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Diabetes mellitus is a chronic disease affecting over 38.4 million adults worldwide. Unfortunately, 8.7 million were undiagnosed. Early detection and diagnosis of diabetes can save millions of people’s lives. Significant benefits can be achieved if we have the means and tools for the early diagnosis and treatment of diabetes since it can reduce the ratio of cardiovascular disease and mortality rate. It is urgently necessary to explore computational methods and machine learning for possible assistance in the diagnosis of diabetes to support physician decisions. This research utilizes machine learning to diagnose diabetes based on several selected features collected from patients. This research provides a complete process for data handling and pre-processing, feature selection, model development, and evaluation. Among the models tested, our results reveal that Random Forest performs best in accuracy (i.e., 0.945%). This emphasizes Random Forest’s efficiency in precisely helping diagnose and reduce the risk of diabetes.

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