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The search for selective anticholinergic agents stems from varying cholinesterase levels as Alzheimer’s Disease progresses from the mid to late stage. In this computational study, we probed the selectivity of FDA-approved and metabolite compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with molecular-docking-based virtual screening. The results were evaluated using locally developed codes for the statistical methods. The docking-predicted selectivity for AChE and BChE was predominantly the consequence of differences in the volume of the active site and the narrower entrance to the bottom of the active site gorge of AChE. © 2024 by the authors.
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This final commentary, in comic format, frames this special issue using Graphic Medicine methodologies to explore broader themes and meanings related to the scientific study of gender and health. Comics can be seen as a way to introduce complex human narratives and as an exploratory tool to ask broader social-contextual and ethical questions about health and medicine. This piece is also constructed through the lens of queer scholarship, which, together with the comics format, provides opportunities to build more embodied, complicated narratives about gender, sexuality and health. Most importantly, comics are used as a modality to tell compelling narratives about how individuals, rather than populations, may be impacted by biomedical conceptualizations of gender and health. The commentary includes a series of graphic narratives containing hypothetical stories and cases: stories of how individuals may be harmed within healthcare systems by rigid framings of gender, sex and sexuality, and stories about how gender socialization may impact health in subtle ways. These narratives furthermore examine the inextricable link between gender and power, illustrating how overt and covert manifestations of power may shape a person's health over the life course. Finally, the piece explores how expansive views of gender may contribute to positive health care experiences. The intention of this piece is to nudge scientific researchers and clinicians alike to approach the topic of gender, sexuality and health with nuance and curiosity. © 2023 The Author(s)
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The editors of Fragrant Frontier have produced an impressively researched book on the contemporary growers, in northern Vietnam and Southwest China, of three spices—star anise, black cardamom, and cinnamon, each of which has local, regional, and international economic importance—as well as the human links in the global commodity chain of these spices. This volume is much more coherent than many edited volumes, and readers should not skip any of it, as there are nice little surprises waiting here and there in the text.A good example is the “Preface and Acknowledgements” section, as this not only provides interesting information on how the volume came into being but also links to websites and scannable QR codes for “story maps” on the three spices and the places mentioned in the rest of the volume. This is a nice touch that gives this volume about the recent situation of farmers, local traders, marketplace workers, street vendors (of both the spices and foods prepared with them), wholesalers, exporters, and state officials a very contemporary feel. These story maps are only the first of an extensive number of relevant, well-done, and well-used illustrations including photographs, maps, and tables inserted throughout the following chapters.
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