Full bibliography

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscale effects on many biological programs, including cellular proliferation, growth, and metabolism, as well as angiogenesis and hypoxia and innate and adaptive immunity. Here we highlight specific biological processes that could be exploited as targets for the prevention and therapy of cancer. Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted. We have also identified therapeutic agents as approaches, in particular natural products such as berberine, resveratrol, onionin A, epigallocatechin gallate, genistein, curcumin, naringenin, desoxyrhapontigenin, piperine, and zerumbone, that may warrant further investigation to target the tumor microenvironment for the treatment and/or prevention of cancer. Copyright © 2015 Elsevier Ltd. All rights reserved.

242 citations (Crossref) [2023-10-31] Place: England Casey, Stephanie C. Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA, United States. Amedei, Amedeo. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. Aquilano, Katia. Department of Biology, University of Rome "Tor Vergata", Rome, Italy. Azmi, Asfar S. Department of Oncology, Wayne State University School of Medicine, Detroit, MI, United States. Benencia, Fabian. Department of Biomedical Sciences, Ohio University, Athens, OH, United States. Bhakta, Dipita. School of Chemical and Biotechnology, SASTRA University, Thanjavur 613401, Tamil Nadu, India. Bilsland, Alan E. Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom. Boosani, Chandra S. Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE, United States. Chen, Sophie. Ovarian and Prostate Cancer Research Laboratory, Guildford, Surrey, United Kingdom. Ciriolo, Maria Rosa. Department of Biology, University of Rome "Tor Vergata", Rome, Italy. Crawford, Sarah. Department of Biology, Southern Connecticut State University, New Haven, CT, United States. Fujii, Hiromasa. Department of Orthopedic Surgery, Nara Medical University, Kashihara, Japan. Georgakilas, Alexandros G. Physics Department, School of Applied Mathematics and Physical Sciences, National Technical University of Athens, Athens, Greece. Guha, Gunjan. School of Chemical and Biotechnology, SASTRA University, Thanjavur 613401, Tamil Nadu, India. Halicka, Dorota. New York Medical College, Valhalla, NY, United States. Helferich, William G. University of Illinois at Urbana-Champaign, Champaign-Urbana, IL, United States. Heneberg, Petr. Charles University in Prague, Third Faculty of Medicine, Prague, Czech Republic. Honoki, Kanya. Department of Orthopedic Surgery, Nara Medical University, Kashihara, Japan. Keith, W Nicol. Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom. Kerkar, Sid P. Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Mohammed, Sulma I. Department of Comparative Pathobiology, Purdue University Center for Cancer Research, West Lafayette, IN, United States. Niccolai, Elena. University of Florence, Florence, Italy. Nowsheen, Somaira. Medical Scientist Training Program, Mayo Graduate School, Mayo Medical School, Mayo Clinic, Rochester, MN, United States. Vasantha Rupasinghe, H P. Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, Nova Scotia, Canada. Samadi, Abbas. Sanus Biosciences, San Diego, United States. Singh, Neetu. Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh, India. Talib, Wamidh H. Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman, Jordan. Venkateswaran, Vasundara. Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Whelan, Richard L. Mount Sinai Roosevelt Hospital, Icahn Mount Sinai School of Medicine, New York City, NY, United States. Yang, Xujuan. University of Illinois at Urbana-Champaign, Champaign-Urbana, IL, United States. Felsher, Dean W. Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: dfelsher@stanford.edu.