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Purpose: Extant literature suggests that the difficulty associated with the interpretation of macroeconomic news announcements by the market in general in different economic environments, might be the reason why most studies do not find any significant relationship between real-sector macroeconomic variables and financial asset returns. This paper aims to use a different approach to measure macroeconomic news. The objective is to examine if a different measure of a macroeconomic news variable, constructed from media coverage of the same, significantly affects hedge fund returns. Design/methodology/approach: The authors use a news index for unemployment, which is a real-sector variable, constructed from newspaper coverage of unemployment announcements and examine its impact on hedge fund returns. Findings: Contrary to the other studies that examine the impact of macroeconomic news on hedge fund returns, the authors find that media coverage of unemployment news announcements significantly affects hedge fund returns. Practical implications: Overall, this paper demonstrates that the manner in which the market interprets macroeconomic news announcements in different economic environments is probably a more relevant factor for hedge funds and is more likely to impact hedge fund returns. In conjunction with variables – constructed from media coverage of unemployment news announcements – that factor in the manner of interpretation, it is found that surprises also matter for hedge fund returns. This is an important consideration for hedge fund managers as well. Originality/value: To the best of the authors’ knowledge, this is the first study that examines the impact of media coverage of macroeconomic news announcements on hedge fund returns and finds significantly different results with real-sector macro variables. © 2019, Emerald Publishing Limited.

Anti-drug vaccines have potential as new interventions against substance use disorder (SUD). However, given the challenges seen with inter-individual variability in SUD vaccine trials to date, new interventions should ensure a robust immune response and safety profile among a diverse population. This requires accounting for sex and heritable genetic differences in response to both abused substances as well as the vaccination itself. To test response variability to our heroin-tetanus toxoid (Her-TT) immunoconjugate vaccine, we vaccinated male and female mice from several mouse strains including Swiss Webster (SW), BALB/c, and Jackson diversity mice (J:DO). Previous studies with vaccinated male SW mice demonstrated a rare hypersensitivity resulting in mice rapidly expiring with exposure to a low dose of heroin. Our results indicate that this response is limited to only male SW mice, and not to any other strain or female SW mice. Our data suggest that this hypersensitivity is not the result of an overactive cytokine or IgE response. Vaccination was similarly effective among the sexes for each strain and against repeated heroin challenge. Inbred BALB/c and J:DO mice were found to have the best vaccine response against heroin in antinociception behavioral assay. These results highlight the importance of incorporating both male and female subjects, along with different strains to mimic diverse human populations, as new SUD vaccines are being tested.

We report the first measurements of a complete second-order cumulant matrix of net-charge, net-proton, and net-kaon multiplicity distributions for the first phase of the beam energy scan program at the Relativistic Heavy Ion Collider. This includes the centrality and, for the first time, the pseudorapidity window dependence of both diagonal and off-diagonal cumulants in Au+Au collisions at √sNN= 7.7–200 GeV. Within the available acceptance of |η|<0.5, the cumulants grow linearly with the pseudorapidity window. Relative to the corresponding measurements in peripheral collisions, the ratio of off-diagonal over diagonal cumulants in central collisions indicates an excess correlation between net-charge and net-kaon, as well as between net-charge and net-proton. The strength of such excess correlation increases with the collision energy. The correlation between net-proton and net-kaon multiplicity distributions is observed to be negative at √sNN= 200 GeV and change to positive at the lowest collision energy. Model calculations based on nonthermal (UrQMD) and thermal (HRG) production of hadrons cannot explain the data. These measurements will help map the quantum chromodynamics phase diagram, constrain hadron resonance gas model calculations and provide new insights on the energy dependence of baryon-strangeness correlations.

The results of speckle interferometric observations at the 4.1 m Southern Astrophysical Research Telescope (SOAR) in 2018 are given, totaling 3097 measurements of 2427 resolved pairs with separations from 11 mas to 5.″9 (median 0.″15, magnitude difference up to 7 mag) and nonresolutions of 624 targets. This work continues our long-term speckle program. Its main goal is to monitor orbital motion of close binaries, including members of high-order hierarchies and Hipparcos pairs in the solar neighborhood. Also, pre-main-sequence stars in the Orion OB1 association were surveyed, resolving 26 out of 118 targets. In addition, we report the discovery of 35 new companions among field visual multiples (some of which are likely optical) and first-time resolutions of another 31 pairs. By combining the measurements given here with the published ones, we computed 76 orbits for the first time and updated orbital elements of 34 visual binaries. Their periods range from 0.65 to 1100 yr, and their quality varies from first tentative solutions of grade 5 to accurate elements of grades 1 and 2. Finally, a list of 53 spurious pairs discovered by various techniques and unresolved at SOAR is given. © 2019. The American Astronomical Society. All rights reserved..

