Your search

There is still a lack of reliable intraoperative tools for glioma diagnosis and to guide the maximal safe resection of glioma. We report continuing work on the optical biopsy method to detect glioma grades and assess glioma boundaries intraoperatively using the VRR-LRRTM Raman analyzer, which is based on the visible resonance Raman spectroscopy (VRR) technique. A total of 2220 VRR spectra were collected during surgeries from 63 unprocessed fresh glioma tissues using the VRR-LRRTM Raman analyzer. After the VRR spectral analysis, we found differences in the native molecules in the fingerprint region and in the high-wavenumber region, and differences between normal (control) and different grades of glioma tissues. A principal component analysis–support vector machine (PCA-SVM) machine learning method was used to distinguish glioma tissues from normal tissues and different glioma grades. The accuracy in identifying glioma from normal tissue was over 80%, compared with the gold standard of histopathology reports of glioma. The VRR-LRRTM Raman analyzer may be a new label-free, real-time optical molecular pathology tool aiding in the intraoperative detection of glioma and identification of tumor boundaries, thus helping to guide maximal safe glioma removal and adjacent healthy tissue preservation.

We report a measurement of cumulants and correlation functions of event-by-event proton multiplicity distributions from fixed-target Au+Au collisions at √sNN = 3 GeV measured by the STAR experiment. Protons are identified within the rapidity (y) and transverse momentum (pT) region −0.9<y<0 and 0.4<pT<2.0 GeV/c in the center-of-mass frame. A systematic analysis of the proton cumulants and correlation functions up to sixth order as well as the corresponding ratios as a function of the collision centrality, pT, and y are presented. The effect of pileup and initial volume fluctuations on these observables and the respective corrections are discussed in detail. The results are compared to calculations from the hadronic transport UrQMD model as well as a hydrodynamic model. In the most central 5% collisions, the value of proton cumulant ratio C4/C2 is negative, drastically different from the values observed in Au+Au collisions at higher energies. Compared to model calculations including lattice QCD, a hadronic transport model, and a hydrodynamic model, the strong suppression in the ratio of C4/C2 at 3 GeV Au+Au collisions indicates an energy regime dominated by hadronic interactions.

Capstone Handbook has been produced as a practical guide for students in the final year of their MSW program. It is intentionally designed to provide brief overviews of the lock-step approach to completing a capstone or thesis project and includes activities to help partialize the steps that will culminate in the completion of the capstone. It contains 30 chapters spanning two semesters with each chapter providing chapter objectives, an introduction, chapter content, a summary of the chapter, end of chapter exercises, references and ancillary material. An overview of all key concepts required in a typical capstone provides students with a practical resource to guide them through the process of creating capstone proposals and final products. Lastly, the eBook’s intent is to afford students with some structure for getting starting by providing a number of templates.

Libraries are adapting to the changing times by providing mobile services. One hundred fifty-one libraries were chosen based on circulation, with at least one library or library system from each state, to explore the diverse services provided to mobile users across the United States. According to the data, mobile apps, mobile reference services, mobile library catalogs, and mobile printing are among public libraries’ most-frequently offered services, as determined by mobile visits, content analysis, and librarian survey responses. Every library examined had at least one mobile website, mobile catalog, mobile app, or webpage adapted for a mobile device. Following the COVID-19 outbreak, services such as mobile renewal, subscriber database access, mobile reservations, and the ability to interact with a librarian were expanded to allow better communication with customers—all from the comfort and safety of their own homes. Libraries are continually looking for innovative methods to assist their mobile customers as the world changes.

Diabetes distal symmetrical peripheral neuropathy (DSPN) is the most prevalent form of neuropathy in industrialized countries, substantially increasing risk for morbidity and pre-mature mortality. DSPN may manifest with small-fiber disease, large-fiber disease, or a combination of both. This review summarizes: (1) DSPN subtypes (small- and large-fiber disease) with attention to clinical signs and patient symptoms; and (2) technological diagnosis and screening for large- and small-fiber disease with inclusion of a comprehensive literature review of published studies from 2015-present (N = 66). Review findings, informed by the most up-to-date research, advance critical understanding of DSPN large- and small-fiber screening technologies, including those designed for point-of-care use in primary care and endocrinology practices.

Background:Moral distress has detrimental effects on nurses which impacts the entire healthcare cycle. Described as a crescendo effect, resolved situations of moral distress leave residue on the nurse with three potential outcomes: moral numbing, conscious objection to the situation, and burnout.Objective:This metaethnography strives to achieve a fuller understanding of moral distress by interpreting the body of qualitative work of moral distress in emergency and critical care nurses.Method:This study used the Noblit and Hare?s approach of interpretative synthesis. Ten studies met the criteria and were used in this synthesis.Ethical considerations:Ethical issues were minimal since no human subjects were involved. Ethical requirements were respected in all study phases.Results:The synthesis of qualitative research on moral distress resulted in one central theme, ?the battle within,? and five subthemes.Conclusions:The unique nature of this nursing specialty resulted in a lasting inner conflict for nurses that is consistent with the previously described crescendo effect. The effects are complex and long lasting and may potentially affect the nurses? future patient care.

