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The spread of COVID-19 has thrown the world into a panic. We are constantly learning more about the virus every day, from how it spreads to who is more susceptible to becoming infected by different variants. Those with underlying respiratory conditions and other immunocompromised individuals need to be extra cautious regarding the virus. Many researchers have created COVID-19 trackers to detect the spread of COVID-19 around the world and show hot spots where COVID-19 cases are more prevalent. Previous work lacks the consideration of comorbidity as a factor of death rate. This work aims to create an agent-based model to predict comorbidity death rate caused by a health condition in addition to COVID-19. The model is evaluated using the symmetric mean absolute percentage error metric and proved to be very efficient.

High-Throughput DNA and RNA sequencing are revolutionizing precision oncology, enabling personalized therapies such as cancer vaccines designed to target tumor-specific neoepitopes generated by somatic mutations expressed in cancer cells. Identification of these neoepitopes from next-generation sequencing data of clinical samples remains challenging and requires the use of complex bioinformatics pipelines. In this paper, we present GeNeo, a bioinformatics toolbox for genomics-guided neoepitope prediction. GeNeo includes a comprehensive set of tools for somatic variant calling and filtering, variant validation, and neoepitope prediction and filtering. For ease of use, GeNeo tools can be accessed via web-based interfaces deployed on a Galaxy portal publicly accessible at https://neo.engr.uconn.edu/. A virtual machine image for running GeNeo locally is also available to academic users upon request. © Copyright 2023, Mary Ann Liebert, Inc., publishers 2023.

Whalebacks, roche moutonnées, and S-forms carved on Ediacaran granitoids near Cerro de las Cuentas, Uruguay, along with overlying diamictites, siltstones, and sandstones displaying soft-sediment grooved and striated surfaces in the Pennsylvanian San Gregorio Formation, record the glacial to post-glacial transition in the linked Norte, southern Paraná and Chaco-Paraná basins of Uruguay, Brazil, and Argentina respectively. Early authors reported these features resulted from subglacial abrasion and deposition as lodgement tills and glaciotectonites. Our re-examination reveals a nuanced setting with changing ice thicknesses, subglacial kinematics, and ice proximal glaciomarine dynamics associated with advance and retreat of an ice stream, or multiple advances of the Uruguayan Ice lobe, during glaciation of the Late Paleozoic Ice Age (LPIA) in these basins. The preserved landforms indicate temperate glacial conditions. Whalebacks formed under 1.6 to 2.5 km-thick ice and likely formed when the lobe extended across the Uruguayan and Rio Grande do Sul shields into the adjacent Paraná Basin. Previously unidentified m-scale roches moutonnées cut into one whaleback developed under thinner ice where reduced basal pressure allowed for the opening of air and water-filled cavities, thus facilitating quarrying on the lee side of basement bumps. S-forms provide additional evidence for the occurrence of subglacial waters, indicating that the basal ice was at or above its pressure melting point. The lower meter of the overlying strata consists of interstratified trace fossil-bearing, laminated siltstones; thin-bedded diamictites; and current-rippled sandstones. Trace fossils belonging to the Mermia ichnofacies within the basal siltstones, as well as acritarchs in the overlying siltstones, suggest that these sediments were deposited in ice-proximal subaqueous settings with contributions from meltwater discharge. Graded siltstone laminae suggest settling from suspension likely from meltwater plumes, while thin-bedded diamictites were deposited either as debris flows or as two-component sedimentation with fines settling from suspension and coarser particles introduce as iceberg-rafted dropstones. Current-rippled sandstones indicate the occurrence of underflow currents. Soft-sediment troughs, grooves, and striations cutting these sediments display curved and sinuous paths with some features oriented perpendicular, and one oriented opposite to the overall trend. They contain marginal and terminal berms typical of iceberg scour marks suggesting transit across the area by icebergs calving from a tidewater ice front located to the SE.

Geography has engaged in insightful discussions on how to understand, analyze, criticize, and implement the blue economy. United Nations agencies, Small Island Developing States, and increased academic interest in oceans have played important roles in the global adoption of the blue economy idea, that is, the sustainable exploitation of marine and coastal resources. Geographical research on the blue economy has addressed key themes such as economic and political discourse, relational thinking and assemblage, sustainability and just transitions, and blue economy risks.

Importance: Play is an area of difficulty for autistic children, and occupational therapy practitioners need evidence to guide interventions to improve play for this population. Ayres Sensory Integration® (ASI) intervention has not yet been studied for its impact on play outcomes.Objective: To examine the impact of ASI intervention on play types in autistic children.Design: Nonconcurrent, multiple-baseline design across subjects.Setting: Outpatient occupational therapy clinic in New England.Participants: Three autistic children, ages 5, 6, and 6 yr.Intervention: Twenty-four ASI sessions.Outcomes and Measures: Frequency of play type was coded using partial interval coding. Progress monitoring used Goal Attainment Scaling.Results: All three participants demonstrated changes in the frequency of specific types of play, but changes varied among them.Conclusions and Relevance: Findings suggest that ASI intervention may alter a child’s patterns of play.What This Article Adds: This study is the first to examine the impact of ASI on play and the third that documents the feasibility of single-subject research for studying ASI. If confirmed in future studies, ASI could become an evidence-based intervention for improving play, an important outcome for autistic children and the profession of occupational therapy.Positionality Statement: This article uses the identity-first language autistic people. This nonableist language describes their strengths and abilities and is a conscious decision. This language is favored by autistic communities and self-advocates and has been adopted by health care professionals and researchers (Bottema-Beutel et al., 2021; Kenny et al., 2016).