There is currently no generally accepted definition for the “blue economy,” despite the term becoming common parlance over the past decade. The concept and practice have spawned a rich, and diverse, body of scholarly activity. Yet despite this emerging body of literature, there is ambiguity around what the blue economy is, what it encapsulates, and its practices. Thus far, the existing literature has failed to theorise key geographical concepts such as space, place, scale, and power relations, all of which have the potential to lead to uneven development processes and regional differentiation. Previous research has sought to clarify the ontological separation of land and sea or has conceptualised the blue economy as a complex governmental project that opens up new governable spaces and rationalises particular ways of managing marine and coastal regions. More recently, geographers have called for a critical—and practical—engagement with the blue economy. This paper critically examines the existing literature of the geographies of the blue economy through a structured meta-analysis of published work, specifically its conceptualisations and applications to debates in the field. Results offer the potential to ground a bottom-up definition of the blue economy. In so doing, this paper provides a clearly identifiable rubric of the key geographical concepts that are often overlooked by researchers, policymakers, and practitioners when promoting economic development and technological innovation in coastal and marine environments. © 2019 The Author(s) Geography Compass © 2019 John Wiley & Sons Ltd

Civil and religious authorities in eighteenth-century America grew increasingly concerned over the freedom with which young people chose their marriage partners. Correlating racial, religious and cultural similarity in marriage to a stable society, these authorities attempted to limit marriage and sexual choices by requiring parental authority for marriage, distributing permits to a select few to perform marriages, and criminalizing racial miscegenation. Eighteenth-century Pennsylvania German authorities supported this attitude because they associated ethnic and religious out-marriage with the weakening of the body and the destruction of society. My study uses the marriage and birth records of eighteenth-century Pennsylvania Germans to examine their marriage and sexual relationships. I discovered that Pennsylvania Germans overwhelmingly chose to marry other German-speakers, out of proportion with their population. By examining the then available works on marriage and procreation, I discovered that Pennsylvania Germans read works that emphasized the necessity and importance of intra-ethnic and religious sex and marriage for the health of their children. Pennsylvania Germans chose their marriage partners in alignment with their community’s attitudes towards those of other ethnicities and religions. A small data set further suggests that relationships with non-Germans occurred but rarely became formalized. This complicates what we know about the sexual and emotional revolutions in the seventeenth and eighteenth centuries; far from a linear progression of attitudes towards sex, marriage, and others, eighteenth-century Pennsylvania Germans expressed multiple, contextually-driven perspectives, and in the process they created and maintained strong ethnic communities. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Public libraries have been significantly affected by the opioid crisis. The fact that patrons can enter libraries freely and do not need a reason to be there has resulted in overdoses occurring in many such buildings throughout the country. In response to this, library directors have developed plans of action that, in some cases, include training librarians to administer the opioid overdose reversal drug Naloxone. This present article – the first in a two-part study – is based on interviews with representatives from libraries that have been significantly affected by the opioid crisis. After describing these community circumstances, the authors analyze various ways that each library has prepared to respond to overdoses and other emergency situations.

Numerous articles from major national newspapers have covered the fact that as the opioid crisis has become a pervasive problem in the United States, overdoses in public libraries have become a somewhat common occurrence. Many of these discussions center on librarians being trained to use the overdose reversal drug Naloxone, and that was the primary focus of the first part of this two-part study. However, this second article discusses what libraries are doing to mitigate the impacts of the crisis and help persons from vulnerable populations before matters escalate to become emergency situations. The authors document how libraries are attempting to educate their communities about the opioid crisis, ways they have partnered with community organizations to help opioid dependent persons, and how they have addressed various facilities and security concerns for their buildings.

College may be considered a gateway to success, yet access to college is limited for young adults with autism. Given the research recommendations to elicit student experiences and to communicate among universities to improve college access, success, and equity, the present study examined the questions: What factors are perceived as pathways to success or barriers to success by college students on the autism spectrum? What university provided accommodations and/or support services do they prefer? Participants from four universities completed surveys and semi-structured interviews. Findings from the multi-university study suggest the need to provide transition planning and systematic non-academic social and emotional supports from the start of the college experience as well as specific training for faculty, staff, and peers.