Purpose The purpose of this article is to provide conceptual clarification of secondary traumatic stress (STS) in nurses. Background As an empathetic helping profession, nurses are at increased risk for STS. Interchangeable usage of related terms among multidisciplinary literature has resulted in lack of conceptual clarity resulting in conflation of terms. Conceptual clarity is necessary for a foundation for further research on treatment. Methods Rodgers' evolutionary model of concept analysis. Results Nurses are predisposed to STS due to exposure, empathy, bonding, and personal factors. Essential attributes were found to be posttraumatic stress disorder-like symptoms, biological symptoms, social symptoms, and psychological symptoms. Resultant consequences included an altered worldview, interpersonal difficulties, and decreased occupational commitment. Conclusion This concept analysis, the first focusing on STS, provides conceptual clarity and a concept map of STS within the nursing population.

本书将儿童,童年回忆和西班牙内战联系在一起,提出了"佛朗哥儿童"这个新概念.在童年研究和历史回忆研究的二元框架下,作者分析了"佛朗哥儿童"在西班牙20世纪后半叶至今的代表性文学影视作品,以此揭示出儿童在西班牙政治中的重要性,并呈现了西班牙近几十年来的历史和文化走向

The mayoral archive includes both official and personal documents that can be used for research on various aspects of New Haven's history. Much of the DeStefano collection, for example, has various reports and studies on economic development and school construction projects, which were key to his administration.The Hilton C. Buley Library hosts a growing collection of mayoral papers from four New Haven mayors: Biagio “Ben” DiLieto (1980–90), John Daniels (1990–94), John DeStefano Jr. (1994–2014) and Toni Harp (2014–20). The materials are available to the public by appointment. Many items—including the full DeStefano papers—are available in a digital archive through the Buley Library website or the Connecticut Digital Archive portal. Jackie Toce, librarian and head of technical services at Buley Library, has spent the last seven years leading the digitization efforts for the archive, one of the reasons DeStefano donated the materials to Southern.4 Buley Library will host an exhibition and formal unveiling of the archive in late October 2021, which will run through the end of the year.

Aims and objectives:This study investigates the effects of language loss on bilingual autobiographical memory. More specifically, the study focuses on whether severe language loss would lead to any linguistic changes and/or interfere with how memories are recalled and shared.Methodology:Autobiographical memories were elicited with the help of a cued-recall technique and memory questionnaire from two groups of immigrants?attriters (who experienced significant language loss) and bilinguals (who retained their first language proficiency).Data and analysis:The data set consisted of pre-immigration memories that were originally encoded in the first language, Russian. The frequency of recall (i.e., sharing memories with others as well as reminiscing) and linguistic components (i.e., words) of memories elicited from the attriters and bilinguals were analyzed quantitatively and qualitatively.Findings and conclusion:Overall, attriters were able to recall memories that were originally encoded in the forgotten language. They also reported reminiscing about their pre-immigration memories and sharing their memories with others. However, attriters revealed that the pre-immigration memories came to them with words in the second language, English, which was not the case with bilinguals. Attriters also reframed memories for several Russian culture-specific items and events. This finding is indicative of memory re-encoding?a phenomenon when memories are updated, stored, and subsequently retrieved with added information. While this finding points to the bilingual mind?s ability to adapt to language loss, it may also suggest linguistic and cultural assimilation under the influence of the new language and culture.Originality:This is the first investigation of autobiographical memory in bilinguals with severe language loss that highlights the malleability and adaptability of the bilingual mind as well as the importance of language maintenance.

Background:Little is known about the adoption by athletic administrators (AAs) of exertional heat illness (EHI) policies, and the corresponding facilitators and barriers of such policies within high school athletics. This study describes the adoption of comprehensive EHI policies by high school AAs and explores factors influencing EHI policy adoption.Hypothesis:We hypothesized that <50% of AAs would report adoption of an EHI policy, and that the most common facilitator would be access to an athletic trainer (AT), whereas the most common barrier would be financial limitations.Study Design:Cross-sectional.Level of Evidence:Level 4.Methods:A total of 466 AAs (82.4% male; age, 48 ± 9 years) completed a validated online survey to assess EHI prevention and treatment policy adoption (11 components), as well as facilitators and barriers to policy implementation. Access to athletic training services was ascertained by matching the participants? zip codes with the Athletic Training Locations and Services Project. Policy adoption, facilitators, and barriers data are presented as summary statistics (proportions, interquartile range (IQR)). A Welch t test evaluated the association between access to athletic training services and EHI policy adoption.Results:Of the AAs surveyed, 77.9% (n = 363) reported adopting a written EHI policy. The median of EHI policy components adopted was 5 (IQR = 1,7), with only 5.6% (n = 26) of AAs reporting adoption of all policy components. AAs who had access to an AT (P = 0.04) were more likely to adopt a greater number of EHI-related policies, compared with those without access to an AT. An AT employed at the school was the most frequently reported facilitator (36.9%).Conclusion:Most AAs reported having written EHI policy components, and access to an AT resulted in a more comprehensive policy.Clinical Relevance:Employment of an AT within high school athletics may serve as a vital component in facilitating the adoption of comprehensive EHI policies.