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PurposeTo identify contributing factors to mental health symptoms and suicidality among sexual and gender minority (SGM) youth identified by quantitative research.MethodA scoping review was conducted, guided by the methodological framework of Arksey and O'Malley. Ten articles met inclusion criteria after a comprehensive search was performed across four databases.ResultsCommon factors identified as being associated with poor mental health outcomes and increased suicidality among SGM youth were environmental influences and minority stress. Factors were interrelated and often found to be associated with worsening anxiety, depression, and suicidal ideation.ConclusionFindings can be used to enhance the knowledge and training of nursing professionals to improve their understanding of the naturalistic course of poor mental health outcomes and suicidality in SGM youth. Future research should focus on screening tools and clinical interventions for SGM youth in need of mental health services. [Journal of Psychosocial Nursing and Mental Health Services, 63(7), 12–17.]