Evolutionary biologists have long trained their sights on adaptation, focusing on the power of natural selection to produce relative fitness advantages while often ignoring changes in absolute fitness. Ecologists generally have taken a different tack, focusing on changes in abundance and ranges that reflect absolute fitness while often ignoring relative fitness. Uniting these perspectives, we articulate various causes of relative and absolute maladaptation and review numerous examples of their occurrence. This review indicates that maladaptation is reasonably common from both perspectives, yet often in contrasting ways. That is, maladaptation can appear strong from a relative fitness perspective, yet populations can be growing in abundance. Conversely, resident individuals can appear locally adapted (relative to nonresident individuals) yet be declining in abundance. Understanding and interpreting these disconnects between relative and absolute maladaptation, as well as the cases of agreement, is increasingly critical in the face of accelerating human-mediated environmental change. We therefore present a framework for studying maladaptation, focusing in particular on the relationship between absolute and relative fitness, thereby drawing together evolutionary and ecological perspectives. The unification of these ecological and evolutionary perspectives has the potential to bring together previously disjunct research areas while addressing key conceptual issues and specific practical problems. © 2019 by The University of Chicago. All rights reserved.

While extensive research has focused on how social interactions evolve, the fitness consequences of the neuroendocrine mechanisms underlying these interactions have rarely been documented, especially in the wild. Here, we measure how the neuroendocrine mechanisms underlying male behaviour affect mating success and sperm competition in the ocellated wrasse (Symphodus ocellatus). In this species, males exhibit three alternative reproductive types. “Nesting males” provide parental care, defend territories and form cooperative associations with unrelated “satellites,” who cheat by sneaking fertilizations but help by reducing sperm competition from “sneakers” who do not cooperate or provide care. To measure the fitness consequences of the mechanisms underlying these social interactions, we used “phenotypic engineering” that involved administering an androgen receptor antagonist (flutamide) to wild, free-living fish. Nesting males treated with flutamide shifted their aggression from sneakers to satellite males and experienced decreased submissiveness by sneaker males (which correlated with decreased nesting male mating success). The preoptic area (POA), a region controlling male reproductive behaviours, exhibited dramatic down-regulation of androgen receptor (AR) and vasotocin 1a receptor (V1aR) mRNA following experimental manipulation of androgen signalling. We did not find a direct effect of the manipulation on male mating success, paternity or larval production. However, variation in neuroendocrine mechanisms generated by the experimental manipulation was significantly correlated with changes in behaviour and mating success: V1aR expression was negatively correlated with satellite-directed aggression, and expression of its ligand arginine vasotocin (AVT) was positively correlated with courtship and mating success, thus revealing the potential for sexual selection on these mechanisms. © 2018 John Wiley & Sons Ltd

Instances of employees being `dooced' because of a social media post are becoming commonplace. Three research questions are presented to better understand workplace firings due to social media posts using justice theory and social convergence to fit within the nomological net. The first question examines employees' awareness of their employer's social media policy. The second question examines the role of offensiveness in the perceived fairness of the termination. The third question asks whether work-related posts (social convergence) and the presence of a social media policy (social media governance) influence the perception of termination fairness. Two data collection efforts are presented to test the research questions. The research findings extend the social media marketing governance literature by incorporating role theory and script theory. Managerial implications include the importance of developing and communicating to employees the organization's social media policies.

The role of the social worker in the achievement of human rights is to assist individuals in their struggle for dignity and their attainment of their full potential. Ethical social work ensures just laws and practices that allow all persons to live without discrimination. The purpose of this paper is to present the practice and policy implications of the last five years of court cases regarding transgender and gender expansive (TGE) children and school systems in the USA. This paper outlines the legal justifications for revisions to the current procedures and policies of interacting with TGE children, including use of restrooms consistent with gender identity (RCGI). These recommended guidelines are designed to prevent ongoing human rights violations and create pathways for TGE children to live their lives congruently with their gender identity. Basic human rights for the TGE individual include policy improvements involving restrooms, locker rooms, showers, overnight accommodation, affirmed name, and identification for the child welfare, mental health, educational, medical, juvenile justice, and law enforcement systems. © 2019, Springer Nature Switzerland AG.

Opioid abuse in the United States has been declared a national crisis and is exacerbated by an inexpensive, readily available, and illicit supply of synthetic opioids. Specifically, fentanyl and related analogues such as carfentanil pose a significant danger to opioid users due to their high potency and rapid acting depression of respiration. In recent years these synthetic opioids have become the number one cause of drug-related deaths. In our research efforts to combat the public health threat posed by synthetic opioids, we have developed monoclonal antibodies (mAbs) against the fentanyl class of drugs. The mAbs were generated in hybridomas derived from mice vaccinated with a fentanyl conjugate vaccine. Guided by a surface plasmon resonance (SPR) binding assay, we selected six hybridomas that produced mAbs with 10-11 M binding affinity for fentanyl, yet broad cross-reactivity with related fentanyl analogues. In mouse antinociception models, our lead mAb (6A4) could blunt the effects of both fentanyl and carfentanil in a dose-responsive manner. Additionally, mice pretreated with 6A4 displayed enhanced survival when subjected to fentanyl above LD50 doses. Pharmacokinetic analysis revealed that the antibody sequesters large amounts of these drugs in the blood, thus reducing drug biodistribution to the brain and other tissue. Lastly, the 6A4 mAb could effectively reverse fentanyl/carfentanil-induced antinociception comparable to the opioid antagonist naloxone, the standard of care drug for treating opioid overdose. While naloxone is known for its short half-life, we found the half-life of 6A4 to be approximately 6 days in mice, thus monoclonal antibodies could theoretically be useful in preventing renarcotization events in which opioid intoxication recurs following quick metabolism of naloxone. Our results as a whole demonstrate that monoclonal antibodies could be a desirable treatment modality for synthetic opioid overdose and possibly opioid use disorder.

