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(1) Understanding the thermal sensitivity of reproductive interactions is crucial given global warming. Previous studies have almost exclusively focused on interactions before mating, even though important interactions between the sexes also occur after mating (e.g., gamete interactions), which are likely affected by temperature. (2) Thus, it remains unknown how temperature affects the influence of female reproductive fluid on sperm performance, thereby altering female control over fertilization (cryptic female choice). This gap limits our understanding of how sexual selection changes with seasonal temperature fluctuations and temperatures outside the range of historical norms. (3) We tested how temperatures relevant to current conditions and climate change projections influence the mechanisms underlying cryptic female choice in a marine fish, Symphodus ocellatus. Under typical thermal conditions, female reproductive fluid enhances sperm velocity and biases fertilization dynamics to favor preferred, dominant males over sneaker males. (4) We find that warmer temperatures decrease female influence on sperm velocity, especially for dominant males. This results in dominant males having slower sperm than sneaker males at warmer temperatures, reducing the expected paternity of preferred, dominant males. (5) Our results highlight that considering the thermal sensitivity of female-male interactions that occur after mating will be essential for understanding how seasonal variation and climate change can influence fertility, reproduction, and sexual selection.

(1) Understanding the thermal sensitivity of reproductive interactions is crucial given global warming. Previous studies have almost exclusively focused on interactions before mating, even though important interactions between the sexes also occur after mating (e.g., gamete interactions), which are likely affected by temperature. (2) Thus, it remains unknown how temperature affects the influence of female reproductive fluid on sperm performance, thereby altering female control over fertilization (cryptic female choice). This gap limits our understanding of how sexual selection changes with seasonal temperature fluctuations and temperatures outside the range of historical norms. (3) We tested how temperatures relevant to current conditions and climate change projections influence the mechanisms underlying cryptic female choice in a marine fish, Symphodus ocellatus. Under typical thermal conditions, female reproductive fluid enhances sperm velocity and biases fertilization dynamics to favor preferred, dominant males over sneaker males. (4) We find that warmer temperatures decrease female influence on sperm velocity, especially for dominant males. This results in dominant males having slower sperm than sneaker males at warmer temperatures, reducing the expected paternity of preferred, dominant males. (5) Our results highlight that considering the thermal sensitivity of female-male interactions that occur after mating will be essential for understanding how seasonal variation and climate change can influence fertility, reproduction, and sexual selection.

<p>This report describes features of actinobacteriophages assigned to subcluster EK2.  Additional phages may have been added to the phagesDB database since the generation of this report.</p>

La Colonia Digital Archive: New Haven's Italian American Community, 1890–1930 is an open-access digital humanities project documenting the professional and civic life of New Haven's Italian American community between 1890 and 1930. The archive is based on Antonio Cannelli's La Colonia Italiana di New Haven (1921), a 373-page Italian-language volume combining a community Who's Who with a survival guide for new immigrants. Cannelli documented 248 individuals and more than 90 businesses, including physicians, attorneys, pharmacists, musicians, grocers, and bankers. Cannelli published his volume in 1921, the same year that Nicola Sacco and Bartolomeo Vanzetti went on trial for murder in Massachusetts; they were convicted on July 14, 1921, and sentenced to death in a case that became an international cause célèbre and a defining watershed of anti-immigrant sentiment directed specifically at Italians. The trial unfolded against a broader landscape of systematic exclusion: the Emergency Quota Act of 1921 had passed just months earlier, sharply restricting Southern and Eastern European immigration, and Italians faced sustained targeting, marginalization, and persistent characterization as unskilled, unassimilable, and threatening. Cannelli's documentation was deliberate advocacy in precisely this climate: a counter-narrative assembled to demonstrate the professional achievement, civic engagement, and cultural diversity and richness of a community that dominant American discourse refused to acknowledge. La Colonia Digital Archive makes that narrative searchable and accessible to researchers, descendants, and the general public, plotting archival documents and photographs onto contemporary maps of New Haven and the surrounding area. The archive is currently in active pre-launch development. Public release is planned for 2026, with ArcGIS StoryMap components to be added through 2026–2027.

Preventive health behaviors play a critical role in reducing disease risks and improving public health outcomes, particularly among vulnerable populations such as women in rural communities. However, limited research has explored the determinants of intentions to adopt preventive health behaviors in developing contexts among women in rural communities. This study applies and extends the Theory of Planned Behavior (TPB) to examine these determinants in Algeria. A cross-sectional study was conducted using convenience sampling among 205 women in rural communities aged 20–60 years across five Algerian cities. Data were collected through a self-administered questionnaire and analyzed using hierarchical multiple regression. The results indicate that attitude, subjective norms, and perceived behavioral control have significant positive effects on behavioral intention. The inclusion of health literacy significantly enhances the model’s explanatory power, with higher literacy associated with stronger intentions. In contrast, perceived healthcare discrimination does not have a statistically significant effect. The extended model explains 57.5% of the variance in behavioral intention. These findings underscore the importance of psychosocial and informational factors in shaping preventive health intentions and support the extension of TPB in this context. They also provide practical implications for policymakers and healthcare practitioners to design targeted social marketing interventions aimed at improving preventive health behaviors and reducing health disparities among women in rural communities. © 2026 by the authors.

