Resonance raman of BCC and normal skin
Resource type
Authors/contributors
- Liu, Cheng-hui (Author)
- Sriramoju, Vidyasagar (Author)
- Boydston-White, Susie (Author)
- Wu, Binlin (Author)
- Zhang, Chunyuan (Author)
- Pei, Zhe (Author)
- Sordillo, Laura (Author)
- M.d, Hugh Beckman (Author)
- Alfano, Robert R. (Author)
Title
Resonance raman of BCC and normal skin
Abstract
The Resonance Raman (RR) spectra of basal cell carcinoma (BCC) and normal human skin tissues were analyzed using 532nm laser excitation. RR spectral differences in vibrational fingerprints revealed skin normal and cancerous states tissues. The standard diagnosis criterion for BCC tissues are created by native RR biomarkers and its changes at peak intensity. The diagnostic algorithms for the classification of BCC and normal were generated based on SVM classifier and PCA statistical method. These statistical methods were used to analyze the RR spectral data collected from skin tissues, yielding a diagnostic sensitivity of 98.7% and specificity of 79% compared with pathological reports.
Proceedings Title
Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis
Conference Name
Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis
Publisher
International Society for Optics and Photonics
Date
2017/02/17
Volume
10060
Pages
100601B
Citation Key
liuResonanceRamanBCC2017
Accessed
12/24/19, 3:55 PM
Language
English
Library Catalog
Extra
7 citations (Crossref) [2023-10-31]
Citation Key Alias: lens.org/015-837-955-575-755, pop00046
tex.type: [object Object]
Citation
Liu, C., Sriramoju, V., Boydston-White, S., Wu, B., Zhang, C., Pei, Z., Sordillo, L., M.d, H. B., & Alfano, R. R. (2017). Resonance raman of BCC and normal skin. Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 10060, 100601B. https://doi.org/10.1117/12.2254628
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