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Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: Antinociceptive evaluation of fentanyl-contaminated heroin
Resource type
Authors/contributors
- Hwang, Candy S. (Author)
- Smith, Lauren C. (Author)
- Natori, Yoshihiro (Author)
- Ellis, Beverly (Author)
- Zhou, Bin (Author)
- Janda, Kim D. (Author)
Title
Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: Antinociceptive evaluation of fentanyl-contaminated heroin
Abstract
Fentanyl and its derivatives have become pervasive contaminants in the U.S. heroin supply. Previously, we reported a proof-of-concept vaccine designed to combat against heroin contaminated with fentanyl. Herein, we optimized the admixture vaccine and found that it surpassed the individual vaccines in every antinociceptive test, including a 10% fentanyl to heroin formulation. It is anticipated that other co-occurring drug abuse disorders may also be examined with admixture vaccines. © 2018 American Chemical Society.
Publication
ACS Omega
Date
2018-09-30
Volume
3
Issue
9
Pages
11537-11543
Journal Abbr
ACS Omega
Citation Key
hwangImprovedAdmixtureVaccine2018
Accessed
10/2/19, 2:52 PM
ISSN
2470-1343, 2470-1343
Short Title
Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates
Language
English
Library Catalog
DOI.org (Crossref)
Extra
31 citations (Crossref) [2023-10-31]
Citation
Hwang, C. S., Smith, L. C., Natori, Y., Ellis, B., Zhou, B., & Janda, K. D. (2018). Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: Antinociceptive evaluation of fentanyl-contaminated heroin. ACS Omega, 3(9), 11537–11543. https://doi.org/10.1021/acsomega.8b01478
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