Climate change is increasingly destabilizing affordable housing systems by transforming occasional disaster-related damage into a persistent driver of housing loss and displacement. Low-income households and renters are disproportionately exposed to climate-related hazards because historically affordable housing has often been developed in areas vulnerable to flooding, extreme heat, and wildfires. In the United States, the Federal Emergency Management Agency (FEMA) administers major climate adaptation initiatives through its Hazard Mitigation Assistance programs. Although these programs are primarily designed to reduce disaster risk and financial losses, their broader implications for housing affordability and community stability remain insufficiently examined. This narrative policy review synthesizes interdisciplinary research on disaster risk reduction, climate adaptation, housing affordability, and equity governance to examine how FEMA hazard mitigation funding influences affordable housing outcomes in climate-vulnerable communities. The review finds that widely used mitigation strategies, particularly property acquisition and demolition, can unintentionally reduce the supply of affordable housing and displace tenants without guaranteeing replacement housing. In contrast, in-situ mitigation and community-scale resilience measures that could preserve housing stability are less frequently implemented. Institutional barriers further complicate the integration of housing affordability goals within hazard mitigation policy. These barriers include benefit–cost analysis frameworks that undervalue social outcomes, fragmented governance between emergency management and housing institutions, and short planning horizons that overlook long-term housing impacts. By synthesizing these insights, the article reframes hazard mitigation as an investment in social infrastructure and proposes a housing-centered framework for climate adaptation policy. The findings highlight that preserving affordable housing and preventing displacement must become central objectives within hazard mitigation strategies to ensure equitable and effective climate resilience. Without housing stability, climate adaptation programs risk exacerbating the very vulnerabilities they are intended to address.

Climate change constitutes a major market failure because greenhouse gas emissions are not priced to reflect their social costs. Carbon pricing has become a central policy instrument, yet its effectiveness varies across contexts. This review evaluates the performance of carbon taxes and emissions trading systems by examining their environmental, economic, and equity outcomes. The analysis applies a systematic review framework covering peer-reviewed studies, meta-analyses, and international policy assessments published between 2008 and 2025. Evidence is synthesized across three dimensions: emissions reductions, innovation and structural change, and distributional impacts. The literature consistently shows that carbon pricing reduces emissions when price signals are strong, credible, and increase predictably over time. Jurisdictions with rising tax schedules or progressively tightening emissions caps achieve the most durable mitigation. Carbon pricing also stimulates low-carbon innovation and supports long-term structural change, especially when combined with complementary policies. Distributional outcomes vary, but equity improves significantly when revenues are returned through rebates or tax reductions. Overall effectiveness depends more on design quality and policy coherence than on whether pricing is delivered through taxes or trading systems. Credible long-term price paths, broad sectoral coverage, transparent governance, and equitable revenue use are essential conditions for achieving sustained environmental and socio-economic benefits.

<p>This report describes features of actinobacteriophages assigned to subcluster AZ1.  Additional phages may have been added to the phagesDB database since the generation of this report.</p>

Abstract Description The identification and prioritization of cancer-specific neoepitopes from next-generation sequencing data for personalized immunotherapies such as cancer vaccines remains challenging and requires the use of complex bioinformatics approaches. Here, we present GeNeo2, an updated version with enhanced features of the GeNeo toolbox for predicting neoepitopes from matched tumor/normal exome sequencing data coupled with tumor RNA-Seq data (Al Seesi et al., 2023). Unlike GeNeo, which identifies neoepitopes generated by single nucleotide variants, GeNeo2 also predicts neoepitopes generated by somatic indels. A distinguishing feature in GeNeo2 is that it integrates tools for analyzing mass spectrometry immunepeptidomic data, which can reveal neoantigens derived from both canonical and noncanonical sources. Finally, GeNeo2 integrates novel machine-learning approaches to improve the accuracy of somatic variant calling and peptide identification from mass spectrometry data. GeNeo2 tools can be accessed via web-based interfaces deployed on a Galaxy portal accessible at https://neo.engr.uconn.edu/. A virtual machine image for running GeNeo2 locally is also available to academic users upon request. Topic Categories Computational and Systems Immunology (COMP)

This article explores a collaborative initiative undertaken by a state university aimed at implementing and expanding an Early College Program. The conceptual framework, practical strategies, collaborative efforts and background of this initiative are presented. With a focus on improving college access for all, the article introduces the university's efforts to promote an inclusive Early College Program accessible to high-need students in particular. This collaborative approach highlights the importance of fostering collaboration among both internal and external partners of Institutions of Higher Education (IHE). By sharing insights into the program design and implementation, the article aims to inspire similar initiatives and contribute to the ongoing dialogue promoting early college experiences for all.