC and oncocytoma. Results.-The typical cases of oncocytomas (12 of 12) and chRCC (12 of 12) could be readily differentiated on MPM based on the morphologic features similar to hematoxylin-eosin. The most striking MPM signature of both of the tumors was the presence of autofluorescent intracytoplasmic granules, which are not seen on hematoxylin-eosin-stained slides. Although we saw these granules in both types of tumors, they appeared distinct, based on their size, shape, cytoplasmic distribution, and autofluorescence wavelengths, and were valuable in arriving at a definitive diagnosis. For oncocytomas and chRCC, high diagnostic accuracies of 100% and 83.3% were achieved on blinded MPM and morphometric analysis, respectively. Conclusions.-To the best of our knowledge, this is the first demonstration of MPM to distinguish chRCC from oncocytoma in fixed tissues. Our study was limited by small sample size and only a few variants of oncocytic tumors. Prospective studies are warranted to assess the utility of MPM as a diagnostic aid in oncocytic renal tumors. © Copyright 2018 College of American Pathologists.

This study confronts the questionable reliability and accuracy of field test kits distributed globally to determine arsenic in drinking water. Because kits are the primary method of arsenic analysis in the areas most affected, an alternate, nontoxic formulation is needed to provide accurate results. Hypothesizing that introducing silver nitrate as the reagent in test kits could successfully substitute for restricted mercuric bromide, the study found that the reformulated kits provided reliable, precise, and accurate results over a broader range of contamination. Digital image analysis was used to examine the blue color value produced when arsine reacts with silver nitrate impregnated test strips. An optimal concentration of AgNO3 exhibiting the greatest linearity was determined by graphical comparison and the color intensity of the strips observed to be inversely proportional to the concentration of As (III). Adapted field test kits were then constructed to examine water samples ranging in arsenic contamination from 0 to 50 μg L−1. A series of reactions was completed to demonstrate reproducibility and test for the accuracy of the procedure. Statistical examination of colorimetrically quantified results confirmed the hypothesis that silver nitrate can reliably and precisely expand the kit’s range of detection while maintaining its low cost, quick assessment, and uncomplicated technique. This new method, using 0.4% m/v AgNO3 as a reagent for the Gutzeit reaction, was able to distinguish between concentrations of 0, 5, 10, 15, and 50 μg L−1 at the 95% confidence level. © 2018, Springer International Publishing AG, part of Springer Nature.

VRR spectroscopy was used for BCC and normal skin tissues with 532nm excitation. The spectra showed significant changes in collagen, carotenoids and lipids. These enhanced fingerprints demonstrate a potential use as label-free pathology method. © 2018 The Author(s).

This chapter describes and analyzes an ongoing project of memorialization of the Armenian Genocide in Turkey. It explores the importance of memorialization for collective historical memory, especially in situations where historical memory has been subverted by genocide denial. Among many aspects of memorialization, its role in bearing witness is explored and highlighted. Three components of the memory project are described: (1) the photography exhibitions, (2) the publications, and (3) the creation of memory sites. The project centers on the story of the Dildilian family in Ottoman Turkey before, during, and after the genocide, covering the years 1872–1923. A microhistory of the life of the Armenian minority is chronicled by means of the personal memories and stories of members of the family. The history is richly illustrated with photographs and drawings that serve as the basis of the photography exhibitions and books. Exhibitions and associated talks and panels have taken place in Istanbul, Merzifon, Diyarbakir, and Ankara. The chapter describes and analyzes the reaction of the Turkish public to the project.

This book explores the memory and representation of genocide as they affect individuals, communities and families, and artistic representations. It brings together a variety of disciplines from public health to philosophy, anthropology to architecture, offering readers interdisciplinary and international insights into one of the most important challenges in the 21st century. The book begins by describing the definitions and concepts of genocide from historical and philosophical perspectives. Next, it reviews memories of genocide in bodies and in societies as well as genocide in memory through lives, mental health and transgenerational effects. The book also examines the ways genocide has affected artistic works. From poetry to film, photography to theatre, it explores a range of artistic approaches to help demonstrate the heterogeneity of representations. This book provides a comprehensive and wide-ranging assessment of the many ways genocide has been remembered and represented. It presents an ideal foundation for understanding genocide and possibly preventing it from occurring again

