Undergraduate organic experiment: Tetrazole formation by microwave heated (3 + 2) cycloaddition in aqueous solution
Resource type
Authors/contributors
- DeFrancesco, Heather (Author)
- Dudley, Joshua (Author)
- Coca, Adiel (Author)
Title
Undergraduate organic experiment: Tetrazole formation by microwave heated (3 + 2) cycloaddition in aqueous solution
Abstract
An undergraduate experiment for the organic laboratory is described that utilizes microwave heating to prepare 5-substituted 1H-tetrazole derivatives through a (3 + 2) cycloaddition between aryl nitriles and sodium azide. The reaction mixture is analyzed by thin layer chromatography. The products are purified through an acid–base extraction and recrystallization. Characterization is accomplished using melting point, infrared, 1H NMR, and 13C NMR spectroscopy. Students are tasked with determining and confirming the structure of their product based on their assigned nitrile and characterization data.
Publication
Journal of Chemical Education
Date
March 13, 2018
Volume
95
Issue
3
Pages
433-437
Journal Abbr
J. Chem. Educ.
Citation Key
defrancescoUndergraduateOrganicExperiment2018
Accessed
10/2/19, 5:46 PM
ISSN
0021-9584
Short Title
Undergraduate organic experiment
Language
English
Library Catalog
ACS Publications
Extra
7 citations (Crossref) [2023-10-31]
Citation Key Alias: lens.org/045-369-826-868-934, pop00168
tex.type: [object Object]
Citation
DeFrancesco, H., Dudley, J., & Coca, A. (2018). Undergraduate organic experiment: Tetrazole formation by microwave heated (3 + 2) cycloaddition in aqueous solution. Journal of Chemical Education, 95(3), 433–437. https://doi.org/10.1021/acs.jchemed.7b00617
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