Due to the difficulty of simultaneously assessing variation in individual physiology, behaviour and fitness, we often know little about the mechanistic basis of life-history trade-offs and fitness variation. It is similarly challenging to examine how physiological variation in one individual has cascading fitness consequences for others in the social environment. Using a wild-living fish (ocellated wrasse, Symphodus ocellatus), we manipulated a neuropeptide pathway associated with courtship, aggression and parental care in vertebrates (arginine vasotocin, AVT) and directly examined the behavioural and fitness consequences. Nesting males injected with the AVT antagonist increased their paternal care, resulting in increased hatching of offspring and increased reproductive success of all individuals that mated at his nest. By directly examining physiology, behaviour and reproductive success, we revealed how a small change in individual physiology has clear and direct fitness consequences for multiple individuals. © 2019 The Association for the Study of Animal Behaviour

One proposed factor contributing to the increased frequency of opioid overdose deaths is the emergence of novel synthetic opioids, including illicit fentanyl and fentanyl analogues. A treatment strategy currently under development to address the ongoing opioid crisis is immunopharmacotherapies or opioid-targeted vaccines. The present study determined the effectiveness and selectivity of a fentanyl-tetanus toxoid conjugate vaccine to alter the behavioral effects of fentanyl and a structurally dissimilar mu-opioid agonist oxycodone in male rhesus monkeys (n = 3-4). Fentanyl and oxycodone produced dose-dependent suppression of behavior in an assay of schedule-controlled responding and antinociception in an assay of thermal nociception (50 degrees C). Acute naltrexone (0.032 mg/kg) produced an approximate 10-fold potency shift for fentanyl to decrease operant responding. The fentanyl vaccine was administered at weeks 0, 2, 4, 9, 19, and 44 and fentanyl or oxycodone potencies in both behavioral assays were redetermined over the course of 49 weeks. The vaccine significantly and selectively shifted fentanyl potency at least 10-fold in both assays at several time points over the entire experimental period. Mid-point titer levels correlated with fentanyl antinociceptive potency shifts. Antibody affinity for fentanyl as measured by a competitive binding assay improved over time to approximately 3-4 nM. The fentanyl vaccine also increased fentanyl plasma levels approximately 6-fold consistent with the hypothesis that the vaccine sequesters fentanyl in the blood. Overall, these results support the continued development and evaluation of this fentanyl vaccine in humans to address the ongoing opioid crisis.

The current opioid crisis remains a significant public health issue and there is a critical need for biomedical research to develop effective and easily deployable candidate treatments. One emerging treatment strategy for opioid use disorder includes immunopharmacotherapies or opioid-targeted vaccines. The present study determined the effectiveness of a fentanyl-tetanus toxoid conjugate vaccine to alter fentanyl self-administration using a fentanyl-vs.-food choice procedure in male and female rats under three experimental conditions. For comparison, continuous 7-day naltrexone (0.01-0.1 mg/kg/h) and 7-day clonidine (3.2-10 mug/kg/h) treatment effects were also determined on fentanyl-vs.-food choice. Male and female rats responded for concurrently available 18% diluted Ensure R (liquid food) and fentanyl (0-10 mug/kg/infusion) infusions during daily sessions. Under baseline and saline treatment conditions, fentanyl maintained a dose-dependent increase in fentanyl-vs.-food choice. First, fentanyl vaccine administration significantly blunted fentanyl reinforcement and increased food reinforcement for 15 weeks in non-opioid dependent rats. Second, surmountability experiments by increasing the unit fentanyl dose available during the self-administration session 10-fold empirically determined that the fentanyl vaccine produced an approximate 22-fold potency shift in fentanyl-vs.-food choice that was as effective as the clinically approved treatment naltrexone. Clonidine treatment significantly increased fentanyl-vs.-food choice. Lastly, fentanyl vaccine administration prevented the expression of withdrawal-associated increases in fentanyl-vs.-food choice following introduction of extended 12 h fentanyl access sessions. Overall, these results support the potential and further consideration of immunopharmacotherapies as candidate treatments to address the current opioid crisis.