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Adolescents are sensitive to the anxiolytic effect of ethanol, and evidence suggests that they may be more sensitive to stress than adults. Relatively little is known, however, about age-related differences in stress modulation of ethanol drinking or stress modulation of ethanol-induced sedation and hypnosis. We observed that chronic restraint stress transiently exacerbated free-choice ethanol drinking in adolescent, but not in adult, rats. Restraint stress altered exploration patterns of a light-dark box apparatus in adolescents and adults. Stressed animals spent significantly more time in the white area of the maze and made significantly more transfers between compartments than their non-stressed peers. Behavioral response to acute stress, on the other hand, was modulated by prior restraint stress only in adults. Adolescents, unlike adults, exhibited ethanol-induced motor stimulation in an open field. Stress increased the duration of loss of the righting reflex after a high ethanol dose, yet this effect was similar at both ages. Ethanol-induced sleep time was much higher in adult than in adolescent rats, yet stress diminished ethanol-induced sleep time only in adults. The study indicates age-related differences that may increase the risk for initiation and escalation in alcohol drinking. Copyright © 2016 Elsevier Inc. All rights reserved.

27 citations (Crossref) [2023-10-31] Place: United States Fernandez, Macarena Soledad. Instituto de Investigacion Medica M. y M. Ferreyra (INIMEC - CONICET-Universidad Nacional de Cordoba), Cordoba, Argentina; Center for Development and Behavioral Neuroscience, Binghamton University, Binghamton, NY, USA. Fabio, Maria Carolina. Instituto de Investigacion Medica M. y M. Ferreyra (INIMEC - CONICET-Universidad Nacional de Cordoba), Cordoba, Argentina; Center for Development and Behavioral Neuroscience, Binghamton University, Binghamton, NY, USA. Miranda-Morales, Roberto Sebastian. Instituto de Investigacion Medica M. y M. Ferreyra (INIMEC - CONICET-Universidad Nacional de Cordoba), Cordoba, Argentina. Virgolini, Miriam B. Instituto de Farmacologia Experimental de Cordoba (IFEC-CONICET), Cordoba, Argentina; Departamento de Farmacologia, Facultad de Ciencias Quimicas, UNC, Cordoba, Argentina. De Giovanni, Laura N. Instituto de Farmacologia Experimental de Cordoba (IFEC-CONICET), Cordoba, Argentina; Departamento de Farmacologia, Facultad de Ciencias Quimicas, UNC, Cordoba, Argentina. Hansen, Cristian. Laboratorio de Analisis Clinicos Especializados (LACE), Cordoba, Argentina. Wille-Bille, Aranza. Instituto de Investigacion Medica M. y M. Ferreyra (INIMEC - CONICET-Universidad Nacional de Cordoba), Cordoba, Argentina. Nizhnikov, Michael E. Southern Connecticut State University, New Haven, CT, USA. Spear, Linda P. Center for Development and Behavioral Neuroscience, Binghamton University, Binghamton, NY, USA. Pautassi, Ricardo Marcos. Instituto de Investigacion Medica M. y M. Ferreyra (INIMEC - CONICET-Universidad Nacional de Cordoba), Cordoba, Argentina; Facultad de Psicologia, Universidad Nacional de Cordoba (UNC), Cordoba, Argentina. Electronic address: rpautassi@gmail.com.