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Background Stimulant use disorder (StUD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. This comorbidity complicates treatment and worsens clinical outcomes. Despite the high prevalence, shared vulnerability and clinical relevance of this comorbidity, evidence on effective pharmacotherapies among individuals with this dual diagnosis remains limited. Materials and methods This systematic review protocol is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement and will include randomized controlled trials involving adults with comorbid StUD (cocaine, amphetamines, or methamphetamines) and ADHD. The following databases will be searched: PubMed, Embase, Scopus, and Web of Science. Covidence will be used to support independent screening and data extraction. Two reviewers will independently screen studies (title/abstract and full text). One author will extract data, which will be independently verified by a second reviewer. Quality assessment of included articles will be assessed using the Cochrane Risk of Bias instrument, and certainty of the evidence for each outcome will be assessed using Grading of Recommendations, Assessment, Development and Evaluations (GRADE) methodology. Primary outcomes include duration of continuous abstinence, odds of stimulant-negative urine samples, ADHD symptom changes, and medication adverse events. Where feasible, meta-analyses will be conducted using random-effects models. Significance and dissemination This review will synthesize existing evidence on the efficacy of pharmacotherapies (stimulants and non-stimulants) for individuals with co-occurring StUD and ADHD. The results of this study will likely inform clinical practice by evaluating outcomes such as reduction in stimulant use and abstinence, and improvement in ADHD symptoms. Findings will be disseminated through peer-reviewed publication and presentations to reach both clinical and academic audiences. Systematic review registration PROSPERO, CRD420250655356.

Modeling lipase activity aids researchers in optimizing features such as temperature, pH, and substrate concentration to boost enzyme performance. This is essential in biotechnology for progressing the productivity and yield of processes such as fermentation, biodiesel production, and bioremediation. Fermentation is a highly complex, multivariable, and non-linear biotechnological process that produces bioactive materials. This study leverages artificial neural networks (ANN) to predict lipase activity in batch fermentation processes, addressing the inherent challenges in weight learning optimization often encountered with traditional algorithms like Backpropagation (BP). Several metaheuristic algorithms were employed to optimize the Multilayered Perceptron (MLP) structure and weights, including moth-frequency optimization (MFO), Particle Swarm Optimization (PSO), Dandelion Optimizer Algorithm (DO), Crow Search Algorithm (CSA), and Salp Swarm Algorithm (SSA) to overcome these limitations. Among the tested algorithms, MFO emerged as the most effective approach, achieving superior performance in weight learning with the best fitness value (i.e., mean square error (MSE)) of 0.6006. MFO-optimized ANN models deliver the most accurate predictions for lipase activity, highlighting their potential as a powerful tool for advancing industrial fermentation process optimization. © 2025 IEEE.

This pathbreaking book brings to bear a sweeping body of contemporary intersectional feminist work to disrupt the entire discipline of criminology. Women have been largely absent from criminological theory, research, policy, and practice. This fresh, conversational book critiques the field's dominant theories by analyzing gendered patterns of perpetration and victimization and challenging traditional criminological perspectives on characteristics such as race and queerness. Designed as a rebuttal to conventional criminology textbooks, the book mirrors standard course content through an intersectional feminist lens, offering students a valuable opportunity to question the field's underpinnings and forge a new path to understanding the true meaning of justice. Organized in fourteen chapters, each chapter includes accessible learning aids for students: A review of how traditional criminology textbooks cover the topic. Critical perspectives on the topic. Critical thinking breaks. Intersectional Feminist Criminology is a timely intervention and companion to the curriculum that helps to imagine a new world and ultimately lays out a clear abolitionist vision as an alternative to the American criminal legal system. © 2025 by Venezia Michalsen. All rights reserved.

This innovative book examines the controversial relationship between motivation and rewards from multiple theoretical and practical perspectives. It analyzes cutting-edge research on work motivation and reward management's economic and psychological roots and identifies future directions for advancement in the field. © Zheni Wang 2025.

Partonic collectivity is one of the necessary signatures for the formation of quark-gluon plasma in high-energy nuclear collisions. Number of constituent quarks (NCQ) scaling has been observed for hadron elliptic flow v_{2} in top energy nuclear collisions at the Relativistic Heavy Ion Collider and the LHC, and this has been theoretically suggested as strong evidence for partonic collectivity. In this Letter, a systematic analysis of v_{2} of π^{±}, K^{±}, K_{S}^{0}, p, and Λ in Au+Au collisions at sqrt[s_{NN}]=3.2, 3.5, 3.9, and 4.5 GeV, with the STAR experiment at the Relativistic Heavy Ion Collider, is presented. NCQ scaling is markedly violated at 3.2 GeV, consistent with a hadronic-interaction dominated equation of state. However, as the collision energy increases, a gradual evolution to NCQ scaling is observed. This beam-energy dependence of v_{2} for all hadrons studied provides evidence for the onset of dominant partonic interactions by sqrt[s_{NN}]=4.5  GeV.

