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The effectiveness of inclusion of students with disabilities in regular classrooms depends on many factors, among which, the teachers’ attitudes and competences play a key role. They are shaped in teaching practice and through socio-cultural experiences. To date, numerous studies have shown the importance of cross-cultural comparisons. The aim of the current study was to examine the relationship between self-efficacy and the attitudes towards including students with mild and moderate disabilities in mainstream education in teachers from Poland (n = 279) and India (n = 210). The differences found between the groups in the area of ⁣⁣sociodemographic variables and experiences in working with students with disabilities were the basis for including these variables in the analyses. Data were collected using the Attitudes Towards Teaching All Students Scale and Teacher Self-Efficacy Scale. The analysis allowed us to determine relationships between self-efficacy and attitudes towards integration of students with mild and moderate disabilities both in the group of Polish and Indian teachers. Generally, the obtained trends confirmed that higher teachers’ self-efficacy was associated with more favourable attitudes towards the inclusion of students with disabilities, but only in Indian group. The contribution of the variables of seniority, professional preparation and gender of the respondents was indicated. © 2025 Informa UK Limited, trading as Taylor & Francis Group.