This pilot study explored the use of standardized patients in the virtual classroom in efforts to increase family nurse practitioner preparedness to engage in telemedicine care delivery. Using a mixed-methods approach, we determined this innovation significantly increased students' confidence in their ability to perform a telemedicine visit while also improving their satisfaction with the virtual classroom.

Nearly eight million American youth between the ages of 3 - 17 live with a psychiatric or behavioral health disorder. Many in grades K-12 are being unfavorably impacted in the classroom because of socioeconomic and environmental factors that include poverty, addiction, incarceration, trauma, domesti...

Through the analysis of a hosted dinner, crane-meat, its preparation, and a lover's ultimatum the article shows that in Chichibio's novella (Decameron VI,4) there is more at play than just the lies, wit, and cunning that a Venetian cook relies on as survival mode. In fact, the roasted crane-leg stolen by the cook for his lover upends the established social and cultural order that Currado Gianfigliazzi exemplifies. Pruning away at established norms while depicting a servant who projects self-confidence, shrewdness, and the ability to adjust to contingencies, Boccaccio's tale demonstrates that Chichibio's (and his lover's) personal fulfillment rests neither on prides nor privileges, but on their ability to envision and seize what lies beyond the norms.

This article focuses on the complex interaction between trade and the environment. The first section reviews the debate among scholars on the environmental effects of trade. Next the article examines the role of the World Trade Organization and how its decisions have impacted the environment. This is followed by a discussion of climate change and its connection to trade. Finally, the article examines multilateral efforts to govern trade and control its environmental consequences as well as to encourage sustainable development. © 2022 Elsevier Inc. All rights reserved.

SHAPE America (2021) contends the use of physical activity used as punishment and/or behavior management as an inappropriate practice. The position statement acknowledges both the administration and withholding of physical activity as punishment, however, this paper focuses on the use of exercise as punishment (EAP) in physical education settings. While deemed inappropriate, the use of EAP is still happening today (Barney et al., 2016). The purpose of this viewpoint paper is to encourage appropriate pedagogies and practices while increasing awareness of national recommendations. Strategies for advocacy efforts are discussed.

This study presents an original model that features the emotion of fear of COVID-19 as a direct effect on vaccination intentions. A central research question addressed in the study is what roles do the emotion of fear of contracting COVID-19 and the threat posed by uptake of the COVID-19 vaccination play in levels of vaccination intention? The study used a structural equation model (SEM) and applied the SmartPLS 3.2.6 data analysis tool for model estimation and multivariate analysis variables. A key finding is that vaccination resistance is strongest when fear of COVID-19 is lower, and vaccination threat higher. Vaccination threat appraisal and vaccination intention were found to have a negative relationship. Response costs at higher levels lessen motivation for COVID-19 vaccination. Research implications include research-based targeting of differing segments by their primary fear, either fear of COVID-19 or of the preventative vaccine.

The use of Critical Race Theory, Photovoice, and Community-Based Participatory Research has helped uncover the root causes of issues such as systemic racism in the fields of public health and health promotion. Often, we see studies using traditional research methods to investigate potential causal factors of disparities in minoritized communities report only quantitative data. While these data are imperative for understanding the severity of disparities, quantitative-only approaches cannot address nor can they improve the critical root causes of these disparities. As a team of BIPOC graduate students in public health, we conducted a community-based participatory research project using Photovoice methodology to explore inequities in Black and Brown communities exacerbated during the COVID-19 pandemic. The participatory nature of this research revealed cumulative challenges across the social determinants of health in New Haven and Bridgeport, Connecticut. It allowed us to engage in local-level advocacy to promote health equity as our findings illuminated the need for community-led and community-engaged action. Health and racial inequities cannot be effectively addressed if public health research and programming do not collaborate with the community to build community capacity, empowerment, and trust. We describe our experiences doing community-based participatory research to investigate inequities and provide reflections on their value for public health students. As responses to health inequities and disparities become more politically polarized in the United States, it is critical for public health and health education students to use research methodologies that elevate communities that have been historically marginalized and neglected. Together, we can catalyze equitable change.

We introduce the notion of residual intersections of modules and prove their existence. We show that projective dimension one modules have Cohen-Macaulay residual intersections, namely they satisfy the relevant Artin-Nagata property. We then establish a formula for the core of orientable modules satisfying certain homological conditions, extending previous results of Corso, Polini, and Ulrich on the core of projective one modules. Finally, we provide examples of classes of modules that satisfy our assumptions.