The plant epidermis is a single layer of cells covering all plant organs. How pathogens overcome this barrier and enter plants is an important aspect of plant-pathogen interactions. For bacterial plant pathogens, known entry points include natural openings, such as stomata, hydathodes, and mechanical injuries caused by insect feeding, wind damage, or hailstorms. Here, we report that the fire blight pathogen Erwinia amylovora enters apple leaves through naturally occurring wounds caused by the abscission of trichomes during the course of leaf development. Through macroscopic and microscopic observations, we depicted a clear invasion path for E. amylovora cells, from epiphytic growth on glandular trichomes (GT) and non-glandular trichomes (NT) to entry through wounds caused by abscised trichomes, into the epithem, and subsequent spread through xylem. We further observed that GT and NT undergo an abscission process, and that the amount of naturally occurring wounds during abscission is associated with the increase in E. amylovora population. Key genes important for the colonization of GT and NT were identified. The contribution of the type III secretion system and amylovoran biosynthesis during GT colonization was validated. Our findings propose a novel host entry mechanism of plant pathogenic bacteria through naturally occurring wounds during the abscission of plant surface structures.

A proper Skolem labelling of a graph G is a function assigning a positive integer to each vertex of G such that any two vertices assigned the same integer are that distance apart in the graph. The Skolem number of a graph is smallest number n such that there exists a proper Skolem labelling only using the positive integers less than or equal to n. In this paper, we will begin by proving the Skolem number for another family of subgraphs of the hexagonal lattice and then prove the Skolem number for two families of subgraphs of the Kagome Lattice. © 2025 Georgia Southern University. All rights reserved.

The search for selective anticholinergic agents stems from varying cholinesterase levels as Alzheimer’s Disease progresses from the mid-to-late stage and from butyrylcholinesterase’s (BChE) role in β-amyloid plaque formation. While structure-based and pharmacophore-based virtual screening could search from large libraries in a short time, these methods do not consider dynamic features that result from a ligand’s inhibition of the enzyme and consequently may under- or overexaggerate enzyme selectivity of a given ligand. In this computational study, we probed the selectivity of representative secondary metabolite compounds against acetylcholinesterase and BChE through molecular dynamics simulations. The results were evaluated by analysis of the root mean squared deviation of ligand heavy atoms, the radius of gyration of each inhibited and uninhibited enzyme, root mean squared fluctuation of residues, intermolecular interaction energy, and linear interaction energy approximation of the Gibbs free energy of binding. These considerations further reveal the induced-fit characteristics contributing to ChE selectivity that are predominantly due to the greater flexibility of BChE’s active site gorge.

This article explains how to use and apply the SHAPE America position statement “Physical Activity Should Not Be Used as Punishment and/or Behavior Management” in one’s own teaching and as an advocacy tool. © 2025 SHAPE America.

To increase patrons’ ability to find resources, it is imperative to investigate barriers and biases in thedescriptive catalog data for inclusive collection management and development standards. This studyused a specially designed descriptive approach to gather quantitative data from 101 public librariansin Connecticut via a Qualtrics survey to identify the key variables that influence the successfulenhancement of online public access catalog (OPAC) metadata after a diversity audit of the librarymaterials. The results revealed factors that promote or impede the integration of inclusive catalogingthat reflects the diversity of the community: (1) appreciating the benefits of audit methods that arefocused on bibliographic records, (2) recognizing the need for buy-in and participation from theentire organization, and (3) stressing the useful integration of institutional and community feedbackto improve the collection’s accessibility and representation. The findings provide practical adviceto public libraries that want to satisfy the diverse demands of their user base by integrating criticalcataloging frameworks into their diversity and inclusion objectives.

Entering a counselor education program is just the first step in becoming a Professional Counselor, which includes developing a solid Professional Counselor identity and a plan for a fulfilling career. In this chapter, the authors provide a step-by-step plan for understanding key elements of becoming a Professional Counselor, beginning to work as a Professional Counselor, and contributing to the counseling profession. These activities include professional involvement, service, and scholarship as well as other meaningful pursuits for building one's successful career. The authors present a professional involvement pyramid to illustrate how Counselors can engage in professional identity development from graduate school throughout their careers. © Oxford University Press 2025. All rights reserved.