IntroductionIntrapartum emergencies occur infrequently but require a prompt and competent response from the midwife to prevent morbidity and mortality of the woman, fetus, and newborn. Simulation provides the opportunity for student midwives to develop competence in a safe environment. The purpose of this study was to determine the inter-rater reliability of the McMahon Competence Assessment Instrument (MCAI) for use with student midwives during a simulated shoulder dystocia scenario. MethodsA pilot study using a nonprobability convenience sample was used to evaluate the MCAI. Content validity indices were calculated for the individual items and the overall instrument using data from a panel of expert reviewers. Fourteen student midwives consented to be video recorded while participating in a simulated shoulder dystocia scenario. Three faculty raters used the MCAI to evaluate the student performance. These quantitative data were used to determine the inter-rater reliability of the MCAI. ResultsThe intraclass correlation coefficient (ICC) was used to assess the inter-rater reliability of MCAI scores between 2 or more raters. The ICC was 0.86 (95% confidence interval, 0.60-0.96). Fleiss's kappa was calculated to determine the inter-rater reliability for individual items. Twenty-three of the 42 items corresponded to excellent strength of agreement. DiscussionThis study demonstrates a method to determine the inter-rater reliability of a competence assessment instrument to be used with student midwives. Data produced by this study were used to revise and improve the instrument. Additional research will further document the inter-rater reliability and can be used to determine changes in student competence. Valid and reliable methods of assessment will encourage the use of simulation to efficiently develop the competence of student midwives.

This chapter presents a review of the multi-scalar complexities of coastal sustainability challenges. It focuses on three discrete vignettes of innovation, which range from a novel and emerging innovation, a maturing innovation and an innovation which has become mainstream and part of the prevailing socio-technical regime. The first vignette focuses on 3D ocean farming off the coast of Connecticut in Long Island Sound, USA, as an example of an emerging niche-level innovation. The second vignette discusses the development of offshore wind energy capacity in Liverpool Bay, UK as an example of a socio-technical innovation that is more mature. The final vignette discusses containerisation as an example of a fully matured socio-technological change. The chapter argues that a spatial perspective on transition is critical to adequately account for uneven development processes and to recognise the heterogeneity of different places in terms of potential for low-carbon transition. © 2019 selection and editorial matter, C. Patrick Heidkamp and John Morrissey.

This case study features a class of sixth-grade students and their science teacher enacting a curriculum designed to teach the particulate nature of matter and phase changes. The class used a mobile device with several applications that supported reading, writing, viewing, and modeling. We examine the role of the teacher, the device, the peers, and the curriculum itself in scaffolding student learning.

In nonfiction, poetry, short fiction, artwork, and detailed interviews, States of the Union collects reflections from everyday Americans on the 2016 presidential election. -Publisher Web Site.

This paper examines the literature to try to explain the concept of inflation targeting. There are at present two competing monetary policy rules: (1) targeting rules and (2) instrument rules. The objective of this paper is to review the relative merits of these two monetary policy rules. The debate between using either an inflation targeting rule or an instrument rule debate displays the lack of consensus among economists concerning the proper specification and underlying assumptions of the inflation-targeting model which is suited for the analysis of key monetary policy issues. The paper also examines what recent studies have found about the effect of inflation targeting on emerging markets. These studies have shown that inflation targeting has been largely beneficial to emerging markets.

This chapter identifies an orchestrated effort in “Republika Srpska”—an entity within Bosnia and Herzegovina that was recognized by the 1995 Dayton Peace Agreement − that is designed to prevent survivors of the genocide from erecting memorials to the victims in such locations as Višegrad, Prijedor, and Foča. While memorials for victims have been prohibited, and survivors have been prevented from using the term “genocide,” memorials to the perpetrators have been installed in the center of Višegrad, and near the Trnopolje concentration camp in Prijedor Municipality. In the hills above Sarajevo, in a location from which the city’s residents were attacked during the siege, a plaque honoring indicted war criminal Ratko Mladić has been installed. Accordingly, this chapter considers the extent to which the discriminatory practices regarding memorials in Republika Srpska constitute a violation of human rights. Further, the chapter argues that, following Raphael Lemkin’s definition of genocide, the prohibitive policies in Republika Srpska with respect to memorials and commemorative practices constitute nothing less than a continuation of the genocide, a second phase of the genocide designed to ensure the permanent erasure of a world that was destroyed. These human rights violations and the continuation of the genocide are a troubling testament to the failure of the international community in Bosnia, and to the problematic legacy of the Dayton Peace Agreement.